Results 281 to 290 of about 1,776,183 (353)

Repurposing the Tyrosine Kinase Inhibitors Targeting FGFR and VEGFR Pathways for Cancer Therapy: A Comprehensive Review. [PDF]

Cancers (Basel)
Boichuk S, Gessel T.
europepmc   +1 more source

A Transmembrane Protein WAI‐B2 Confers Multiple Disease Resistance in Wheat by Activating Autoimmunity

Advanced Science, EarlyView.
Wheat production is under threat from multiple diseases. This study clones the wheat autoimmunity gene WAI‐B2 from an EMS‐induced mutant that encodes a distinct transmembrane protein conferring resistance to wheat rusts and powdery mildew ‐ two major diseases affecting wheat crops.
Wenling Li, Yongxing Chen, Lei Dong, Guanghao Guo, Huaizhi Zhang, Tao Shen, Gaojie Wang, Lingli Dong, Ping Lu, Miaomiao Li, Dan Qiu, Keyu Zhu, Beibei Li, Yikun Hou, Xuejia Cui, Baoge Huang, Fugang Yang, Hongkui Fu, Delin Li, Zhan Li, Jinghuang Hu, Yunfeng Qu, Huanhuan Lou, Shisheng Chen, Zaifeng Li, Ling Kang, Wuyun Yang, Chengguo Yuan, Hongjie Li, Yusheng Zhao, Zhiyong Liu, Haiyan Jia, Qiuhong Wu   +32 more
wiley   +1 more source

Dose Optimization of Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia. [PDF]

Clin Pharmacol
Chen J, Zhu Y, Zhao Y, Guo N, Yao Y, Luo X, Huang L.   +6 more
europepmc   +1 more source

Punicalagin Enhances Autophagy Through Sirtuin 1/FoxO3a Axis to Inhibit Intracellular Mycobacterium Abscessus Infection

Advanced Science, EarlyView.
Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi, Bihan Xu, Dan Cao, Kaijin Xu, Ying Zhang   +4 more
wiley   +1 more source

Targeting Src tyrosine kinase to enhance radioiodide uptake in breast cancer. [PDF]

Endocr Relat Cancer
Poole VL, Alshahrani MM, Manivannan S, Landa I, Hariharan A, Thompson RJ, Kocbiyik M, Thornton CEM, Brookes K, Fletcher A, Boelaert K, Read ML, McCabe CJ, Smith VE.   +13 more
europepmc   +1 more source

RADT-41. THE ROLE OF RADIOTHERAPY IN RESECTED NON-SMALL CELL LUNG CANCER BRAIN METASTASES TREATED WITH CNS-ACTIVE TYROSINE KINASE INHIBITORS [PDF]

Abrar Choudhury, Florence Keane, Lin Zhu, Sarah Waliany, Ariel Marciscano, Justin Gainor, Zofia Piotrowska, Jessica Lin, Kevin Oh, Daniel Cahill, Priscilla Brastianos, Rifaquat Rahman, Shyam Tanguturi, Nayan Lamba, Daphne Haas-Kogan, Henning Willers, Helen Shih, Ayal Aizer, Melin Khandekar   +18 more
openalex   +1 more source

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Advanced Science, EarlyView.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Xu, Hongxi Wu   +8 more
wiley   +1 more source

Targeting MERTK tyrosine kinase: Virtual screening and molecular dynamics insights for anti-cancer drug development. [PDF]

PLoS One
Kifayat K, Singh K, Khan M, Razia DEM, Khan S, Dong C, Wang L.   +6 more
europepmc   +1 more source

Microglial Feimin Alleviates Cognitive Impairment in High‐Fat Diet‐Fed Mice

Advanced Science, EarlyView.
Microglial feimin deletion exacerbates lipotoxicity‐induced neuroinflammation and cognitive decline. In both in vitro and in vivo models, loss of feimin aggravated lipid droplet accumulation, IL‐1β/IL‐6 release, and neuronal injury through the PI3K–AKT–mTOR pathway, ultimately leading to severe neuronal apoptosis and cognitive impairment under high‐fat
Ran Gao, Zhonghua Xiong, Wenting Su, Jiahui Deng, Bin Zhai, Gaizhi Zhu, Min Zhang, Qi Zeng, Jinming Qiu, Ziqing Bian, He Xiao, Guoming Luan, Renxi Wang   +12 more
wiley   +1 more source

Combined cellular and biochemical profiling of Bruton's tyrosine kinase inhibitor nemtabrutinib reveals potential application in MAPK-driven cancers. [PDF]

Front Oncol
Kluitmans DJF, Melis JJTM, van den Bossche E, Ytsma J, de Roos JADM, van Linden OPJ, Grobben Y, Kooijman JJ, Zaman GJR.   +8 more
europepmc   +1 more source