Results 11 to 20 of about 15,914 (183)

EXPRESSION OF UBIQUITIN SPECIFIC PEPTIDASE GENES IN IRE1 KNOCKDOWN U87 GLIOMA CELLS UPON GLUCOSE DEPRIVATION [PDF]

Biotechnologia Acta, 2016
We have studied the effect of glucose deprivation on the expression of genes encoding for ubiquitin specific peptidases — USP and autophagy related 7 ATG7 in U87 glioma cells in relation to inhibition of inositol requiring enzyme-1 (IRE1).
O. H. Minchenko, O. O. Riabovol, O. V. Halkin, S. V. Danilovskyi, D. O. Minchenko, O. O. Ratushna   +5 more
doaj   +4 more sources

Integrative Single-Cell Analysis Reveals Targetable Vacuole Membrane Protein 1-Mediated Mechanism of Tumor Angiogenesis in Glioblastoma. [PDF]

MedComm (2020)
VMP1 promotes angiogenesis in glioblastoma (GBM) through VEGFA‐VEGFR2 signaling and activation of endothelial cells. The FDA‐approved anti‐VEGFA antibody, bevacizumab (BEV), can counteract VMP1's tumor‐promoting effect in GBM. Targeting VMP1 or its associated pathways could be a new therapeutic strategy, either alone or in combination with BEV.
Jin L, Chen B, Liao J, Guo W, Zhu Z, Ali S, Leung GK, Wang P, Kiang KM.   +8 more
europepmc   +2 more sources

lncRNAs combine and crosstalk with NSPc1 in ATRA-induced differentiation of U87 glioma cells. [PDF]

Oncol Lett, 2019
Nervous system polycomb 1 (NSPc1) is a member of the polycomb group (PcG) family of proteins and has been demonstrated to maintain the differentiation and pluripotency of stem cells. Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in the control of pluripotency and differentiation in embryonic and pluripotent cells.
Liang Z, Wang Y, Li H, Sun Y, Gong Y.
europepmc   +4 more sources

Resveratrol represses YKL-40 expression in human glioma U87 cells [PDF]

BMC Cancer, 2010
Abstract Background Glioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-expressed genes in these tumours but not in normal brain tissue.
Kawai Nobuyuki, Miyake Keisuke, Okada Masaki, Diah Suwarni, Matsumoto Kensuke, Zhang Xiang, Murao Koji, Zhang Wei, Fei Zhou, Tamiya Takashi   +9 more
openaire   +3 more sources

Proapoptotic effect of Ginkgo biloba extract on U87 glioma cells

The FASEB Journal, 2021
Objective To study the pro‐apoptotic effect of Ginkgo biloba extract on U87 glioma cells. Methods After 24 hours of Ginkgo biloba extract intervention, the proliferation of U87 glioma cells was observed by CCK‐8 with different ...
Chunyan Hao, Hubin Duan, Xiaohong Qiao, Juan Zheng, Wen Xue   +4 more
openaire   +1 more source

Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells

BMC Cancer, 2018
Background Temozolomide (TMZ)-induced side effects and drug tolerance to human gliomas are still challenging issues now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houpo), is safe for normal brain ...
Chung-Ching Chio, Kung-Yen Chen, Cheng-Kuei Chang, Jian-Ying Chuang, Chih-Chung Liu, Shing-Hwa Liu, Ruei-Ming Chen   +6 more
doaj   +1 more source

MicroRNA-34a Suppresses Cell Proliferation and Induces Apoptosis in U87 Glioma Stem Cells [PDF]

Technology in Cancer Research & Treatment, 2012
Tumor stem cells (TSCs) have been identified in many malignant tumors and are unique in their self-renewal, multi-differentiation and tumor growth maintenance capabilities. MicroRNAs (miRNAs) are small endogenous, non-coding RNAs that predominately modulate target gene expression at the post-transcriptional level.
Lihua, Sun, Zhifeng, Wu, Yun, Shao, Yi, Pu, Weifeng, Miu, Jianshe, Yao, Yiping, Wu, Zhengxiang, Yang   +7 more
openaire   +2 more sources

LncRNA‐H19 gene plays a significant role in regulating glioma cell function

Molecular Genetics & Genomic Medicine, 2021
Background Glioma is an aggressive adult primary cancer, and is characterized by low cure rate, poor prognosis, and high recurrence. The present study aimed to investigate the effect of lncRNA‐H19 gene silencing on glioma cell function.
Ping Liu, Xinqiong Huang, Haijun Wu, Guoling Yin, Liangfang Shen   +4 more
doaj   +1 more source

Metabolic Impact of Anti-Angiogenic Agents on U87 Glioma Cells

PLoS ONE, 2014
Glioma cells not only secrete high levels of vascular endothelial growth factor (VEGF) but also express VEGF receptors (VEGFR), supporting the existence of an autocrine loop. The direct impact on glioma cells metabolism of drugs targeting the VEGF pathway, such as Bevacizumab (Bev) or VEGFR Tyrosine Kinase Inhibitor (TKI), is poorly known.U87 cells ...
Mesti, Tanja, Savarin, Philippe, Triba, Mohamed, Le Moyec, Laurence, Ocvirk, Janja, Banissi, Claire, Carpentier, Antoine   +6 more
openaire   +6 more sources

Indirubin exerts anticancer effects on human glioma cells by inducing apoptosis and autophagy

AMB Express, 2020
Glioma causes significant mortality across the world and the most aggressive type of brain cancer. The incidence of glioma is believed to increase in the next few decades and hence more efficient treatment strategies need to be developed for management ...
Zhaohui Li, Han Wang, Jun Wei, Liang Han, Zhigang Guo   +4 more
doaj   +1 more source