Results 21 to 30 of about 1,001,494 (307)

The SYK tyrosine kinase: a crucial player in diverse biological functions

Nature Reviews Immunology, 2010
Attila Mócsai, Victor L J Tybulewicz
exaly   +2 more sources

Tyrosine Kinases as Targets for Cancer Therapy

New England Journal of Medicine, 2005
Daniela S Krause, Richard A Van Etten
exaly   +2 more sources

Screening and Structure–Activity Relationship for Selective and Potent Anti-Melanogenesis Agents Derived from Species of Mulberry (Genus Morus)

Molecules, 2022
Tyrosinase is a multifunctional, copper-containing and rate-limiting oxidase that catalyses crucial steps in the melanogenesis pathway and is responsible for skin-pigmentation abnormalities in mammals.
Anna Gryn-Rynko, Beata Sperkowska, Michał S. Majewski   +2 more
doaj   +1 more source

Method development and validation for analysis of phenylalanine, 4‐hydroxyphenyllactic acid and 4‐hydroxyphenylpyruvic acid in serum and urine

JIMD Reports, 2022
Alkaptonuria (AKU) is a rare debilitating autosomal recessive disorder of tyrosine (TYR) metabolism which results in a deficiency of the enzyme homogentisate 1,2‐dioxygenase activity.
Andrew T. Hughes, Anna M. Milan, Ella Shweihdi, James Gallagher, Lakshminarayan Ranganath   +4 more
doaj   +1 more source

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

Frontiers in Public Health, 2023
BackgroundPrevious research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and ...
John Tyler, John Tyler, Madeline Podaras, Madeline Podaras, Brittany Richardson, Brittany Richardson, Nicole Roeder, Nicole Roeder, Nikki Hammond, John Hamilton, Kenneth Blum, Mark Gold, David A. Baron, Panayotis K. Thanos, Panayotis K. Thanos   +14 more
doaj   +1 more source

Archaeal tyrosine recombinases

FEMS Microbiology Reviews, 2021
ABSTRACTThe integration of mobile genetic elements into their host chromosome influences the immediate fate of cellular organisms and gradually shapes their evolution. Site-specific recombinases catalyzing this integration have been extensively characterized both in bacteria and eukarya.
Badel, Catherine, da Cunha, Violette, Oberto, J.   +2 more
openaire   +2 more sources

Curcumin-driven reprogramming of the gut microbiota and metabolome ameliorates motor deficits and neuroinflammation in a mouse model of Parkinson’s disease

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundParkinson’s disease (PD) is a common neurodegenerative disorder, accompanied by motor deficits as well as gastrointestinal dysfunctions.
Can Cui, Yingying Han, Hongxia Li, Hongxiang Yu, Bei Zhang, Gang Li   +5 more
doaj   +1 more source

The Vav GEF Family: An Evolutionary and Functional Perspective

Cells, 2019
Vav proteins play roles as guanosine nucleotide exchange factors for Rho GTPases and signaling adaptors downstream of protein tyrosine kinases. The recent sequencing of the genomes of many species has revealed that this protein family originated in ...
Sonia Rodríguez-Fdez, Xosé R. Bustelo
doaj   +1 more source

Hierarchical graphene oxide-Ni3S2 quantum dots nanocomposites modified glassy carbon electrode for electrochemical detection of dopamine and tyrosine

Frontiers in Materials, 2023
A facile synthetic strategy is demonstrated to generate nickel sulfide quantum dots (Ni3S2). The thus formed Ni3S2 quantum dots are assembled onto exfoliated graphene oxide sheets hydrothermally to form nickel sulfide-graphene oxide nanocomposite ...
M. Hasheena, A. Ratnamala, M. Noorjahan, G. Deepthi Reddy, Gousia Begum   +4 more
doaj   +1 more source

Tyrosine kinase inhibitors for solid tumors in the past 20 years (2001–2020)

Journal of Hematology & Oncology, 2020
Tyrosine kinases are implicated in tumorigenesis and progression, and have emerged as major targets for drug discovery. Tyrosine kinase inhibitors (TKIs) inhibit corresponding kinases from phosphorylating tyrosine residues of their substrates and then ...
Liling Huang, Shiyu Jiang, Yuankai Shi
semanticscholar   +1 more source