Results 221 to 230 of about 1,776,183 (353)

POSTER: ALL-022 Assessment of Molecular Response to Tyrosine Kinase Inhibitors in Tunisian Patients With Ph+ Acute Lymphoblastic Leukemia

, 2023
Rim Frikha, Amina El Aoud, Hassen Kamoun
openalex   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, EarlyView.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

Role of Tyrosine Kinase Inhibitors in Modulating Chondrocyte Activity and Cartilage Diseases. [PDF]

J Bone Metab
Hadid KA, Zaki MK, Alassaf FA, Abed MN.
europepmc   +1 more source

Coexisting with Clonal Evolution and BCR-ABL Mutant in CML Patients Treated with Second-generation Tyrosine Kinase Inhibitors Predict the Discrepancy of in vitro Drug Sensitivity [PDF]

, 2010
Jae‐Sook Ahn, Yeo-Kyeoung Kim, Se Ryeon Lee, Yu Li, Deok‐Hwan Yang, Sang‐Hee Cho, Hyun Jeong Shim, Woo Kyun Bae, Je‐Jung Lee, Ik-Joo Chung, Myung Gun Shin, Hyeoung-Joon Kim   +11 more
openalex   +1 more source

INCIDENCE AND ASSOCIATED CLINICAL FACTORS OF THYROID DYSFUNCTION DURING TYROSINE KINASE INHIBITOR THERAPY AMONG NONTHYROIDAL CANCER PATIENTS

, 2022
Nenuel Angelo Luna, Jennilyn Quinitio, Erick Erick, Sjoberg Kho, Priscilla B. Caguioa   +4 more
openalex   +2 more sources

Disruption of Gut Microbiota‐Mediated De Novo NAD+ Synthesis Contributes to the Development of Polycystic Ovary Syndrome

Advanced Science, EarlyView.
This study demonstrates that patients with PCOS exhibit altered gut microbial profiles, and FMT from PCOS patients induces PCOS‐like symptoms in mice. Specifically, gut dysbiosis reduces 3‐HAA levels in the context of PCOS. Administration of 3‐HAA to mice alleviates PCOS by promoting de novo NAD+ synthesis.
Ke Chen, Huafeng Geng, Yang Zheng, Hongyang Xie, Rui Qin, Junyang Chen, Cong Ye   +6 more
wiley   +1 more source

The Landscape of Genomic Alterations in Receptor Tyrosine Kinase Pathways in Biliary Cancers: Implications for Targeted Therapies. [PDF]

J Gastrointest Cancer
Voutsadakis IA.
europepmc   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, EarlyView.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Tyrosine kinase inhibitors in Ewing's sarcoma: a systematic review. [PDF]

BMC Cancer
Assi A, Farhat M, Mohanna R, Hachem MCR, Zalaquett Z, Aoun M, Farraj SA, Daher M, Sebaaly A, Kourie HR.   +9 more
europepmc   +1 more source

Schizosaccharomyces pombe Spk1 is a Tyrosine-Phosphorylated Protein Functionally Related to Xenopus Mitogen-Activated Protein Kinase

, 1993
Yukiko Gotoh, Eisuke Nishida, Mizuki Shimanuki, Takashi Toda, Yoshiyuki Imai, Masayuki Yamamoto   +5 more
openalex   +2 more sources