Results 71 to 80 of about 91,428 (363)

Sequence of a Cloned Tomato Ubiquitin Conjugating Enzyme

Plant Physiology, 1993
Ubiquitin is a small, abundant protein that is seemingly present in a11 eukaryotic cells and that is covalently ligated to specific protein substrates via an ATP-dependent reaction. This ubiquitinous has been demonstrated to target proteins for subsequent cellular degradation.
Sarah Louise Barton, Julie E. Gray, Alexandra Louise Lowe, Steve Picton, Donald Grierson   +4 more
openaire   +4 more sources

SUMO chain-induced dimerization activates RNF4 [PDF]

, 2014
Dimeric RING E3 ligases interact with protein substrates and conformationally restrain the ubiquitin-E2-conjugating enzyme thioester complex such that it is primed for catalysis.
Alejandro Rojas-Fernandez, Anna Plechanovová, Brzovic, Buchwald, Budhidarmo, Calderon-Villalobos, de Bie, Deshaies, Desterro, Desterro, Dou, Dou, Dueber, Ellis Jaffray, Feltham, Galanty, Geiss-Friedlander, Geoffroy, Geoffroy, Goddard, Goddard, Golebiowski, Guzzo, Haas, Hattersley, Hay, Hecker, Hickey, Johnson, Kang, Kravtsova-Ivantsiv, Lallemand-Breitenbach, Liew, Linke, Mace, Martin, Melchior, Michael H. Tatham, Mu, Mukhopadhyay, Mukhopadhyay, Neil Hattersley, Perry, Plechanovová, Plechanovová, Pruneda, Rodriguez, Ronald T. Hay, Saitoh, Sampson, Scheffner, Schermelleh, Shen, Song, Spencer, Sun, Tatham, Tatham, Tatham, Tatham, Vyas, Wenzel, Yin, Yin, Zhang   +64 more
core   +2 more sources

Ubiquitin-conjugating enzyme E2T (UBE2T) and denticleless protein homolog (DTL) are linked to poor outcome in breast and lung cancers

Scientific Reports, 2017
Protein ubiquitination and degradation represent druggable vulnerabilities of cancer cells. We used gene expression and functional annotation analyses to identify genes in the ubiquitin pathway which are differentially expressed between normal breast and
Javier Pérez-Peña, V. Corrales-Sánchez, E. Amir, A. Pandiella, A. Ocaña   +4 more
semanticscholar   +1 more source

Structure of the Human FANCL RING-Ube2T Complex Reveals Determinants of Cognate E3-E2 Selection [PDF]

, 2014
The combination of an E2 ubiquitin-conjugating enzyme with an E3 ubiquitin-ligase is essential for ubiquitin modification of a substrate. Moreover, the pairing dictates both the substrate choice and the modification type. The molecular details of generic
Hodson, Charlotte, Miles, Jennifer Anne, Purkiss, Andrew, Walden, Helen   +3 more
core   +3 more sources

Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I

Journal of Biological Chemistry, 2018
March-I is a membrane-bound E3 ubiquitin ligase belonging to the membrane-associated RING-CH (March) family. March-I ubiquitinates and down-regulates the expression of major histocompatibility complex (MHC) class II and cluster of differentiation 86 ...
Lei Lei, Joanna Bandola-Simon, P. Roche
semanticscholar   +1 more source

The Emerging Role and Mechanism of E2/E3 Hybrid Enzyme UBE2O in Human Diseases

Biomedicines
The ubiquitin–proteasome system (UPS) plays a pivotal role in determining protein fate, regulating signal transduction, and maintaining cellular homeostasis. Protein ubiquitination, a key post-translational modification, is orchestrated by the sequential
Qian Cheng, Zuyin Li, Yongjian Li, Lei Chen, Dingbao Chen, Jiye Zhu   +5 more
doaj   +1 more source

Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer’s Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7)

Genes, 2016
Our understanding of the highly specialized functions for small non-coding single-stranded RNA (ssRNA) in the transcriptome of the human central nervous system (CNS) continues to evolve.
Yuhai Zhao, P. Alexandrov, V. Jaber, W. Lukiw   +3 more
semanticscholar   +1 more source

SUMO modification of the ubiquitin-conjugating enzyme E2-25K

Nature Structural & Molecular Biology, 2005
Post-translational modification with small ubiquitin-related modifier (SUMO) alters the function of many proteins, but the molecular mechanisms and consequences of this modification are still poorly defined. During a screen for novel SUMO1 targets, we identified the ubiquitin-conjugating enzyme E2-25K (Hip2).
Edith Oberhofer, Puck Knipscheer, Frauke Melchior, Frauke Melchior, Stefan Jentsch, Roman Körner, Titia K. Sixma, Jesper V. Olsen, A. Pichler, A. Pichler, Willem J. van Dijk   +10 more
openaire   +5 more sources

Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1 to S phase transition and identifies a conserved family of proteins [PDF]

, 1996
Regulation of cell cycle progression occurs in part through the targeted degradation of both activating and inhibitory subunits of the cyclin-dependent kinases. During G1, CDC4, encoding a WD-40 repeat protein, and CDC34, encoding a ubiquitin-conjugating
Adams, Alison E M, Byers, Breck, Goebl, Mark G, Goetsch, Loretta, Johnson, Stephen L, Mathias, Neal, Pringle, John R, Winey, Mark   +7 more
core   +3 more sources

Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening

Journal of Medicinal Chemistry, 2017
Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpressed in several cancers, representing an attractive target for the development of inhibitors.
F. Morreale, A. Bortoluzzi, V. Chaugule, C. Arkinson, H. Walden, A. Ciulli   +5 more
semanticscholar   +1 more source