Results 21 to 30 of about 1,021,136 (197)
JIMD Reports, 2022 Alkaptonuria (AKU) is a rare debilitating autosomal recessive disorder of tyrosine (TYR) metabolism which results in a deficiency of the enzyme homogentisate 1,2‐dioxygenase activity.
Andrew T. Hughes +4 more
doaj +1 more source
Frontiers in Public Health, 2023 BackgroundPrevious research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and ...
John Tyler +14 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 BackgroundParkinson’s disease (PD) is a common neurodegenerative disorder, accompanied by motor deficits as well as gastrointestinal dysfunctions.
Can Cui +5 more
doaj +1 more source
The Vav GEF Family: An Evolutionary and Functional Perspective
Cells, 2019 Vav proteins play roles as guanosine nucleotide exchange factors for Rho GTPases and signaling adaptors downstream of protein tyrosine kinases. The recent sequencing of the genomes of many species has revealed that this protein family originated in ...
Sonia Rodríguez-Fdez, Xosé R. Bustelo
doaj +1 more source
Frontiers in Materials, 2023 A facile synthetic strategy is demonstrated to generate nickel sulfide quantum dots (Ni3S2). The thus formed Ni3S2 quantum dots are assembled onto exfoliated graphene oxide sheets hydrothermally to form nickel sulfide-graphene oxide nanocomposite ...
M. Hasheena +4 more
doaj +1 more source
Frontiers in Physiology, 2022 The increase of aquaculture production is associated with a growing interest in improving physiological status and welfare in fish. For this reason, the search for strategies for mitigating stress has been intensified, with one of these strategies being ...
Natalia Salamanca +6 more
doaj +1 more source
Tyrosine kinase inhibitors for solid tumors in the past 20 years (2001–2020)
Journal of Hematology & Oncology, 2020 Tyrosine kinases are implicated in tumorigenesis and progression, and have emerged as major targets for drug discovery. Tyrosine kinase inhibitors (TKIs) inhibit corresponding kinases from phosphorylating tyrosine residues of their substrates and then ...
Liling Huang, Shiyu Jiang, Yuankai Shi
semanticscholar +1 more source
Increased prevalence of Parkinson's disease in alkaptonuria
JIMD Reports, 2023 Amongst a cohort of 88 alkaptonuria (AKU) patients attending the United Kingdom National Alkaptonuria Centre (NAC), four unrelated patients had co‐existing Parkinson's disease (PD).
Lakshminarayan Ranganath +8 more
doaj +1 more source
Nature Communications, 2019 Human gut microbiota senses its environment and responds by releasing metabolites, some of which are key regulators of human health and disease. In this study, we characterize gut-associated bacteria in their ability to decarboxylate levodopa to dopamine
S. V. van Kessel +6 more
semanticscholar +1 more source
Applied Sciences, 2018 The nonprotein amino acid Levo-3,4-dihydroxyphenylalanine (L-DOPA) has insecticidal, allelochemical, and antiparkinsonian effects. The aim of this research was to assess L-DOPA content in different tissues of Vicia faba (cv.
Claudia A. Oviedo-Silva +2 more
doaj +1 more source