Results 1 to 10 of about 1,086,674 (386)

Hypozincemia Is Associated With Increased Tyrosine Levels, Low Handgrip Strength, Increased Incidence of HCC, and Liver Disease Progression—A Cross‐Sectional Study [PDF]

JGH Open
Background Serum zinc levels decrease in chronic liver disease (CLD), but their effects on liver reserve function, tyrosine, skeletal muscle mass, handgrip strength (HGS), and hepatocellular carcinoma (HCC) development remain poorly understood. Methods A
Tomoo Kobayashi, Jun Inoue, Yu Tanaka, Mitsuru Yamakawa, Makoto Kurihara, Tomoko Handa, Yutaka Kondo, Akihiro Saitou, Manabu Shiraki, Yasuhiro Kojima, Motoki Ohyauchi, Atsushi Masamune   +11 more
doaj   +2 more sources

Long-Term Hyperglycemia Causes Depressive Behaviors in Mice with Hypoactive Glutamatergic Activity in the Medial Prefrontal Cortex, Which Is Not Reversed by Insulin Treatment

Cells, 2022
The etiology of hyperglycemic-induced depressive behaviors is unclear. We hypothesized that long-term hyperglycemia may induce long-lasting disturbances in glutamatergic signaling and neural damages, causing depressive behaviors. To prove our hypothesis,
Ji Hyeong Baek, Hyeonwi Son, Jae Soon Kang, Dae Young Yoo, Hye Jin Chung, Dong Kun Lee, Hyun Joon Kim   +6 more
doaj   +1 more source

Tyrosine-Dependent Phenotype Switching Occurs Early in Many Primary Melanoma Cultures Limiting Their Translational Value

Frontiers in Oncology, 2021
The use of patient-derived primary cell cultures in cancer preclinical assays, including drug screens and genotoxic studies, has increased in recent years.
Ahmad Najem, Jasper Wouters, Jasper Wouters, Mohammad Krayem, Florian Rambow, Florian Rambow, Malak Sabbah, François Sales, François Sales, Ahmad Awada, Ahmad Awada, Stein Aerts, Stein Aerts, Fabrice Journe, Fabrice Journe, Jean-Christophe Marine, Jean-Christophe Marine, Ghanem E. Ghanem   +17 more
doaj   +1 more source

Demonstrating a link between diet, gut microbiota and brain: 14C radioactivity identified in the brain following gut microbial fermentation of 14C-radiolabeled tyrosine in a pig model

Frontiers in Nutrition, 2023
BackgroundThere is a need to better understand the relationship between the diet, the gut microbiota and mental health. Metabolites produced when the human gut microbiota metabolize amino acids may enter the bloodstream and have systemic effects.
Margaret Murray, Margaret Murray, Christopher K. Barlow, Scott Blundell, Mark Buecking, Anne Gibbon, Bernd Goeckener, Lisa M. Kaminskas, Patricia Leitner, Sophie Selby-Pham, Andrew Sinclair, Habtewold D. Waktola, Habtewold D. Waktola, Gary Williamson, Louise E. Bennett   +14 more
doaj   +1 more source

Non-cytotoxic Dityrosine Photocrosslinked Polymeric Materials With Targeted Elastic Moduli

Frontiers in Chemistry, 2020
Controlling mechanical properties of polymeric biomaterials, including the elastic modulus, is critical to direct cell behavior, such as proliferation and differentiation.
Christopher P. Camp, Ingrid L. Peterson, Ingrid L. Peterson, David S. Knoff, Lauren G. Melcher, Connor J. Maxwell, Audrey T. Cohen, Anne M. Wertheimer, Anne M. Wertheimer, Minkyu Kim, Minkyu Kim, Minkyu Kim   +11 more
doaj   +1 more source

Tyrosine Amino Acid as a Foulant for the Heterogeneous Anion Exchange Membrane

Membranes, 2023
The features of organic fouling have been revealed for highly basic anion exchange membranes during prolonged electrodialysis in solutions containing the aromatic amino acid tyrosine. With increased operation time when using MA-41 heterogeneous membranes
Anastasiia Kharina, Tatiana Eliseeva
doaj   +1 more source

Roaming leads to amino acid photodamage: A deep learning study of tyrosine [PDF]

, 2021
Although the amino acid tyrosine is among the main building blocks of life, its photochemistry is not fully understood. Traditional theoretical simulations are neither accurate enough, nor computationally efficient to provide the missing puzzle pieces to the experimentally observed signatures obtained via time-resolved pump-probe spectroscopy or mass ...
arxiv   +1 more source

Endosymbiosis allows Sitophilus oryzae to persist in dry conditions

Frontiers in Microbiology, 2023
Insects frequently associate with intracellular microbial symbionts (endosymbionts) that enhance their ability to cope with challenging environmental conditions. Endosymbioses with cuticle-enhancing microbes have been reported in several beetle families.
Sthandiwe Nomthandazo Kanyile, Tobias Engl, Abdelaziz Heddi, Martin Kaltenpoth   +3 more
doaj   +1 more source

Association of alkaptonuria and low dose nitisinone therapy with cataract formation in a large cohort of patients

JIMD Reports, 2022
Homogentisic acid (HGA) lowering, disease modifying off‐label nitisinone therapy has been used in the United Kingdom National Alkaptonuria Centre (NAC) since 2012.
Mohammad S. Z. Ahmad, Mahmoud Ahmed, Milad Khedr, Alfredo Borgia, Andrea Madden, Lakshminarayan R. Ranganath, Stephen Kaye   +6 more
doaj   +1 more source

Síndrome de Fanconi e hepatocarcinoma por tirosinemia tipo 1: relato de caso e revisão de literatura

Residência Pediátrica, 2023
INTRODUCTION: Type 1 tyrosinemia is an innate error of tyrosine catabolism, causing an accumulation of its metabolites in the organism, which end up triggering organic changes, especially in the liver, kidneys and central nervous system.
Maria Eduarda Turczyn De Lucca, Jhulia Farinha Maffini, Mariana Guerrini Grassi, Vinícius Neves Bezerra, Paulo Ramos David João, Mara Lúcia Schmitz Ferreira Santos, Sandra Lúcia Schuler   +6 more
doaj   +1 more source