Results 21 to 30 of about 46,005 (150)

Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors

Scientific Reports, 2018
Yeast Ndi1 is a monotopic alternative NADH dehydrogenase. Its crystal structure in complex with the electron acceptor, ubiquinone, has been determined. However, there has been controversy regarding the ubiquinone binding site. To address these points, we
T. Yamashita, D. Inaoka, T. Shiba, T. Oohashi, S. Iwata, T. Yagi, H. Kosaka, H. Miyoshi, S. Harada, K. Kita, K. Hirano   +10 more
semanticscholar   +1 more source

Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency

Journal of Cell Biology, 2017
PINK1 is mutated in Parkinson’s disease (PD), and mutations cause mitochondrial defects that include inefficient electron transport between complex I and ubiquinone.
M. Vos, Ann Geens, Claudia Böhm, Liesbeth Deaulmerie, J. Swerts, Matteo Rossi, K. Craessaerts, E. P. Leites, Philip Seibler, A. Rakovic, T. Lohnau, B. de Strooper, S. Fendt, V. Morais, C. Klein, P. Verstreken   +15 more
semanticscholar   +1 more source

The mitochondrial outer membrane protein mitoNEET is a redox enzyme catalyzing electron transfer from FMNH2 to oxygen or ubiquinone

Journal of Biological Chemistry, 2017
Increasing evidence suggests that mitoNEET, a target of the type II diabetes drug pioglitazone, is a key regulator of energy metabolism in mitochondria. MitoNEET is anchored to the mitochondrial outer membrane via its N-terminal α helix domain and hosts ...
Yiming Wang, A. P. Landry, H. Ding
semanticscholar   +1 more source

Redox potentials of ubiquinone, menaquinone, phylloquinone, and plastoquinone in aqueous solution

Photosynthesis Research, 2017
Quinones serve as redox active cofactors in bacterial photosynthetic reaction centers: photosystem I, photosystem II, cytochrome bc1, and cytochrome b6f. In particular, ubiquinone is ubiquitous in animals and most bacteria and plays a key role in several
Shinnosuke Kishi, Keisuke Saito, Yuki Kato, Hiroshi Ishikita   +3 more
semanticscholar   +1 more source

UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis

Nature, 2015
Ubiquinone (also known as coenzyme Q) is a ubiquitous lipid-soluble redox cofactor that is an essential component of electron transfer chains. Eleven genes have been implicated in bacterial ubiquinone biosynthesis, including ubiX and ubiD, which are ...
M. White, K. Payne, K. Fisher, S. Marshall, David Parker, N. Rattray, D. Trivedi, R. Goodacre, S. Rigby, N. Scrutton, Sam Hay, D. Leys   +11 more
semanticscholar   +1 more source

A genome-wide screen in Escherichia coli reveals that ubiquinone is a key antioxidant for metabolism of long-chain fatty acids

Journal of Biological Chemistry, 2017
Long-chain fatty acids (LCFAs) are used as a rich source of metabolic energy by several bacteria including important pathogens. Because LCFAs also induce oxidative stress, which may be detrimental to bacterial growth, it is imperative to understand the ...
Shashank Agrawal, K. Jaswal, A. Shiver, Himanshi Balecha, Tapas Patra, Rachna Chaba   +5 more
semanticscholar   +1 more source

Identification of the binding sites for ubiquinone and inhibitors in the Na+-pumping NADH-ubiquinone oxidoreductase from Vibrio cholerae by photoaffinity labeling

Journal of Biological Chemistry, 2017
The Na+-pumping NADH-quinone oxidoreductase (Na+-NQR) is the first enzyme of the respiratory chain and the main ion transporter in many marine and pathogenic bacteria, including Vibrio cholerae. The V.
Takeshi Ito, M. Murai, Satoshi Ninokura, Y. Kitazumi, Katherine G. Mezic, Brady F. Cress, M. Koffas, J. Morgan, B. Barquera, H. Miyoshi   +9 more
semanticscholar   +1 more source

Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis

Nature Communications, 2015
Ubiquinone (UQ) is implicated in mitochondrial electron transport, superoxide generation and as a membrane antioxidant. Here we present a mouse model in which UQ biosynthesis can be interrupted and partially restored at will.
Ying Wang, Daniella Oxer, S. Hekimi
semanticscholar   +1 more source

The antioxidant effect of ubiquinone and combined therapy on mitochondrial function in blood cells in non-proliferative diabetic retinopathy: A randomized, double-blind, phase IIa, placebo-controlled study

Redox Report, 2016
Objectives: To evaluate the effect of ubiquinone and combined antioxidant therapy on mitochondrial function in non-proliferative diabetic retinopathy (NPDR) in a randomized, double-blind, phase IIa, placebo-controlled, clinical trial.
A. D. Rodríguez-Carrizalez, J. A. Castellanos-González, Esaú César Martínez-Romero, Guillermo Miller-Arrevillaga, L. M. Román-Pintos, F. Pacheco-Moisés, A. Miranda-Díaz   +6 more
semanticscholar   +1 more source

CORRIGENDUM: Ubiquinone-quantum dot bioconjugates for in vitro and intracellular complex I sensing

Scientific Reports, 2013
Quantum dots (QDs) have attracted increasing interest in bioimaging and sensing. Here, we report a biosensor of complex I using ubiquinone-terminated disulphides with different alkyl spacers (QnNS, n = 2, 5 and 10) as surface-capping ligands to ...
Wei Ma, Li-Xia Qin, Feng-tao Liu, Zhen Gu, Jian Wang, Z. Pan, T. James, Yitao Long   +7 more
semanticscholar   +1 more source