Results 21 to 30 of about 21,718 (291)

Functional Correction of Type VII Collagen Expression in Dystrophic Epidermolysis Bullosa [PDF]

Journal of Investigative Dermatology, 2011
Functional defects in type VII collagen, caused by premature termination codons on both alleles of the COL7A1 gene, are responsible for the severe autosomal recessive types of the skin blistering disease, recessive dystrophic epidermolysis bullosa (RDEB).
Murauer, Eva M., Gache, Yannick, Gratz, Iris K., Klausegger, Alfred, Muss, Wolfgang, Gruber, Christina, Meneguzzi, Guerrino, Hintner, Helmut, Bauer, Johann W.   +8 more
openaire   +3 more sources

Immunohistochemical localization of collagen types I and VI in human skin wounds [PDF]

, 1996
A total of 74 human skin wounds were investigated and collagen types I and VI were localized in the wound area by immunohistochemistry. Collagen type I appeared in the form of ramifying string-like structures after approximately 5–6 days, but positive ...
Penning, R., Eisenmenger, Wolfgang, Nerlich, A., Tübel, J., Wilske, J., Betz, P.   +5 more
core   +1 more source

The time-dependent rearrangement of the epithelial basement membrane in human skin wounds [PDF]

, 1992
In 62 human skin wounds (surgical wounds, stab wounds and lacerations after surgical treatment) we analyzed the immunohistochemical localization of collagen IV in the epithelial basement membrane.
Penning, R., Eisenmenger, Wolfgang, Nerlich, A., Tübel, J., Wilske, J., Betz, P., Wiest, I.   +6 more
core   +1 more source

The immunohistochemical analysis of fibronectin, collagen type III, laminin, and cytokeratin 5 in putrified skin [PDF]

, 1993
Fibronectin, collagen type III, laminin, and cytokeratin 5 were visualized in normal skin and in skin showing early or advanced signs of autolytic decomposition to prove whether the immunohistochemical analysis of these antigens can provide useful ...
Penning, R., Eisenmenger, Wolfgang, J. Tübel, Nerlich, A., A. Nerlich, W. Eisenmenger, Tübel, J., Wilske, J., J. Wilske, Betz, P., R. Penning, P. Betz   +11 more
core   +1 more source

Antisense Oligonucleotide-mediated Exon Skipping as a Systemic Therapeutic Approach for Recessive Dystrophic Epidermolysis Bullosa

Molecular Therapy: Nucleic Acids, 2016
The “generalized severe” form of recessive dystrophic epidermolysis bullosa (RDEB-gen sev) is caused by bi-allelic null mutations in COL7A1, encoding type VII collagen. The absence of type VII collagen leads to blistering of the skin and mucous membranes
Jeroen Bremer, Olivier Bornert, Alexander Nyström, Antoni Gostynski, Marcel F Jonkman, Annemieke Aartsma-Rus, Peter C van den Akker, Anna MG Pasmooij   +7 more
doaj   +1 more source

A Case of Systemic Lupus Erythematosus with Cutaneous Leukocytoclastic Vasculitis Mimicking Bullous SLE

Case Reports in Dermatology, 2021
Rarely, patients with systemic lupus erythematosus (SLE) develop bullous eruptions, a disease called bullous SLE in a narrow sense that has autoantibodies against type VII collagen.
Fumi Miyagawa, Kohei Ogawa, Takashi Hashimoto, Hideo Asada   +3 more
doaj   +1 more source

Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa.

PLoS ONE, 2015
Recessive dystrophic epidermolysis bullosa (RDEB) is caused by mutations in COL7A1 resulting in reduced or absent type VII collagen, aberrant anchoring fibril formation and subsequent dermal-epidermal fragility.
Stephen A Watt, Jasbani H S Dayal, Sheila Wright, Megan Riddle, Celine Pourreyron, James R McMillan, Roy M Kimble, Marco Prisco, Ulrike Gartner, Emma Warbrick, W H Irwin McLean, Irene M Leigh, John A McGrath, Julio C Salas-Alanis, Jakub Tolar, Andrew P South   +15 more
doaj   +1 more source

Pretibial dystrophic epidermolysis bullosa [PDF]

Anais Brasileiros de Dermatologia, 2017
Epidermolysis bullosa is a group of mechano-bullous genetic disorders caused by mutations in the genes encoding structural proteins of the skin. Dystrophic epidermolysis bullosa is caused by mutations in the COL7A1 gene encoding collagen VII, the main ...
Elisabeth de Albuquerque Cavalcanti Callegaro, Flavio Nappi, Rosana Lazzarini, Rute Facchini Lellis   +3 more
doaj   +1 more source

Generation of rabbit polyclonal human and murine collagen VII monospecific antibodies: A useful tool for dystrophic epidermolysis bullosa therapy studies

Matrix Biology Plus, 2019
High conservation of extracellular matrix proteins often makes the generation of potent species-specific antibodies challenging. For collagen VII there is a particular preclinical interest in the ability to discriminate between human and murine collagen ...
Olivier Bornert, Thomas Kocher, Christine Gretzmeier, Bernadette Liemberger, Stefan Hainzl, Ulrich Koller, Alexander Nyström   +6 more
doaj   +1 more source

Structural and biophysical characterization of the type VII collagen vWFA2 subdomain leads to identification of two binding sites

FEBS Open Bio, 2020
Type VII collagen is an extracellular matrix protein, which is important for skin stability; however, detailed information at the molecular level is scarce.
Jan M. Gebauer, Florian Flachsenberg, Cordula Windler, Barbara Richer, Ulrich Baumann, Karsten Seeger   +5 more
doaj   +1 more source