Results 11 to 20 of about 63,885 (332)

The UBE2D ubiquitin conjugating enzymes: Potential regulatory hubs in development, disease and evolution [PDF]

Frontiers in Cell and Developmental Biology, 2022
Ubiquitination of cellular proteins plays critical roles in key signalling pathways and in the regulation of protein turnover in eukaryotic cells. E2 ubiquitin conjugating enzymes function as essential intermediates in ubiquitination reactions by acting ...
Monica Roman-Trufero, Niall Dillon
doaj   +2 more sources

Preferential Interaction of Sentrin with a Ubiquitin-conjugating Enzyme, Ubc9 [PDF]

Journal of Biological Chemistry, 1997
Sentrin is a ubiquitin-like molecule that has been shown to interact with the death domains of Fas and tumor necrosis factor receptor 1 (TNFR1), PML, Rad51, Rad52, and RanGAP1. We have reported previously that sentrin can be conjugated to other proteins in a manner analogous to protein ubiquitination (Kamitani, T., Nguyen, H. P., and Yeh, E. T.
Limin Gong, Tetsu Kamitani, Kenichi Fujise, Laura S. Caskey, Edward T.H. Yeh   +4 more
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Cyclization of Polyubiquitin by the E2-25K Ubiquitin Conjugating Enzyme [PDF]

Journal of Biological Chemistry, 2000
For most substrates of ubiquitin (Ub)-dependent degradation, recognition by the proteasome is mediated by a covalently attached signal assembled from multiple ubiquitins linked to each other via the C terminus of one Ub and the epsilon-amine of Lys(48) of another Ub.
Tingting Yao, Robert E. Cohen
openalex   +4 more sources

UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination. [PDF]

J Biol Chem, 2014
Background: Ubiquitin-modified TDP-43 protein aggregates characterize common neurodegenerative diseases. Results: UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y (UBPY) are functional interactors of TDP-43 in cell culture and fly models.
Hans F, Fiesel FC, Strong JC, Jäckel S, Rasse TM, Geisler S, Springer W, Schulz JB, Voigt A, Kahle PJ.   +9 more
europepmc   +2 more sources

Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes [PDF]

Nature Communications, 2023
UBA1 is the primary E1 ubiquitin-activating enzyme responsible for generation of activated ubiquitin required for ubiquitination, a process that regulates stability and function of numerous proteins.
Wenjing Yan, Yongwang Zhong, Xin Hu, Tuan Xu, Yinghua Zhang, Stephen Kales, Yanyan Qu, Daniel C. Talley, Bolormaa Baljinnyam, Christopher A. LeClair, Anton Simeonov, Brian M. Polster, Ruili Huang, Yihong Ye, Ganesha Rai, Mark J. Henderson, Dingyin Tao, Shengyun Fang   +17 more
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Mechanism and Disease Association With a Ubiquitin Conjugating E2 Enzyme: UBE2L3 [PDF]

Frontiers in Immunology, 2022
Ubiquitin conjugating enzyme E2 is an important component of the post-translational protein ubiquitination pathway, which mediates the transfer of activated ubiquitin to substrate proteins.
Xiaoxia Zhang, Xiaoxia Zhang, Chengdong Huo, Chengdong Huo, Yating Liu, Ruiliang Su, Yang Zhao, Yumin Li   +7 more
doaj   +3 more sources

Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes [PDF]

Communications Biology
Proteins can be targeted for degradation by engineering biomolecules that direct them to the eukaryotic ubiquitination machinery. For instance, the fusion of an E3 ubiquitin ligase to a suitable target binding domain creates a ‘biological Proteolysis ...
Jonathan D. Taylor, Nathalie Barrett, Sergio Martinez Cuesta, Katelyn Cassidy, Fiona Pachl, James Dodgson, Radhika Patel, Tuula M. Eriksson, Aidan Riley, Matthew Burrell, Christin Bauer, D. Gareth Rees, Raffaello Cimbro, Andrew X. Zhang, Ralph R. Minter, James Hunt, Sandrine Legg   +16 more
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Tomato nuclear proteome reveals the involvement of specific E2 ubiquitin-conjugating enzymes in fruit ripening. [PDF]

Genome Biol, 2014
BackgroundFruits are unique to flowering plants and play a central role in seed maturation and dispersal. Molecular dissection of fruit ripening has received considerable interest because of the biological and dietary significance of fruit.
Wang Y, Wang W, Cai J, Zhang Y, Qin G, Tian S.   +5 more
europepmc   +2 more sources

The role of ubiquitin-conjugating enzyme in the process of spermatogenesis

Reproductive Biology and Endocrinology
The ubiquitination is crucial for controlling cellular homeostasis and protein modification, in which ubiquitin-conjugating enzyme (E2) acts as the central player in the ubiquitination system.
Peng Lv, Jihong Liu, Xiaming Liu
doaj   +3 more sources

Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium. [PDF]

PLoS Pathogens
The ubiquitin-proteasome system (UPS) is essential for Plasmodium falciparum survival and represents a potential target for antimalarial therapies. We utilised a ubiquitin- activity based probe (Ub-Dha) to capture active components of the ubiquitin ...
Cameron Smith, Mohsen Hajisadeghian, Gerbrand J van der Heden van Noort, Michael J Deery, Adán Pinto-Fernández, Benedikt M Kessler, Katerina Artavanis-Tsakonas   +6 more
doaj   +2 more sources