Results 11 to 20 of about 21,718 (291)

Type VII collagen in Alport syndrome [PDF]

Nephrology Dialysis Transplantation, 2007
Absence or segmental distribution of the alpha5(IV) collagen chain along the epidermal basement membrane (EBM) is diagnostic of X-linked Alport syndrome (X-AS), but the typical morphologic alterations usually observed along the glomerular basement membrane (GBM) are lacking. However, several differences in protein composition exist between GBM and EBM,
GIANNAKAKIS, Konstantinos, L. Massella, D. Grassetti, F. Dotta, M. Perez, A. O. Muda   +5 more
core   +6 more sources

Restoring type VII collagen in skin

Med, 2022
New therapeutic hope is emerging for people with the rare inherited blistering skin disease recessive dystrophic epidermolysis bullosa (RDEB). Gurevich et al.1 have reported early-phase clinical trial data evaluating a topical herpes simplex virus 1 vector to restore missing type VII collagen in RDEB skin and heal wounds.
Lwin, Su M., McGrath, John A.
openaire   +4 more sources

The Epidermolysis Bullosa Acquisita Antigen (Type VII Collagen) is Present in Human Colon and Patients with Crohn's Disease have Autoantibodies to Type VII Collagen [PDF]

Journal of Investigative Dermatology, 2002
Epidermolysis bullosa acquisita is an autoimmune blistering disease of the skin characterized by IgG autoantibodies against type VII collagen. Systemic diseases are often associated with epidermolysis bullosa acquisita, Crohn's disease being the most frequent.
Chen, Mei, O'Toole, Edel A., Sanghavi, Jigisha, Woodley, David T., Mahmud, Nasir, Kelleher, Dermot, Weir, Donald, Fairley, Janet A.   +7 more
openaire   +4 more sources

Detection of Type VII collagen in odontogenic keratocyst: An immunohistochemical study [PDF]

Journal of Clinical and Experimental Dentistry, 2019
Separation of the epithelial lining from the underlying connective tissue wall has been a frequently observed and unique feature in odontogenic keratocysts (OKC), but not in other odontogenic cysts nor neoplasms. No study on OKC has been reported evaluating the role of type VII Collagen, the anchoring fibrils, which function in stabilising the ...
Cota, Jochima-Eudora, Spadigam, Anita, Dhupar, Anita   +2 more
openaire   +4 more sources

Anti-Type VII Collagen Antibodies Are Identified in a Subpopulation of Bullous Pemphigoid Patients With Relapse

Frontiers in Immunology, 2018
Bullous pemphigoid (BP) is an autoimmune bullous skin disease characterized by anti-BP180 and anti-BP230 autoantibodies (AAbs). Mucous membrane involvement is an uncommon clinical feature of BP which may evoke epidermolysis bullosa acquisita, another ...
Delphine Giusti, Delphine Giusti, Grégory Gatouillat, Grégory Gatouillat, Sébastien Le Jan, Julie Plée, Julie Plée, Philippe Bernard, Philippe Bernard, Frank Antonicelli, Frank Antonicelli, Bach-Nga Pham, Bach-Nga Pham   +12 more
doaj   +2 more sources

COL7A1 mutation G2037E causes epidermal retention of type VII collagen [PDF]

Journal of Human Genetics, 2006
COL7A1 glycine substitution (GS) mutations result in dominant and recessive dystrophic epidermolysis bullosa (DDEB and RDEB). Here, we report a DDEB family in which retention of type VII collagen by epidermal keratinocytes was observed for a female proband. Mutational analysis detected a GS mutation, G2037E, in the proband and her affected father.
Sawamura, Daisuke, Sato-Matsumura, Kazuko, Shibata, Satoko, Tashiro, Akari, Furue, Masutaka, Goto, Maki, Sakai, Kaori, Akiyama, Masashi, Nakamura, Hideki, Shimizu, Hiroshi   +9 more
openaire   +5 more sources

Childhood epidermolysis bullosa acquisita: Confirmation of diagnosis by skin deficient in Type VII Collagen, enzyme-linked immunosorbent assay, and immunoblotting

Indian Journal of Dermatology, 2016
Epidermolysis bullosa acquisita (EBA) is an acquired subepidermal bullous disorder characterized by autoantibodies against Type VII collagen. It usually affects adults; childhood EBA is rare. We describe a 10-year-old girl presenting with recurrent tense
Nupur Goyal, Raghavendra Rao, C Balachandran, Sathish Pai, Balbir S Bhogal, Enno Schmidt, Detlef Zillikens   +6 more
doaj   +2 more sources

Type VII Collagen, Anchoring Fibrils, and Epidermolysis Bullosa

Journal of Investigative Dermatology, 1993
The anchoring fibrils at the dermal-epidermal junction have been well characterized as ultrastructural entities. From their appearance, it was proposed that they fortified the attachment of the epidermis to the dermis. This hypothesized function was strengthened by observations indicating that the anchoring fibrils were abnormal, diminished, or absent ...
Burgeson, Robert E
openaire   +3 more sources

Immunohistochemical expression of collagen type VII antibody in the human fetal temporomandibular joint discs [PDF]

Einstein (São Paulo), 2007
Objective: To study the articular disc morphology and to analyze theimmunohistochemical expression of the type VII collagen marker inhuman fetal temporomandibular joint discs at different gestational ages.Methods: Twenty human fetal temporomandibular ...
Luís Otávio Carvalho de Morais, Fábio Redivo Lodi, Sergio Ricardo Marques, Celina Tizuko Fijiyama Oshima, João Antão Fernandes Júnior, Ricardo Luiz Smith, Luís Garcia Alonso   +6 more
doaj   +1 more source

Type VII collagen in the intraocular environment [PDF]

, 2019
This thesis describes the characteristics of type VII collagen (Col VII) in the intraocular environment, by means of immunohistochemical, -fluorescence and - immunoelectron microscopy analysis. Col VII is an anchoring protein that secures the epidermal basement membrane to the underlying stroma, by forming looped anchoring fibrils.
Wullink, Bart
core   +4 more sources