Ubiquitin-Conjugating Enzymes in Cancer [PDF]
Cells, 2021 The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The
Quyen Thu Bui +4 more
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The UBE2D ubiquitin conjugating enzymes: Potential regulatory hubs in development, disease and evolution [PDF]
Frontiers in Cell and Developmental Biology, 2022 Ubiquitination of cellular proteins plays critical roles in key signalling pathways and in the regulation of protein turnover in eukaryotic cells. E2 ubiquitin conjugating enzymes function as essential intermediates in ubiquitination reactions by acting ...
Monica Roman-Trufero, Niall Dillon
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Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes [PDF]
Communications BiologyProteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a ‘biological Proteolysis ...
Jonathan D. Taylor +16 more
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Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes [PDF]
Nature Communications, 2023 UBA1 is the primary E1 ubiquitin-activating enzyme responsible for generation of activated ubiquitin required for ubiquitination, a process that regulates stability and function of numerous proteins.
Wenjing Yan +17 more
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Genome-wide identification and expression analysis of E2 ubiquitin-conjugating enzymes in tomato [PDF]
Scientific Reports, 2017 The ubiquitin-proteasomal degradation mechanism has gained the attention over the past decade. The E2 ubiquitin conjugating enzymes are the crucial part of ubiquitination mechanism and they are believed to hold imperative association for plant ...
Bhaskar Sharma, Tarun Kumar Bhatt
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Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium. [PDF]
PLoS PathogensThe ubiquitin-proteasome system (UPS) is essential for Plasmodium falciparum survival and represents a potential target for antimalarial therapies. We utilised a ubiquitin- activity based probe (Ub-Dha) to capture active components of the ubiquitin ...
Cameron Smith +6 more
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Mechanism and Disease Association With a Ubiquitin Conjugating E2 Enzyme: UBE2L3 [PDF]
Frontiers in Immunology, 2022 Ubiquitin conjugating enzyme E2 is an important component of the post-translational protein ubiquitination pathway, which mediates the transfer of activated ubiquitin to substrate proteins.
Xiaoxia Zhang +7 more
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Echinococcus granulosus ubiquitin-conjugating enzymes (E2D2 and E2N) promote the formation of liver fibrosis in TGFβ1-induced LX-2 cells [PDF]
Parasites & VectorsBackground Cystic echinococcosis (CE) is a widespread zoonosis caused by the infection with Echinococcus granulosus sensu lato (E. granulosus s.l.). CE cysts mainly develop in the liver of intermediate hosts, characterized by the fibrotic tissue that ...
Xiaodi Du +6 more
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Targeting neddylation E2s: a novel therapeutic strategy in cancer
Journal of Hematology & Oncology, 2021 Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F (UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part in posttranslational modification and change the activity of target proteins.
Yi-Chao Zheng +6 more
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Robust high-throughput assays to assess discrete steps in ubiquitination and related cascades
BMC Molecular and Cell Biology, 2020 Background Ubiquitination and ubiquitin-like protein post-translational modifications play an enormous number of roles in cellular processes. These modifications are constituted of multistep reaction cascades.
Gabriel Fenteany +5 more
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