Results 21 to 30 of about 18,290,537 (258)

Proteasome-associated ubiquitin ligase relays target plant hormone-specific transcriptional activators [PDF]

, 2022
The ubiquitin-proteasome system is vital to hormone-mediated developmental and stress responses in plants. Ubiquitin ligases target hormone-specific transcriptional activators (TAs) for degradation, but how TAs are processed by proteasomes remains ...
Grey, Heather, Spoel, Steven H., Mori, Izumi, Wang, Zhishuo, Genschik, Pascal, Nomoto, Mika, Potuschak, Thomas, Mori, Izumi C., Spoel, Steven, Orosa-Puente, Beatriz, Matsuura, Takakazu, Tada, Yasuomi   +11 more
core   +1 more source

Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation [PDF]

, 2012
Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc, Marfany Gemma, Denuc Isern, Amanda, Burr, A. A., Gemma Marfany, Blount Jessica R., Sokol V Todi, Todi Sokol V., Marfany i Nadal, Gemma, Jessica R Blount, Denuc Amanda, Blount, J. R., Aaron A Burr, Burr Aaron A., Todi, Sokol V.   +14 more
core   +2 more sources

Proteasome inhibition-enhanced fracture repair is associated with increased mesenchymal progenitor cells in mice.

PLoS ONE, 2022
The ubiquitin/proteasome system controls the stability of Runx2 and JunB, proteins essential for differentiation of mesenchymal progenitor/stem cells (MPCs) to osteoblasts.
Hengwei Zhang, Xing Li, Jiatong Liu, Xi Lin, Lingpeng Pei, Brendan F Boyce, Lianping Xing   +6 more
doaj   +2 more sources

The Proteasome-Ubiquitin System Is Required for Efficient Killing of Intracellular Streptococcus pneumoniae by Brain Endothelial Cells

mBio, 2014
Streptococcus pneumoniae (pneumococcus) is a Gram-positive bacterium that causes serious invasive diseases, such as pneumonia, bacteremia, and meningitis, with high morbidity and mortality throughout the world.
Federico Iovino, Henrik Gradstedt, Jetta J. Bijlsma   +2 more
doaj   +1 more source

Niclosamide prevents the formation of large ubiquitin-containing aggregates caused by proteasome inhibition. [PDF]

PLoS ONE, 2010
Protein aggregation is a hallmark of many neurodegenerative diseases and has been linked to the failure to degrade misfolded and damaged proteins. In the cell, aberrant proteins are degraded by the ubiquitin proteasome system that mainly targets short ...
Esther Gies, Inga Wilde, Jason M Winget, Maria Brack, Barak Rotblat, Carolina Arias Novoa, Aruna D Balgi, Poul H Sorensen, Michel Roberge, Thibault Mayor   +9 more
doaj   +1 more source

Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]

, 2014
Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core   +1 more source

Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the pap1 transcription factor [PDF]

, 2012
Here we report the result of a genetic screen for mutants resistant to the microtubule poison methyl benzimidazol-2-yl carbamate (MBC) that were also temperature sensitive for growth.
Caroline R. Wilkinson (117644), Itaru Samejima, Mathiassen, Søs G, Penney, M., Mary Penney (117638), McInerny Christopher J., Samejima, I., Mairi Wallace (117659), Wallace Mairi, Søs G Mathiassen, Gordon Colin, Gordon, C., Wallace, Mairi, Christopher J. McInerny (117648), Hartmann-Petersen, Rasmus, Christopher J McInerny, McInerny, C.J., McInerny, Christopher J, Mary Penney, Takashi Toda (102488), Rasmus Hartmann-Petersen (117664), Toda, Takashi, Wilkinson, Caroline, Toda, T., Mathiassen Søs G., Penney, Mary, Colin Gordon, Penney Mary, Hartmann-Petersen, R., Itaru Samejima (117642), Wilkinson, C.R., Colin Gordon (117667), Hartmann-Petersen Rasmus, Søs G. Mathiassen (117654), Samejima Itaru, Wilkinson Caroline R., Mathiassen, Søs, Wilkinson, Caroline R, Rasmus Hartmann-Petersen, McInerny, Christopher, Toda Takashi, Wallace, M., Samejima, Itaru, Gordon, Colin, Takashi Toda, Mathiassen, S.G., Caroline R Wilkinson, Mairi Wallace   +47 more
core   +2 more sources

Ubiquitin, ubiquitination and the ubiquitin-proteasome system in cancer [PDF]

, 2010
Deep insight on Ubiquitin, ubiquitination and the ubiquitin-proteasome system in ...
Voutsadakis, IA, IA Voutsadakis
core   +1 more source

Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]

, 2000
This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia, Lane, David P., T. Hay, Ronald, Hay, Ronald Thomas, Rodriguez, Manuel S, Desterro, Joana M P   +6 more
core   +1 more source

The molecular basis of CRL4 ubiquitin ligase architecture, targeting and regulation [PDF]

, 2013
Members of the CUL4-RBX1-DDB1 (CRL4) E3 ubiquitin ligase family regulate multiple cellular processes including development, transcription, and DNA repair.
Fischer, Eric Sebastian
core   +1 more source