Results 191 to 200 of about 568,389 (237)

Inhibitors of Tyrosinase

Journal of Experimental Biology, 1955
ABSTRACT It has been reported that if Drosophila larvae are ground to a fine paste with sand, the homogenate shows little tyrosinase activity, but that if the larvae are allowed to blacken in chloroform vapour before grinding, activity is increased.
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Biomedical applications of tyrosinases and tyrosinase inhibitors

Tyrosinase is involved in several human diseases, among which hypopigmentation and depigmentation conditions (vitiligo, idiopathic guttate hypomelanosis, pityriasis versicolor, pityriasis alba) and hyperpigmentations (melasma, lentigines, post-inflammatory and periorbital hyperpigmentation, cervical idiopathic poikiloderma and acanthosis nigricans ...
Luigi, Pisano, Martina, Turco, Claudiu T, Supuran   +2 more
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Tyrosinase inhibitors as potential antibacterial agents

European Journal of Medicinal Chemistry, 2020
Tyrosinase is a copper-containing enzyme that catalyzes the biosynthesis of melanin. This enzyme is present in bacteria, fungi, plants and animals, and plays multiple roles in pigmentation, wound healing, radiation protection, primary immune responses and the undesirable browning of fruits and vegetables.
Ye Yuan, Wanli Jin, Yasir Nazir, Christian Fercher, Mark A.T. Blaskovich, Matthew A. Cooper, Ross T. Barnard, Zyta M. Ziora   +7 more
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Bacterial tyrosinases and their inhibitors

Bacterial tyrosinase is a copper-containing metalloenzyme with diverse physio-chemical properties, that have been identified in various bacterial strains, including actinobacteria and proteobacteria. Tyrosinases are responsible for the rate-limiting catalytic steps in melanin biosynthesis and enzymatic browning.
Ali, Irfan, Yousef A, Bin Jardan, Laila, Rubab, Huma, Hameed, Ameer Fawad, Zahoor, Claudiu T, Supuran   +5 more
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Synthesis of glabridin derivatives as tyrosinase inhibitors

Archives of Pharmacal Research, 2009
A novel 3'',4''-dihydroglabridin was successfully prepared for studying on tyrosinase inhibitory activity. The result demonstrated that 3'',4''-dihydroglabridin exhibited higher activity than glabridin (IC(50) value = 11.40 microM), which is probably due to the 4-substituted resorcinol skeleton and the lacking of double bond between carbon atom 3'' and
Warunee, Jirawattanapong, Ekarin, Saifah, Chamnan, Patarapanich   +2 more
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Tetraketones: A new class of tyrosinase inhibitors

Bioorganic & Medicinal Chemistry, 2006
Twenty-eight tetraketones (1-28) with variable substituents at C-7 were synthesized and evaluated as tyrosinase inhibitors. Remarkably compounds 25 (IC(50)=2.06 microM), 11 (IC(50)=2.09 microM), 15 (IC(50)=2.61 microM), and 27 (IC(50)=3.19 microM) were found to be the most active compounds of the series, even better than both standards kojic acid (IC ...
Khalid Mohammed, Khan, Ghulam Murtaza, Maharvi, Mahmud Tareq Hassan, Khan, Ahson, Jabbar Shaikh, Shahnaz, Perveen, Saeedan, Begum, Mohammad Iqbal, Choudhary   +6 more
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Discovery of small-molecule inhibitors of tyrosinase

Bioorganic & Medicinal Chemistry Letters, 2007
To identify novel inhibitors of tyrosinase, a fluorescent assay was developed which is suitable for high-throughput screening. In the assay, oxidation of the substrate by tyrosinase leads to the release of a fluorescent coumarin. Several small molecules were identified that inhibited mushroom tyrosinase in vitro and human tyrosinase in cell culture ...
Juris P, Germanas, Shugauang, Wang, Andrew, Miner, Wayne, Hao, Joseph M, Ready   +4 more
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New halogenated phenylcoumarins as tyrosinase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2011
With the aim to find out structural features for the tyrosinase inhibitory activity, in the present communication we report the synthesis and pharmacological evaluation of a new series of phenylcoumarin derivatives with different number of hydroxyl or ether groups and bromo substituent in the scaffold.
Matos MJ, Santana L, Uriarte E, DELOGU, GIOVANNA LUCIA, CORDA, MARCELLA, Fadda MB, ERA, BENEDETTA, FAIS, ANTONELLA   +7 more
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Drug design of tyrosinase inhibitors

This copper-containing enzyme catalyzes the rate-limiting step for the melanin skin pigment bioproduction. Tyrosinase inhibitors can be exploited as skin whitening agents and food preservatives, opening new scenarios in food, cosmetics, agriculture and medicine.
Melfi F., Carradori S., Granese A., Osmanovic A., Campestre C.   +4 more
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Computational studies of tyrosinase inhibitors

Computational studies have significantly advanced the understanding of tyrosinase (TYR) function, mechanism, and inhibition, accelerating the development of more effective and selective inhibitors. This chapter provides an overview of in silico studies on TYR inhibitors, emphasizing key inhibitory chemotypes and the main residues involved in ligand ...
Alessandro, Bonardi, Paola, Gratteri
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