Results 31 to 40 of about 7,552,757 (294)

Pretibial dystrophic epidermolysis bullosa [PDF]

Anais Brasileiros de Dermatologia, 2017
Epidermolysis bullosa is a group of mechano-bullous genetic disorders caused by mutations in the genes encoding structural proteins of the skin. Dystrophic epidermolysis bullosa is caused by mutations in the COL7A1 gene encoding collagen VII, the main ...
Elisabeth de Albuquerque Cavalcanti Callegaro, Flavio Nappi, Rosana Lazzarini, Rute Facchini Lellis   +3 more
doaj   +1 more source

Plasmid-Encoded Outer Membrane Protein YadA Mediates Specific Binding of Enteropathogenic Yersiniae to Various Types of Collagen [PDF]

, 1992
The plasmid-encoded outer membrane protein YadA of enteropathogenic yersiniae is associated with pathogenicity. Recently, collagen binding of YadA-positive yersiniae was reported without detailed characterization (L. Emödy, J. Heesemann, H. Wolf-Watz, M.
Emmerich, F., Burkhardt, H., Schulze-Koops, Hendrik, Heesemann, Jürgen, Mark, K. von der   +4 more
core   +1 more source

Generation of rabbit polyclonal human and murine collagen VII monospecific antibodies: A useful tool for dystrophic epidermolysis bullosa therapy studies

Matrix Biology Plus, 2019
High conservation of extracellular matrix proteins often makes the generation of potent species-specific antibodies challenging. For collagen VII there is a particular preclinical interest in the ability to discriminate between human and murine collagen ...
Olivier Bornert, Thomas Kocher, Christine Gretzmeier, Bernadette Liemberger, Stefan Hainzl, Ulrich Koller, Alexander Nyström   +6 more
doaj   +1 more source

Structural and biophysical characterization of the type VII collagen vWFA2 subdomain leads to identification of two binding sites

FEBS Open Bio, 2020
Type VII collagen is an extracellular matrix protein, which is important for skin stability; however, detailed information at the molecular level is scarce.
Jan M. Gebauer, Florian Flachsenberg, Cordula Windler, Barbara Richer, Ulrich Baumann, Karsten Seeger   +5 more
doaj   +1 more source

The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling. [PDF]

PLoS ONE, 2013
BACKGROUND: In allergic asthma, IgE increases airway remodelling but the mechanism is incompletely understood. Airway remodelling consists of two independent events increased cell numbers and enhanced extracellular matrix deposition, and the mechanism by
Michael Roth, Jun Zhong, Celine Zumkeller, Chong Teck S'ng, Stephanie Goulet, Michael Tamm   +5 more
doaj   +1 more source

Collagen mRNA levels changes during colorectal cancer carcinogenesis

BMC Cancer, 2009
Background Invasive growth of epithelial cancers is a complex multi-step process which involves dissolution of the basement membrane. Type IV collagen is a major component in most basement membranes.
Tveit Kjell M, Lothe Inger MB, Anthonsen Dorit, Skovbjerg Hanne, Kure Elin H, Vogel Lotte K   +5 more
doaj   +1 more source

Preclinical model for phenotypic correction of dystrophic epidermolysis bullosa by in vivo CRISPR-Cas9 delivery using adenoviral vectors

Molecular Therapy: Methods & Clinical Development, 2022
Recessive dystrophic epidermolysis bullosa, a devastating skin fragility disease characterized by recurrent skin blistering, scarring, and a high risk of developing squamous cell carcinoma is caused by mutations in COL7A1, the gene encoding type VII ...
Marta García, Jose Bonafont, Jesús Martínez-Palacios, Rudan Xu, Giandomenico Turchiano, Stina Svensson, Adrian J. Thrasher, Fernando Larcher, Marcela Del Rio, Rubén Hernández-Alcoceba, Marina I. Garín, Ángeles Mencía, Rodolfo Murillas   +12 more
doaj   +1 more source

The regulation of type I collagen gene expression in stromal fibroblast by breast tumour cells [PDF]

, 2011
Includes abstract.Includes bibliographical references (leaves 110-135).Recent studies have revealed that interactions between tumour cells and the surrounding stroma play an important role in facilitating tumour growth and invasion.
Rose, Beverley Ann
core   +1 more source

Sources of Collagen for Biomaterials in Skin Wound Healing

Bioengineering, 2019
Collagen is the most frequently used protein in the fields of biomaterials and regenerative medicine. Within the skin, collagen type I and III are the most abundant, while collagen type VII is associated with pathologies of the dermal−epidermal ...
Evan Davison-Kotler, William S. Marshall, Elena García-Gareta   +2 more
doaj   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton. [PDF]

Adv Sci (Weinh)
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Bourne LE, Sharma A, Dillon S, Keen J, Jayash SN, Crump N, Evans LAE, Karmali M, Promruk W, Clarkin CE, Narisawa S, Stephen L, Foster BL, Millán JL, Farquharson C, Staines KA.   +15 more
europepmc   +2 more sources