Results 21 to 30 of about 2,370 (176)

A novel Vi-diphtheria toxoid typhoid conjugate vaccine is safe and can induce immunogenicity in healthy Indonesian children 2–11 years: a phase II preliminary report

BMC Pediatrics, 2020
Background Typhoid fever caused by Salmonella enteric serovar Typhi (S. Typhi) is a common cause of morbidity in the world. In 2017, 14.3 million cases of Typhoid and paratyphoid fever occurred globally.
Bernie Endyarni Medise, Soedjatmiko Soedjatmiko, Hartono Gunardi, Rini Sekartini, Hindra Irawan Satari, Sri Rezeki Hadinegoro, Angga Wirahmadi, Mita Puspita, Rini Mulia Sari, Jae Seung Yang, Arijit Sil, Sushant Sahastrabuddhe, Novilia Sjafri Bachtiar   +12 more
doaj   +1 more source

Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal Salmonella Serovars

Frontiers in Immunology, 2020
Salmonella enterica infections remain a challenging health issue, causing significant morbidity and mortality worldwide. Current vaccines against typhoid fever display moderate efficacy whilst no licensed vaccines are available for paratyphoid fever or ...
Nuriban Valero-Pacheco, Nuriban Valero-Pacheco, Nuriban Valero-Pacheco, Joshua Blight, Gustavo Aldapa-Vega, Gustavo Aldapa-Vega, Phillip Kemlo, Marisol Pérez-Toledo, Marisol Pérez-Toledo, Isabel Wong-Baeza, Ayako Kurioka, Christian Perez-Shibayama, Cristina Gil-Cruz, Luvia E. Sánchez-Torres, Rodolfo Pastelin-Palacios, Armando Isibasi, Arturo Reyes-Sandoval, Paul Klenerman, Constantino López-Macías, Constantino López-Macías, Constantino López-Macías   +20 more
doaj   +1 more source

The Burden of Typhoid and Paratyphoid in India: Systematic Review and Meta-analysis.

PLoS Neglected Tropical Diseases, 2016
BackgroundTyphoid is an important public health challenge for India, especially with the spread of antimicrobial resistance. The decision about whether to introduce a public vaccination programme needs to be based on an understanding of disease burden ...
Jacob John, Carola J C Van Aart, Nicholas C Grassly   +2 more
doaj   +1 more source

Review of current typhoid fever vaccines, cross-protection against paratyphoid fever, and the European guidelines

Expert Review of Vaccines, 2017
Introduction: Typhoid and paratyphoid fever remain a global health problem, which – in non-endemic countries – are mainly seen in travelers, particularly in VFRs (visiting friends and relatives), with occasional local outbreaks occurring.
Jane N Zuckerman, Christoph Hatz, Anu Kantele   +2 more
doaj   +1 more source

Complex Adaptive Immunity to enteric fevers in humans: Lessons learned and the path forward

Frontiers in Immunology, 2014
Salmonella enterica serovar Typhi (S. Typhi), the causative agent of typhoid fever, and S. Paratyphi A and B, causative agents of paratyphoid fever, are major public health threats throughout the world.
Marcelo B. Sztein, Rosangela eSalerno-Goncalves, Monica A Mcarthur   +2 more
doaj   +1 more source

Characterization and protective efficacy of a sptP mutant of Salmonella Paratyphi A

Immunity, Inflammation and Disease, Volume 8, Issue 4, Page 774-781, December 2020., 2020
Salmonella Paratyphi A lacking sptP is attenuated, immunogenic, and protective in mice. The sptP mutant SPA017ΔsptP has the potential of being a live‐attenuated vaccine candidate. Abstract Background Salmonella Paratyphi A causes paratyphoid A, a severe systemic disease of people and remains a major public health problem in many parts of the world.
Pengtao Pan, Fanyu Zou, Chuanshan He, Qunli He, Junlei Yin   +4 more
wiley   +1 more source

Human Salmonella Typhi exposure generates differential multifunctional cross‐reactive T‐cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella

Clinical &Translational Immunology, Volume 9, Issue 9, 2020., 2020
Vaccines are lacking against several of the major causes of invasive Salmonella disease, such as invasive nontyphoidal Salmonella and S. Paratyphi A. These studies demonstrate that T memory cell effector responses generated after human wt Salmonella Typhi mucosal infection are multifunctional and cross‐reactive against S. Paratyphi A, S.
Rekha R Rapaka, Rezwanul Wahid, Stephanie Fresnay, Jayaum S Booth, Thomas C Darton, Claire Jones, Claire S Waddington, Myron M Levine, Andrew J Pollard, Marcelo B Sztein   +9 more
wiley   +1 more source

Extensively Drug‐Resistant (XDR) Typhoid: Evolution, Prevention, and Its Management

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Typhoid fever is the result of a human host‐restricted Salmonella enteric serotype typhi infection that causes enteric fever. Around 21 million people contract typhoid annually, with Pakistan’s inhabitants at most risk amongst Asian countries where typhoid remains prevalent.
Javed Akram, Arsalan Shamim Khan, Hassan Ahmed Khan, Syed Amir Gilani, Shehla Javed Akram, Fridoon Jawad Ahmad, Riffat Mehboob, Oguz R. Sipahi   +7 more
wiley   +1 more source

Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model.

PLoS Neglected Tropical Diseases, 2020
Enteric fever is a systemic infection caused by Salmonella Typhi or Paratyphi A. In many endemic areas, these serovars co-circulate and can cause multiple infection-episodes in childhood.
Malick M Gibani, Celina Jin, Sonu Shrestha, Maria Moore, Lily Norman, Merryn Voysey, Elizabeth Jones, Luke Blackwell, Helena Thomaides-Brears, Jennifer Hill, Christoph J Blohmke, Hazel C Dobinson, Philip Baker, Claire Jones, Danielle Campbell, Yama F Mujadidi, Emma Plested, Lorena Preciado-Llanes, Giorgio Napolitani, Alison Simmons, Melita A Gordon, Brian Angus, Thomas C Darton, Vincenzo Cerundulo, Andrew J Pollard   +24 more
doaj   +1 more source

Phase II multicentre double-blind randomised controlled trial of a Bivalent VaccInation against Salmonella Typhi and Paratyphi A (BiVISTA) using a controlled human infection model of paratyphoid A infection: study protocol

BMJ Open
Introduction Enteric fever, primarily caused by Salmonella enterica Typhi and Salmonella enterica Paratyphi A (SPA), is endemic mainly in South Asia, disproportionately affecting school-age children.
Elizabeth Jones, Xinxue Liu, Andrew J Pollard, Brian Angus, Parvinder Aley, Eleanor Wilson, Hannah Robinson, Amy Flaxman, Prasad S Kulkarni, Nisha Singh, Naina McCann, Young Chan Kim, Margarete Paganotti Vicentine, Oisin Hennigan, Noshi Maria, Claudia I Juarez Molina, Stanislava Koleva, Mohammod K Islam, Nicole Day, Allison MacDonald, Mehreen Adnan, Sophie Vernon, Anirudha Vyankatesh Potey, Abhijeet Dharmadhikari, Sanket Gaidhane, Maheshi Nirmala Ramasamy   +25 more
doaj   +1 more source