Results 41 to 50 of about 1,021,136 (197)

Phosphomimetic Tyrosine Mutations in Spa47 Inhibit Type Three Secretion ATPase Activity and Shigella Virulence Phenotype

Pathogens, 2022
Shigella is a highly infectious human pathogen responsible for 269 million infections and 200,000 deaths per year. Shigella virulence is absolutely reliant on the injection of effector proteins into the host cell cytoplasm via its type three secretion ...
Koleton D. Hardy, Nicholas E. Dickenson
doaj   +1 more source

Hydrogels and Cubic Liquid Crystals for Non-Invasive Sampling of Low-Molecular-Weight Biomarkers—An Explorative In Vivo Study

Pharmaceutics, 2022
The molecular composition of human skin is altered due to diseases, which can be utilized for non-invasive sampling of biomarkers and disease diagnostics.
Maxim Morin, Skaidre Jankovskaja, Tautgirdas Ruzgas, Joakim Henricson, Chris D. Anderson, Anders Brinte, Johan Engblom, Sebastian Björklund   +7 more
doaj   +1 more source

Detection of tyrosine phosphorylated proteins in trichinella spiralis L1 larvae

Parasite, 2001
Western-blotting analysis showed the presence of tyrosine phosphorylated proteins in crude extracts of T. spiralis larvae and these phosphorylated proteins were located by immunofluorescence on the striations of the larval cuticle.
Allegretti S., Beaumont V., Robert-Gangneux F., Creuzet C., Roisin M.P., Dupouy-Camet J.   +5 more
doaj   +1 more source

Biosynthesis of food constituents: Amino acids: 2. The alanine-valine-leucine, serine-cysteine-glycine, and aromatic and heterocyclic amino acids groups - a review

Czech Journal of Food Sciences, 2006
This review article gives a survey of principal pathways that lead to the biosynthesis of the proteinogenic amino acids of the alanine-valine-leucine group starting with pyruvic acid from the glycolytic pathway and serine-cysteine-glycine group starting ...
Jan Velíšek, Karel Cejpek
doaj   +1 more source

The Effect of the Acidic Gas Pollutant on Wool Keratin Fiber Structure

Journal of Natural Fibers, 2022
Increase in air pollution caused by acidic gases, such as nitrogen dioxide, call for the need to study potential effects on the structure of textile materials.
Zhe Jiang, Rubing Bai, Jinfang Zhang, Ende Li, Yifan Cui, Ning Zhang, Nan Zhang, Qiang Wang   +7 more
doaj   +1 more source

Deuterium isotope effects in mechanistic studies of biotransformations of l-tyrosine and p-hydroxyphenylpyruvic acid catalyzed by the enzyme l-phenylalanine dehydrogenase

Nukleonika
The mechanisms of the reversible oxidative deamination of l-tyrosine to p-hydroxyphenylpyruvic acid and reductive amination of phenylpyruvic acid to l-phenylalanine, both catalyzed by the enzyme l-phenylalanine dehydrogenase (PheDH, EC 1.4.1.20), were ...
Pałka Katarzyna, Podsadni Katarzyna, Szymańska-Majchrzak Jolanta, Winnicka Elżbieta   +3 more
doaj   +1 more source

Impact of Altered Intestinal Microbiota on Chronic Kidney Disease Progression

Toxins, 2018
In chronic kidney disease (CKD), accumulation of uremic toxins is associated with an increased risk of CKD progression. Some uremic toxins result from nutrient processing by gut microbiota, yielding precursors of uremic toxins or uremic toxins themselves,
Esmeralda Castillo-Rodriguez, Raul Fernandez-Prado, Raquel Esteras, Maria Vanessa Perez-Gomez, Carolina Gracia-Iguacel, Beatriz Fernandez-Fernandez, Mehmet Kanbay, Alberto Tejedor, Alberto Lazaro, Marta Ruiz-Ortega, Emilio Gonzalez-Parra, Ana B. Sanz, Alberto Ortiz, Maria Dolores Sanchez-Niño   +13 more
doaj   +1 more source

Evaluation of the serum metabolome of patients with alkaptonuria before and after two years of treatment with nitisinone using LC‐QTOF‐MS

JIMD Reports, 2019
Background The homogentisic acid‐lowering therapy nitisinone is being evaluated for the treatment of alkaptonuria (AKU) at the National Centre for AKU. Beyond hypertyrosinemia, the wider metabolic consequences of its use are largely unknown.
Andrew S. Davison, Brendan P. Norman, Gordon A. Ross, Andrew T. Hughes, Milad Khedr, Anna M. Milan, James A. Gallagher, Lakshminarayan R. Ranganath   +7 more
doaj   +1 more source

Electrochemical Amino Acid Sensing: A Review on Challenges and Achievements

Biosensors, 2021
The rapid growth of research in electrochemistry in the last decade has resulted in a significant advancement in exploiting electrochemical strategies for assessing biological substances.
Kaveh Moulaee, Giovanni Neri
doaj   +1 more source

Advances in studies of tyrosine kinase inhibitors and their acquired resistance

Molecular Cancer, 2018
Protein tyrosine kinase (PTK) is one of the major signaling enzymes in the process of cell signal transduction, which catalyzes the transfer of ATP-γ-phosphate to the tyrosine residues of the substrate protein, making it phosphorylation, regulating cell ...
Qinlian Jiao, Lei Bi, Yidan Ren, Shuliang Song, Qin Wang, Yun-shan Wang   +5 more
semanticscholar   +1 more source