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An Updated Review of Tyrosinase Inhibitors [PDF]

International Journal of Molecular Sciences, 2009
Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable.
Te-Sheng Chang
exaly   +4 more sources

A Comprehensive Review on Tyrosinase Inhibitors [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and plays an important role in the melanogenesis and enzymatic browning. Therefore, its inhibitors can be attractive in cosmetics and medicinal industries as depigmentation agents and also in food and agriculture industries as antibrowning compounds. For this purpose,
Francisco Garcia-Canovas, Ali Akbar Saboury, Samaneh Zolghadri   +2 more
exaly   +4 more sources

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Tyrosinase and Tyrosinase Inhibitors

Journal of Biocatalysis & Biotransformation, 2012
Tyrosinase and Tyrosinase Inhibitors Melanin is responsible for skin color and plays an important role in protection of the skin against UV light induced damage. During the melanin biosynthesis pathway, tyrosinase (EC 1.14.18.1) is the rate-limiting enzyme that hydroxylates L-tyrosine to L-3,4- dihydroxyphenylalanine (L-DOPA), and L-DOPA is further ...
openaire   +1 more source

Thiosemicarbazones as inhibitors of tyrosinase enzyme

Bioorganic & Medicinal Chemistry Letters, 2017
In the search for compounds which may inhibit the development of melanomas, a series of thiosemicarbazones has been investigated as possible inhibitors of the tyrosinase enzyme. The results showed that all the thiosemicarbazones tested exhibited significant inhibitory effects on the enzyme.
Mariana A, Soares, Mariana A, Almeida, Carla, Marins-Goulart, Otávio A, Chaves, Aurea, Echevarria, Márcia C C, de Oliveira   +5 more
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Recent advances in triazoles as tyrosinase inhibitors

European Journal of Medicinal Chemistry, 2023
The tyrosinase enzyme, which is widely found in microorganisms, animals and plants, has a significant position in melanogenesis, plays an important role in undesirable browning of fruits and vegetables, antibiotic resistance, skin pigment formation, sclerotization of cuticle, neurodegeneration, etc. Therefore, with the wide potential application fields
Arif Mermer, Serpil Demirci
openaire   +2 more sources

Prenylated flavonoids as tyrosinase inhibitors

Archives of Pharmacal Research, 2004
In order to find new tyrosinase inhibitors and the effects of prenyl residue on flavonoid molecules, eight prenylated and three synthetic vinylated flavonoids were examined on their inhibitory effect against tyrosinase activity. From the results, kuwanon C, papyriflavonol A, sanggenon D and sophoflavescenol were found to possess the considerable ...
Nan Kyoung, Lee, Kun Ho, Son, Hyeun Wook, Chang, Sam Sik, Kang, Haeil, Park, Moon Young, Heo, Hyun Pyo, Kim   +6 more
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Inhibitors of Tyrosinase

Journal of Experimental Biology, 1955
ABSTRACT It has been reported that if Drosophila larvae are ground to a fine paste with sand, the homogenate shows little tyrosinase activity, but that if the larvae are allowed to blacken in chloroform vapour before grinding, activity is increased.
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Tyrosinase inhibitors as potential antibacterial agents

European Journal of Medicinal Chemistry, 2020
Tyrosinase is a copper-containing enzyme that catalyzes the biosynthesis of melanin. This enzyme is present in bacteria, fungi, plants and animals, and plays multiple roles in pigmentation, wound healing, radiation protection, primary immune responses and the undesirable browning of fruits and vegetables.
Ye Yuan, Wanli Jin, Yasir Nazir, Christian Fercher, Mark A.T. Blaskovich, Matthew A. Cooper, Ross T. Barnard, Zyta M. Ziora   +7 more
openaire   +5 more sources

Biomedical applications of tyrosinases and tyrosinase inhibitors

Tyrosinase is involved in several human diseases, among which hypopigmentation and depigmentation conditions (vitiligo, idiopathic guttate hypomelanosis, pityriasis versicolor, pityriasis alba) and hyperpigmentations (melasma, lentigines, post-inflammatory and periorbital hyperpigmentation, cervical idiopathic poikiloderma and acanthosis nigricans ...
Luigi, Pisano, Martina, Turco, Claudiu T, Supuran   +2 more
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Bacterial tyrosinases and their inhibitors

Bacterial tyrosinase is a copper-containing metalloenzyme with diverse physio-chemical properties, that have been identified in various bacterial strains, including actinobacteria and proteobacteria. Tyrosinases are responsible for the rate-limiting catalytic steps in melanin biosynthesis and enzymatic browning.
Ali, Irfan, Yousef A, Bin Jardan, Laila, Rubab, Huma, Hameed, Ameer Fawad, Zahoor, Claudiu T, Supuran   +5 more
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