Results 1 to 10 of about 1,478,602 (406)

Long-Term Hyperglycemia Causes Depressive Behaviors in Mice with Hypoactive Glutamatergic Activity in the Medial Prefrontal Cortex, Which Is Not Reversed by Insulin Treatment

Cells, 2022
The etiology of hyperglycemic-induced depressive behaviors is unclear. We hypothesized that long-term hyperglycemia may induce long-lasting disturbances in glutamatergic signaling and neural damages, causing depressive behaviors. To prove our hypothesis,
Ji Hyeong Baek, Hyeonwi Son, Jae Soon Kang, Dae Young Yoo, Hye Jin Chung, Dong Kun Lee, Hyun Joon Kim   +6 more
doaj   +1 more source

Demonstrating a link between diet, gut microbiota and brain: 14C radioactivity identified in the brain following gut microbial fermentation of 14C-radiolabeled tyrosine in a pig model

Frontiers in Nutrition, 2023
BackgroundThere is a need to better understand the relationship between the diet, the gut microbiota and mental health. Metabolites produced when the human gut microbiota metabolize amino acids may enter the bloodstream and have systemic effects.
Margaret Murray, Margaret Murray, Christopher K. Barlow, Scott Blundell, Mark Buecking, Anne Gibbon, Bernd Goeckener, Lisa M. Kaminskas, Patricia Leitner, Sophie Selby-Pham, Andrew Sinclair, Habtewold D. Waktola, Habtewold D. Waktola, Gary Williamson, Louise E. Bennett   +14 more
doaj   +1 more source

Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Biosensors, 2021
The rapid growth of research in electrochemistry in the last decade has resulted in a significant advancement in exploiting electrochemical strategies for assessing biological substances.
Kaveh Moulaee, Giovanni Neri
doaj   +1 more source

Tyrosine Amino Acid as a Foulant for the Heterogeneous Anion Exchange Membrane

Membranes, 2023
The features of organic fouling have been revealed for highly basic anion exchange membranes during prolonged electrodialysis in solutions containing the aromatic amino acid tyrosine. With increased operation time when using MA-41 heterogeneous membranes
Anastasiia Kharina, Tatiana Eliseeva
doaj   +1 more source

Non-cytotoxic Dityrosine Photocrosslinked Polymeric Materials With Targeted Elastic Moduli

Frontiers in Chemistry, 2020
Controlling mechanical properties of polymeric biomaterials, including the elastic modulus, is critical to direct cell behavior, such as proliferation and differentiation.
Christopher P. Camp, Ingrid L. Peterson, Ingrid L. Peterson, David S. Knoff, Lauren G. Melcher, Connor J. Maxwell, Audrey T. Cohen, Anne M. Wertheimer, Anne M. Wertheimer, Minkyu Kim, Minkyu Kim, Minkyu Kim   +11 more
doaj   +1 more source

Role of cytosolic, tyrosine‐insensitive prephenate dehydrogenase in Medicago truncatula

Plant Direct, 2020
l‐Tyrosine (Tyr) is an aromatic amino acid synthesized de novo in plants and microbes downstream of the shikimate pathway. In plants, Tyr and a Tyr pathway intermediate, 4‐hydroxyphenylpyruvate (HPP), are precursors to numerous specialized metabolites ...
Craig A. Schenck, Josh Westphal, Dhileepkumar Jayaraman, Kevin Garcia, Jiangqi Wen, Kirankumar S. Mysore, Jean‐Michel Ané, Lloyd W. Sumner, Hiroshi A. Maeda   +8 more
doaj   +1 more source

Phosphomimetic Tyrosine Mutations in Spa47 Inhibit Type Three Secretion ATPase Activity and Shigella Virulence Phenotype

Pathogens, 2022
Shigella is a highly infectious human pathogen responsible for 269 million infections and 200,000 deaths per year. Shigella virulence is absolutely reliant on the injection of effector proteins into the host cell cytoplasm via its type three secretion ...
Koleton D. Hardy, Nicholas E. Dickenson
doaj   +1 more source

Hydrogels and Cubic Liquid Crystals for Non-Invasive Sampling of Low-Molecular-Weight Biomarkers—An Explorative In Vivo Study

Pharmaceutics, 2022
The molecular composition of human skin is altered due to diseases, which can be utilized for non-invasive sampling of biomarkers and disease diagnostics.
Maxim Morin, Skaidre Jankovskaja, Tautgirdas Ruzgas, Joakim Henricson, Chris D. Anderson, Anders Brinte, Johan Engblom, Sebastian Björklund   +7 more
doaj   +1 more source

The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src [PDF]

, 2007
The transmembrane receptor 'ROR2' resembles members of the receptor tyrosine kinase family of signalling receptors in sequence but its' signal transduction mechanisms remain enigmatic.
A Schambony, AJ Mikels, AR Afzal, Faraz Khosravi Mardakheh, GC Schwabe, H Hikasa, H van Bokhoven, I Oishi, I Oishi, J Billiard, J Liu, John K. Heath, JP Gorvel, K Alexandropoulos, Lee M. Wheldon, M Miaczynska, M Nishita, M Oldridge, M Sammar, MR Larsen, P Masiakowski, R Ishizawar, Richard Steinhardt, S Stricker, S Takeuchi, SA Beausoleil, Shiva Akbarzadeh, Sonia Talma, Steve M. M. Sweet, TM DeChiara, WC Forrester, Y Liu, Z Songyang   +32 more
core   +8 more sources

Association of alkaptonuria and low dose nitisinone therapy with cataract formation in a large cohort of patients

JIMD Reports, 2022
Homogentisic acid (HGA) lowering, disease modifying off‐label nitisinone therapy has been used in the United Kingdom National Alkaptonuria Centre (NAC) since 2012.
Mohammad S. Z. Ahmad, Mahmoud Ahmed, Milad Khedr, Alfredo Borgia, Andrea Madden, Lakshminarayan R. Ranganath, Stephen Kaye   +6 more
doaj   +1 more source