Results 11 to 20 of about 1,534,933 (399)

Amino acid supplementation in mitochondrial aminoacyl-tRNA synthetase defects: two case reports of tyrosine supplementation in YARS2-associated disease and a review of the literature [PDF]

Frontiers in Pediatrics
BackgroundMitochondrial diseases (MDs) caused by pathogenic variants in aminoacyl-tRNA synthetase (ARS) genes, either cytosolic (ARS1) or mitochondrial (ARS2), are rare and clinically diverse.
Giulia Ferrera, Giulia Ferrera, Giorgia Segre, Eleonora Lamantea, Daniele Ghezzi, Daniele Ghezzi, Marta Rivelli, Anna Ardissone   +7 more
doaj   +2 more sources

Application of a risk score model based on tyrosine-related genes in the prognosis and treatment of patients with lung adenocarcinoma [PDF]

Frontiers in Immunology
BackgroundTyrosine is associated with alterations in the tricarboxylic acid cycle in lung cancer, and exploring tyrosine-related genes (TRGs) has the potential to contribute to the construction of new sensitive prognostic biomarkers for patients with ...
Huan Wang, Yuebei Li, Ke Liu, Xinyuan Fan   +3 more
doaj   +2 more sources

Long-Term Hyperglycemia Causes Depressive Behaviors in Mice with Hypoactive Glutamatergic Activity in the Medial Prefrontal Cortex, Which Is Not Reversed by Insulin Treatment

Cells, 2022
The etiology of hyperglycemic-induced depressive behaviors is unclear. We hypothesized that long-term hyperglycemia may induce long-lasting disturbances in glutamatergic signaling and neural damages, causing depressive behaviors. To prove our hypothesis,
Ji Hyeong Baek, Hyeonwi Son, Jae Soon Kang, Dae Young Yoo, Hye Jin Chung, Dong Kun Lee, Hyun Joon Kim   +6 more
doaj   +1 more source

Tyrosine-Dependent Phenotype Switching Occurs Early in Many Primary Melanoma Cultures Limiting Their Translational Value

Frontiers in Oncology, 2021
The use of patient-derived primary cell cultures in cancer preclinical assays, including drug screens and genotoxic studies, has increased in recent years.
Ahmad Najem, Jasper Wouters, Jasper Wouters, Mohammad Krayem, Florian Rambow, Florian Rambow, Malak Sabbah, François Sales, François Sales, Ahmad Awada, Ahmad Awada, Stein Aerts, Stein Aerts, Fabrice Journe, Fabrice Journe, Jean-Christophe Marine, Jean-Christophe Marine, Ghanem E. Ghanem   +17 more
doaj   +1 more source

The SYK tyrosine kinase: a crucial player in diverse biological functions

Nature Reviews Immunology, 2010
Attila Mócsai, Jürgen Ruland, Victor L J Tybulewicz   +2 more
exaly   +2 more sources

Phosphomimetic Tyrosine Mutations in Spa47 Inhibit Type Three Secretion ATPase Activity and Shigella Virulence Phenotype

Pathogens, 2022
Shigella is a highly infectious human pathogen responsible for 269 million infections and 200,000 deaths per year. Shigella virulence is absolutely reliant on the injection of effector proteins into the host cell cytoplasm via its type three secretion ...
Koleton D. Hardy, Nicholas E. Dickenson
doaj   +1 more source

Hydrogels and Cubic Liquid Crystals for Non-Invasive Sampling of Low-Molecular-Weight Biomarkers—An Explorative In Vivo Study

Pharmaceutics, 2022
The molecular composition of human skin is altered due to diseases, which can be utilized for non-invasive sampling of biomarkers and disease diagnostics.
Maxim Morin, Skaidre Jankovskaja, Tautgirdas Ruzgas, Joakim Henricson, Chris D. Anderson, Anders Brinte, Johan Engblom, Sebastian Björklund   +7 more
doaj   +1 more source

Roles of the tyrosine isomers meta- tyrosine and ortho- tyrosine in oxidative stress [PDF]

Ageing Research Reviews, 2016
The damage to cellular components by reactive oxygen species, termed oxidative stress, both increases with age and likely contributes to age-related diseases including Alzheimer's disease, atherosclerosis, diabetes, and cataract formation. In the setting of oxidative stress, hydroxyl radicals can oxidize the benzyl ring of the amino acid phenylalanine,
Brett R, Ipson, Alfred L, Fisher
openaire   +2 more sources

The Effect of the Acidic Gas Pollutant on Wool Keratin Fiber Structure

Journal of Natural Fibers, 2022
Increase in air pollution caused by acidic gases, such as nitrogen dioxide, call for the need to study potential effects on the structure of textile materials.
Zhe Jiang, Rubing Bai, Jinfang Zhang, Ende Li, Yifan Cui, Ning Zhang, Nan Zhang, Qiang Wang   +7 more
doaj   +1 more source

Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Biosensors, 2021
The rapid growth of research in electrochemistry in the last decade has resulted in a significant advancement in exploiting electrochemical strategies for assessing biological substances.
Kaveh Moulaee, Giovanni Neri
doaj   +1 more source