Ubiquitin-Conjugating Enzymes in Cancer [PDF]
Cells, 2021 The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The
Quyen Thu Bui +4 more
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The UBE2D ubiquitin conjugating enzymes: Potential regulatory hubs in development, disease and evolution [PDF]
Frontiers in Cell and Developmental Biology, 2022 Ubiquitination of cellular proteins plays critical roles in key signalling pathways and in the regulation of protein turnover in eukaryotic cells. E2 ubiquitin conjugating enzymes function as essential intermediates in ubiquitination reactions by acting ...
Monica Roman-Trufero, Niall Dillon
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Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes [PDF]
Communications BiologyProteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a ‘biological Proteolysis ...
Jonathan D. Taylor +16 more
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Genome-wide identification and expression analysis of E2 ubiquitin-conjugating enzymes in tomato [PDF]
Scientific Reports, 2017 The ubiquitin-proteasomal degradation mechanism has gained the attention over the past decade. The E2 ubiquitin conjugating enzymes are the crucial part of ubiquitination mechanism and they are believed to hold imperative association for plant ...
Bhaskar Sharma, Tarun Kumar Bhatt
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A novel missense variant at the site of interaction between RLIM and E2 ubiquitin-conjugating enzymes causes Tønne-Kalscheuer syndrome [PDF]
BMC PediatricsHemizygous variants in the RLIM gene, which is located on chromosome Xq13, cause Tønne-Kalscheuer syndrome (TOKAS). This X-linked recessive disorder is characterized by intellectual disability (ID), global developmental delay, behavioral impairment, gait
Evelina Siavrienė +5 more
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Echinococcus granulosus ubiquitin-conjugating enzymes (E2D2 and E2N) promote the formation of liver fibrosis in TGFβ1-induced LX-2 cells [PDF]
Parasites & VectorsBackground Cystic echinococcosis (CE) is a widespread zoonosis caused by the infection with Echinococcus granulosus sensu lato (E. granulosus s.l.). CE cysts mainly develop in the liver of intermediate hosts, characterized by the fibrotic tissue that ...
Xiaodi Du +6 more
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The Journal of Clinical InvestigationAltered protein homeostasis through proteasomal degradation of ubiquitinated proteins is a hallmark of many cancers. Ubiquitination, coordinated by E1, E2, and E3 enzymes, involves up to 40 E2-conjugating enzymes in humans to specify substrates and ...
Chiharu Ishikawa +12 more
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E2 superfamily of ubiquitin-conjugating enzymes: constitutively active or activated through phosphorylation in the catalytic cleft. [PDF]
Sci Rep, 2015 Valimberti I +4 more
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Endoplasmic reticulum and inner nuclear membrane ubiquitin-conjugating enzymes Ubc6 and Ubc7 confer resistance to hygromycin B in Saccharomyces cerevisiae. [PDF]
MicroPubl BiolOwutey SL +10 more
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Data in Brief, 2022 The Ubiquitin-Proteasome System (UPS) regulates many cellular processes in eukaryotic cells. Ubiquitylation by the UPS mainly directs proteins to proteasomal degradation, but it can also have non-degradative functions, such as regulating protein activity
Valentina Rossio, Joao A Paulo
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