Results 91 to 100 of about 1,001,494 (307)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Transcriptomic insights into the effects of tyrosine on sub-Columbian plumage in H line chickens
Frontiers in Veterinary ScienceTyrosine is known to influence melanin generation; however, its involvement in melanin production in chicken feathers is unknown. We evaluated the feather color of H-line chickens fed diets containing different concentrations of tyrosine (0, 0.4, 0.6, 0 ...
Xinlei Wang +17 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Veterinary SciencesThe objective of this study was to evaluate the effect of tyrosine on behavior and ruminal meta-taxonomic profile of Altay sheep. Twelve rams with the lowest behavioral responses to humans and twelve rams with the highest behavioral responses were sorted
Asmita Thapa +6 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Cell signaling by receptor tyrosine kinases.
Cell, 2000 J. Schlessinger
semanticscholar +2 more sources
Peptide Tyrosine-Tyrosine (PYY) — An Evolutionary Perspective [PDF]
American Zoologist, 1995 The hormone peptide tyrosine-tyrosine (PYY), first isolated from pig intestine, islocalized to endocrine cells in the lower bowel and exercises a predominantly inhibitory actionon gastro-intestinal function. Mammalian tissues also produce the homologous peptides neuropeptide Y, localized to central and peripheral neurons, and pancreatic polypeptide ...
openaire +1 more source
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source
Journal of Horticultural Research, 2013 There is interest in increasing the yield and pigment content of beetroot and red beet since conventional agronomic practices or breeding efforts have not produced satisfactory results. Using a local cultivar of red beet (Beta vulgaris L. subsp.
El-Sherbeny M. Rashad +1 more
doaj +1 more source
The Characteristics of Intrinsic Fluorescence of Type I Collagen Influenced by Collagenase I
Applied Sciences, 2018 The triple helix structure of collagen can be degraded by collagenase. In this study, we explored how the intrinsic fluorescence of type I collagen was influenced by collagenase I. We found that tyrosine was the main factor that could successfully excite
Yiming Shen +5 more
doaj +1 more source