Results 1 to 10 of about 1,001,494 (307)

Amino acid supplementation in mitochondrial aminoacyl-tRNA synthetase defects: two case reports of tyrosine supplementation in YARS2-associated disease and a review of the literature

Frontiers in Pediatrics
BackgroundMitochondrial diseases (MDs) caused by pathogenic variants in aminoacyl-tRNA synthetase (ARS) genes, either cytosolic (ARS1) or mitochondrial (ARS2), are rare and clinically diverse.
Giulia Ferrera, Giulia Ferrera, Giorgia Segre, Eleonora Lamantea, Daniele Ghezzi, Daniele Ghezzi, Marta Rivelli, Anna Ardissone   +7 more
doaj   +1 more source

Application of a risk score model based on tyrosine-related genes in the prognosis and treatment of patients with lung adenocarcinoma

Frontiers in Immunology
BackgroundTyrosine is associated with alterations in the tricarboxylic acid cycle in lung cancer, and exploring tyrosine-related genes (TRGs) has the potential to contribute to the construction of new sensitive prognostic biomarkers for patients with ...
Huan Wang, Yuebei Li, Ke Liu, Xinyuan Fan   +3 more
doaj   +1 more source

Serum tyrosine increases all-cause mortality in an older population

Frontiers in Endocrinology
PurposeAmino acids play crucial roles in metabolic and cardiovascular diseases, especially branched-chain and aromatic amino acids, but their association with mortality remains understudied and inconclusive.
Yuhong Dai, Yong Zhang, Yue Zhang, Haoran Zheng, Ling Xiang, Liang Cheng, Xiaoqing Wang, Jie Zhang, Hairong Hao, De Huai, Wen Hu   +10 more
doaj   +1 more source

Hypozincemia Is Associated With Increased Tyrosine Levels, Low Handgrip Strength, Increased Incidence of HCC, and Liver Disease Progression—A Cross‐Sectional Study

JGH Open
Background Serum zinc levels decrease in chronic liver disease (CLD), but their effects on liver reserve function, tyrosine, skeletal muscle mass, handgrip strength (HGS), and hepatocellular carcinoma (HCC) development remain poorly understood. Methods A
Tomoo Kobayashi, Jun Inoue, Yu Tanaka, Mitsuru Yamakawa, Makoto Kurihara, Tomoko Handa, Yutaka Kondo, Akihiro Saitou, Manabu Shiraki, Yasuhiro Kojima, Motoki Ohyauchi, Atsushi Masamune   +11 more
doaj   +1 more source

HS-Associated Pasteurella multocida Infection Disrupts Gut Microbiota and Metabolism in Mice

Microorganisms
Pasteurella multocida serotype B:2 is a primary agent of hemorrhagic septicemia (HS) in livestock, and the strain NQ01 isolated from yaks highlights its cross-species impact.
Kewei Li, Chao Jin, Haofang Yuan, Muhammad Farhan Rahim, Xire Luosong, Tianwu An, Jiakui Li   +6 more
doaj   +1 more source

TYROSINEMIA TYPE III: A CASE REPORT OF SIBLINGS AND LITERATURE REVIEW

Revista Paulista de Pediatria
Objective: Tyrosinemia type III (HT III) is the rarest form of tyrosinemia, and the full clinical spectrum of this disorder is still unknown. The neurological involvement varies, including intellectual impairment and attention deficit disorder with ...
Fábio Barroso, Joana Correia, Anabela Bandeira, Carla Carmona, Laura Vilarinho, Manuela Almeida, Júlio César Rocha, Esmeralda Martins   +7 more
doaj   +1 more source

Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation.

Cell, 1995
C. Marshall
semanticscholar   +1 more source

Association of phenylalanine and tyrosine metabolism with mortality and response to nutritional support among patients at nutritional risk: a secondary analysis of the randomized clinical trial EFFORT

Frontiers in Nutrition
BackgroundElevated phenylalanine serum level is a surrogate marker of whole-body proteolysis and has been associated with increased mortality in critically ill patients.
Lena C. Buchmueller, Lena C. Buchmueller, Carla Wunderle, Rahel Laager, Rahel Laager, Rahel Laager, Luca Bernasconi, Peter J. Neyer, Pascal Tribolet, Pascal Tribolet, Pascal Tribolet, Zeno Stanga, Beat Mueller, Beat Mueller, Philipp Schuetz, Philipp Schuetz   +15 more
doaj   +1 more source

mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.

Cancer Research, 2006
K. O'reilly, F. Rojo, Q. She, D. Solit, G. Mills, Debra L. Smith, H. Lane, F. Hofmann, D. Hicklin, D. Ludwig, J. Baselga, N. Rosen   +11 more
semanticscholar   +1 more source

Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma. [PDF]

Nat Commun
Zhang H, Wang Z, Zhao Y, Deng X, Zhang J, Shang F, Zhang H, Liu Y, Wang H, Yang Y, Lin H, Zhang B, Liu C, Guo F, Zhang R, Yuan Q, Feng Y, Luo SZ, Chen WD, Wang YD.   +19 more
europepmc   +1 more source