Results 11 to 20 of about 46,005 (150)

Selenium reduction of ubiquinone via SQOR suppresses ferroptosis

bioRxiv, 2023
Lee, Park et al. show that selenium has the ability to directly regulate the redox state of ubiquinone by donating electrons from hydrogen selenide via sulfide quinone oxidoreductase, thus preventing lipid peroxidation.
Namgyu Lee, Sung Jin Park, M. Lange, T. Tseyang, M. Doshi, Tae Yong Kim, Yoseb Song, Dong In Kim, P. Greer, James A. Olzmann, J. Spinelli, Dohoon Kim   +11 more
semanticscholar   +1 more source

Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy

Nature Communications, 2022
Mitochondrial complex I is a central metabolic enzyme that uses the reducing potential of NADH to reduce ubiquinone-10 (Q10) and drive four protons across the inner mitochondrial membrane, powering oxidative phosphorylation.
Injae Chung, John J. Wright, H. R. Bridges, Bozhidar S. Ivanov, Olivier Biner, Caroline S. Pereira, G. M. Arantes, J. Hirst   +7 more
semanticscholar   +1 more source

Mevalonate pathway provides ubiquinone to maintain pyrimidine synthesis and survival in p53-deficient cancer cells exposed to metabolic stress.

Cancer Research, 2019
Oncogene activation and loss of tumor suppressor function changes the metabolic activity of cancer cells to drive unrestricted proliferation. Moreover, cancer cells adapt their metabolism to sustain growth and survival when access to oxygen and nutrients
Irem Kaymak, C. R. Maier, W. Schmitz, A. Campbell, Beatrice Dankworth, C. Ade, S. Walz, M. Paauwe, C. Kalogirou, H. Marouf, M. Rosenfeldt, D. Gay, G. McGregor, O. Sansom, A. Schulze   +14 more
semanticscholar   +1 more source

Ubiquinone Biosynthesis over the Entire O2 Range: Characterization of a Conserved O2-Independent Pathway

mBio, 2019
In order to colonize environments with large O2 gradients or fluctuating O2 levels, bacteria have developed metabolic responses that remain incompletely understood.
L. Pelosi, Chau-Duy-Tam Vo, S. Abby, L. Loiseau, Bérengère Rascalou, M. Hajj Chehade, Bruno Faivre, Mathieu Goussé, Clothilde Chenal, N. Touati, L. Binet, David Cornu, C. Fyfe, M. Fontecave, F. Barras, M. Lombard, F. Pierrel   +16 more
semanticscholar   +1 more source

Chronic hypoxia–induced Cirbp hypermethylation attenuates hypothermic cardioprotection via down-regulation of ubiquinone biosynthesis

Science Translational Medicine, 2019
Chronic hypoxia–induced hypermethylation attenuates hypothermic cardioprotective effects of Cirbp and ubiquinone biosynthesis in rats and patients.
Yiwei Liu, Junyue Xing, Yongnan Li, Q. Luo, Z. Su, Xiaoling Zhang, Hao Zhang   +6 more
semanticscholar   +1 more source

Locking loop movement in the ubiquinone pocket of complex I disengages the proton pumps

Nature Communications, 2018
Complex I (proton-pumping NADH:ubiquinone oxidoreductase) is the largest enzyme of the mitochondrial respiratory chain and a significant source of reactive oxygen species (ROS).
Alfredo Cabrera-Orefice, E. G. Yoga, C. Wirth, K. Siegmund, K. Zwicker, S. Guerrero-Castillo, V. Zickermann, C. Hunte, U. Brandt   +8 more
semanticscholar   +1 more source

Structure-Based Discovery of Potential Fungicides as Succinate Ubiquinone Oxidoreductase Inhibitors.

Journal of Agricultural and Food Chemistry, 2017
A series of diphenyl ether-containing pyrazole-carboxamide derivatives was designed and synthesized as new succinate ubiquinone oxidoreductase (SQR) inhibitors. This highly potent molecular scaffold was developed from a moderately activie hit 3, obtained
Li Xiong, Hua Li, Lina Jiang, Jingming Ge, Wenchao Yang, X. Zhu, Guangfu Yang   +6 more
semanticscholar   +1 more source

Plastoquinone and Ubiquinone in Plants: Biosynthesis, Physiological Function and Metabolic Engineering

Frontiers in Plant Science, 2016
Plastoquinone (PQ) and ubiquinone (UQ) are two important prenylquinones, functioning as electron transporters in the electron transport chain of oxygenic photosynthesis and the aerobic respiratory chain, respectively, and play indispensable roles in ...
Miaomiao Liu, Shanfa Lu
semanticscholar   +1 more source

The Peroxidative Cleavage of Kaempferol Contributes to the Biosynthesis of the Benzenoid Moiety of Ubiquinone in Plants[OPEN]

The Plant Cell, 2018
Genetic and biochemical evidence shows that Arabidopsis and tomato can derive the ubiquinone precursor 4-hydroxybenzoate from the B-ring of kaempferol.
Eric Soubeyrand, T. Johnson, Scott Latimer, A. Block, Jeongim Kim, T. Colquhoun, E. Butelli, Cathie Martin, M. Wilson, G. Basset   +9 more
semanticscholar   +1 more source

The Ubiquinone-Ubiquinol Redox Cycle and Its Clinical Consequences: An Overview

International Journal of Molecular Sciences
Coenzyme Q10 (CoQ10) plays a key role in many aspects of cellular metabolism. For CoQ10 to function normally, continual interconversion between its oxidised (ubiquinone) and reduced (ubiquinol) forms is required.
David Mantle, Mollie Dewsbury, Iain P Hargreaves   +2 more
semanticscholar   +1 more source