Results 101 to 110 of about 8,536 (192)

Differential distribution of factors involved in pre-mRNA processing in the yeast cell nucleus [PDF]

, 1990
The yeast cell nucleus has previously been shown to be divided into two regions by a variety of microscopic approaches. We used antibodies specific for the 2,2,7-trimethylguanosine cap structure of small nuclear ribonucleic acids (snRNAs) and for a ...
Potashkin, J. A., Derby, R. J., Spector, D. L.   +2 more
core   +1 more source

A Novel tRF, HCETSR, Derived From tRNA‐Glu/TTC, Inhibits HCC Malignancy by Regulating the SPBTN1‐catenin Complex Axis

Advanced Science, Volume 12, Issue 13, April 3, 2025.
HCETSR, derived from tRNA‐Glu/TTC, binds to SPTBN1, promoting the dissociation of SPTBN1 from the catenin complex and facilitating the translocation of the catenin complex from the cell membrane to the nucleus. Meanwhile, HCETSR reduces proteasomal degradation of β‐catenin and synthesis of nascent β‐catenin.
Tao Rui, Kangbei Zhu, Zonglei Mao, Jiaping Wu, Yi Pan, Qianwei Ye, Cong Chen, Aizhai Xiang, Jufeng Guo, Ning Tang, Jing Zhang, Shusen Zheng, Jian Liu, Xiao Xu   +13 more
wiley   +1 more source

Evolution of alternative RNA-splicing [PDF]

, 2018
Pojava alternativnog prekrajanja nesumnjivo predstavlja iznimno važan korak u evoluciji eukariota. Iako nije poznato kada se točno pojavilo, zasigurno je od tada snažno povećalo kodirajući potencijal genoma.
Pavletić, Bruno
core   +2 more sources

In Vitro Studies of the Prp9·Prp11·Prp21 Complex Indicate a Pathway for U2 Small Nuclear Ribonucleoprotein Activation [PDF]

, 1996
Pre-mRNA splicing takes place on a large ribonucleoprotein particle, the spliceosome which contains the five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6. In Saccharomyces cerevisiae the mRNA splicing factors, Prp9, Prp11, and Prp21,
Abelson, John, O'Day, Christine L., Wiest, Debra K.   +2 more
core   +1 more source

Alternative splicing regulation by tumor suppressing subtransferable candidate 4: a pathway to tumor suppression

Frontiers in Immunology
IntroductionRNA splicing is a crucial posttranscriptional process that governs gene expression, and defects in alternative splicing contribute to various diseases, including cancer.
Haiping Zhao, Nana Wu, Gaigai Wei, Huiling Zhang, Tingrong Ren, Jingjing Yi, Yuqi Zhang, Zixi Wang, Yihan Wang, Zhihan Guo, Duanwu Zhang   +10 more
doaj   +1 more source

Mud2 functions in transcription by recruiting the Prp19 and TREX complexes to transcribed genes [PDF]

, 2007
The different steps of gene expression are intimately linked to coordinate and regulate this complex process. During transcription, numerous RNA-binding proteins are already loaded onto the nascent mRNA and package the mRNA into a messenger ...
Andersen, Ulrik L., Corney, Joel F., Dong, Rui-Fang, Drummond, P. D., Elser, Dominique, Heersink, Joel, Huck, Alexander, Leuchs, G., Milanovic, Josip   +8 more
core   +1 more source

SmD3 regulates intronic noncoding RNA biogenesis [PDF]

, 2012
Accumulation of excess lipid in nonadipose tissues is associated with oxidative stress and organ dysfunction and plays an important role in diabetic complications.
Michel, Carlos I, Ory, Daniel S, Schaffer, Jean E, Scruggs, Benjamin S   +3 more
core   +2 more sources

Nuclear Condensates of WW Domain‐Containing Adaptor With Coiled‐Coil Regulate Mitophagy via Alternative Splicing

Advanced Science
Biomolecular condensates segregate nuclei into discrete regions, facilitating the execution of distinct biological functions. Here, it is identified that the WW domain containing adaptor with coiled‐coil (WAC) is localized to nuclear speckles via its WW ...
Jiahe Wang, Yi Fan, Guowen Luo, Liang Xiong, Lijie Wang, Zhuoxuan Wu, Jiayi Wang, Zhengying Peng, Clifford J Rosen, Kefeng Lu, Junjun Jing, Quan Yuan, Zhenwei Zhang, Chenchen Zhou   +13 more
doaj   +1 more source

Common lines modeling for reference free ab-initio reconstruction in cryo-EM

, 2017
We consider the problem of estimating an unbiased and reference-free ab-inito model for non-symmetric molecules from images generated by single-particle cryo-electron microscopy.
Greenberg, Ido, Shkolnisky, Yoel
core   +1 more source

Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells [PDF]

, 1990
SF2, an activity necessary for 5' splice site cleavage and lariat formation during pre-mRNA splicing in vitro, has been purified to near homogeneity from HeLa cells. The purest fraction contains only two related polypeptides of 33 kD.
Conway, G. C., Kozak, D., Krainer, A. R.   +2 more
core   +1 more source