Results 41 to 50 of about 1,534,933 (399)

Role of Bruton’s tyrosine kinase in B cells and malignancies

Molecular Cancer, 2018
Bruton’s tyrosine kinase (BTK) is a non-receptor kinase that plays a crucial role in oncogenic signaling that is critical for proliferation and survival of leukemic cells in many B cell malignancies. BTK was initially shown to be defective in the primary
Simar Pal Singh, Floris Dammeijer, R. Hendriks   +2 more
semanticscholar   +1 more source

Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development

Journal of Hematology & Oncology, 2018
Anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptors (PDGFR), and c-kit.
Guoshuang Shen, F. Zheng, Dengfeng Ren, F. Du, Qiuxia Dong, Ziyi Wang, Fuxing Zhao, Raees Ahmad, Jiuda Zhao   +8 more
semanticscholar   +1 more source

Non-cytotoxic Dityrosine Photocrosslinked Polymeric Materials With Targeted Elastic Moduli

Frontiers in Chemistry, 2020
Controlling mechanical properties of polymeric biomaterials, including the elastic modulus, is critical to direct cell behavior, such as proliferation and differentiation.
Christopher P. Camp, Ingrid L. Peterson, Ingrid L. Peterson, David S. Knoff, Lauren G. Melcher, Connor J. Maxwell, Audrey T. Cohen, Anne M. Wertheimer, Anne M. Wertheimer, Minkyu Kim, Minkyu Kim, Minkyu Kim   +11 more
doaj   +1 more source

Hierarchical graphene oxide-Ni3S2 quantum dots nanocomposites modified glassy carbon electrode for electrochemical detection of dopamine and tyrosine

Frontiers in Materials, 2023
A facile synthetic strategy is demonstrated to generate nickel sulfide quantum dots (Ni3S2). The thus formed Ni3S2 quantum dots are assembled onto exfoliated graphene oxide sheets hydrothermally to form nickel sulfide-graphene oxide nanocomposite ...
M. Hasheena, A. Ratnamala, M. Noorjahan, G. Deepthi Reddy, Gousia Begum   +4 more
doaj   +1 more source

Role of tyrosine M210 in the initial charge separation of reaction centers of Rhodobacter sphaeroides [PDF]

, 1990
Femtosecond spectroscopy was used in combination with site-directed mutagenesis to study the influence of tyrosine M210 (YM210) on the primary electron transfer in the reaction center of Rhodobacter sphaeroides.
Allen J. P., Becker M., Breton J., Bylina E. J., Bylina E. J., Chang C. H., Christoph Lauterwasser, Deisenhofer J., Dieter Oesterhelt, Farchaus J., Feher G., Gray K. A., Holzapfel W., Holzapfel W., Kevin A. Gray, Kirmaier C., Kirmaier C., Kirmaier C., Okamura Y., Parson W., Parson W. W., Rees D. C., Stilz H. U., Tiede D. M., Ulrich Finkele, Wolfgang Zinth   +25 more
core   +1 more source

Preoperative Tyrosine Levels as Predictive Biomarkers for Excessive Fat-Free Mass Loss Following Laparoscopic Sleeve Gastrectomy in Patients with Morbid Obesity

Metabolites
Background/Objectives: Fat-free mass (FFM) loss after metabolic and bariatric surgery (MBS) is associated with adverse long-term outcomes, including osteoporosis.
Inyoung Lee, Eunhye Seo, Yeongkeun Kwon, Chang Min Lee, Nam Hoon Kim, Jong-Han Kim, Sung Il Choi, Sungsoo Park   +7 more
doaj   +1 more source

High intensity interval training exercise increases dopamine D2 levels and modulates brain dopamine signaling

Frontiers in Public Health, 2023
BackgroundPrevious research has outlined the health benefits of exercise including its therapeutic potential for substance use disorders (SUD). These data have already been utilized and it is now common to find exercise as part of SUD treatment and ...
John Tyler, John Tyler, Madeline Podaras, Madeline Podaras, Brittany Richardson, Brittany Richardson, Nicole Roeder, Nicole Roeder, Nikki Hammond, John Hamilton, Kenneth Blum, Mark Gold, David A. Baron, Panayotis K. Thanos, Panayotis K. Thanos   +14 more
doaj   +1 more source

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility. [PDF]

, 2011
BackgroundCell migration plays an important role in many physiological and pathological processes, including immune cell chemotaxis and cancer metastasis.
Liao, Kan, Liu, Yang, Wang, Wenqi
core   +2 more sources

Structural basis of tubulin tyrosination by tubulin tyrosine ligase [PDF]

Journal of Cell Biology, 2013
Tubulin tyrosine ligase (TTL) catalyzes the post-translational retyrosination of detyrosinated α-tubulin. Despite the indispensable role of TTL in cell and organism development, its molecular mechanism of action is poorly understood. By solving crystal structures of TTL in complex with tubulin, we here demonstrate that TTL binds to the α and β subunits
Prota Andrea E., Magiera Maria M., Kuijpers Marijn, Bargsten Katja, Frey Daniel, Wieser Mara, Jaussi Rolf, Hoogenraad Casper C., Kammerer Richard A., Janke Carsten, Steinmetz Michel O.   +10 more
openaire   +3 more sources

Role of cytosolic, tyrosine‐insensitive prephenate dehydrogenase in Medicago truncatula

Plant Direct, 2020
l‐Tyrosine (Tyr) is an aromatic amino acid synthesized de novo in plants and microbes downstream of the shikimate pathway. In plants, Tyr and a Tyr pathway intermediate, 4‐hydroxyphenylpyruvate (HPP), are precursors to numerous specialized metabolites ...
Craig A. Schenck, Josh Westphal, Dhileepkumar Jayaraman, Kevin Garcia, Jiangqi Wen, Kirankumar S. Mysore, Jean‐Michel Ané, Lloyd W. Sumner, Hiroshi A. Maeda   +8 more
doaj   +1 more source