Results 41 to 50 of about 21,718 (291)

Retinal type VII collagen distribution.

, 2016
Immunohistochemical analysis at the vitreoretinal junction of a paraffin-embedded, serially sectioned (3–4 μm) human donor eye evaluated by light microscopy.
Roelofje J. Van der Worp (5666341), Leonoor I. Los (89478), Hendri H. Pas (89476), Bart Wullink (841699), Roel Kuijer (205680)   +4 more
core   +1 more source

A Gene Gun-mediated Nonviral RNA trans-splicing Strategy for Col7a1 Repair

Molecular Therapy: Nucleic Acids, 2016
RNA trans-splicing represents an auspicious option for the correction of genetic mutations at RNA level. Mutations within COL7A1 causing strong reduction or absence of type VII collagen are associated with the severe skin blistering disease dystrophic ...
Patricia Peking, Ulrich Koller, Stefan Hainzl, Sophie Kitzmueller, Thomas Kocher, Elisabeth Mayr, Alexander Nyström, Thomas Lener, Julia Reichelt, Johann W Bauer, Eva M Murauer   +10 more
doaj   +1 more source

The hinge region of type VII collagen is intrinsically disordered

Matrix Biology, 2014
Type VII collagen (Col7) is important for skin integrity. As a major component of the anchoring fibrils, Col7 is essential for linking different skin layers together. The central collagenous domain of Col7 contains several interruptions of the collagen triple helix.
Richer, Barbara Christine, Seeger, Karsten   +1 more
openaire   +2 more sources

Suppression of TGF_βand Angiogenesis by Type VII Collagen in Cutaneous SCC [PDF]

Journal of the National Cancer Institute, 2015
Individuals with severe generalized recessive dystrophic epidermolysis bullosa (RDEB), an inherited blistering disorder caused by mutations in the COL7A1 gene, develop unexplained aggressive squamous cell carcinomas (SCC). Here we report that loss of type VII collagen (Col7) in SCC results in increased TGFβ signaling and angiogenesis in vitro and in ...
Martins, VL, Caley, MP, Moore, K, Szentpetery, Z, Marsh, ST, Murrell, DF, Kim, MH, Avari, M, McGrath, JA, Cerio, R, Kivisaari, A, Kahari, VM, Hodivala-Dilke, K, Brennan, CH, Chen, M, Marshall, JF, O'Toole, EA   +16 more
openaire   +4 more sources

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Spontaneous internal carotid artery dissection in dystrophic bullous epidermolysis - association or determinant factor? [PDF]

Romanian Journal of Neurology, 2010
Pathogenesis of spontaneous carotid artery dissection (sCAD) is still a domain of research. Classical inherited connective tissue disease, primary or systemic arteriopathies and ultrastructural alterations of the arterial wall were reported in sCAD.
Alexandra Comanescu, Monica Sabau
doaj   +1 more source

IgE does not increase collagen type-IV deposition, but increases collagen type-VII diseases specifically.

, 2013
(A) IgE does not induce collagen type-IV deposition by ASMC. (B) IgE does not modify TGF-β1-induced collagen type-IV deposition. (C) IgE disease specifically increases the deposition of collagen type-VII by ASMC of asthma patients, (D) but has no ...
Michael Tamm (65010), Chong Teck S’ng (283750), Jun Zhong (236780), Stephanie Goulet (283752), Michael Roth (283746), Celine Zumkeller (283749)   +5 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Epidermolysis Bullosa (EB) Acquisita in an Adult Patient with Previously Unrecognized Mild Dystrophic EB and Biallelic COL7A1 Mutations

Acta Dermato-Venereologica, 2018
Circulating anti-type VII collagen autoantibodies are frequently detected in patients with recessive dystrophic epidermolysis bullosa (RDEB). However, evidence supporting their pathogenic role in inducing epidermolysis bullosa acquisita (EBA) has been ...
Liliana Guerra, Angelo Giuseppe Condorelli, Paola Fortugno, Valentina Calabresi, Cristina Pedicelli, Giovanni Di Zenzo, Daniele Castiglia   +6 more
doaj   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source