Results 11 to 20 of about 39,918 (341)

Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation [PDF]

BMC Cell Biology, 2007
Background Protein aggregation is a hallmark of several neurodegenerative diseases including Huntington's disease and Parkinson's disease. Proteins containing long, homopolymeric stretches of glutamine are especially prone to form aggregates. It has long
Caldwell Guy A, Caldwell Kim A, Hajjar Connie, Sharma Pratima, Howard Rebecca A, du Breuil Rusla, Moore Rhonda, Boyd Lynn   +7 more
doaj   +3 more sources

Ubiquitin-Conjugating Enzyme Gene [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Ubiquitin-Conjugating Enzyme E2 A [PDF]

, 2020
National Cancer Institute
openalex   +2 more sources

Creation of a Pluripotent Ubiquitin-Conjugating Enzyme [PDF]

Molecular and Cellular Biology, 2001
We describe the creation of a pluripotent ubiquitin-conjugating enzyme (E2) generated through a single amino acid substitution within the catalytic domain of RAD6 (UBC2). This RAD6 derivative carries out the stress-related function of UBC4 and the cell cycle function of CDC34 while maintaining its own DNA repair function.
Christopher P. Ptak, Chantelle Gwozd, J. Torin Huzil, Todd J. Gwozd, Grace Garen, Michael J. Ellison   +5 more
openalex   +4 more sources

The lysine deprotonation mechanism in a ubiquitin conjugating enzyme [PDF]

The Journal of Physical Chemistry B
Ubiquitination is a biochemical reaction in which a small protein, ubiquitin (Ub), is covalently linked to a lysine on a target protein. This type of post-translational modification can signal for protein degradation, DNA repair, or inflammation response.
Alexis J. Wathan, Nicole M. Deschene, Julie Litz, Isaiah Sumner   +3 more
openalex   +3 more sources

Functional Diversity and Structural Disorder in the Human Ubiquitination Pathway [PDF]

, 2013
The ubiquitin-proteasome system plays a central role in cellular regulation and protein quality control (PQC). The system is built as a pyramid of increasing complexity, with two E1 (ubiquitin activating), few dozen E2 (ubiquitin conjugating) and several
A Arrigoni, A Hershko, A Mohan, AE Deffenbaugh, B Bothner, B Hao, B Hess, C Guda, C Haynes, CJ Cox, CM Pickart, D Ekman, D Szklarczyk, D Van Der Spoel, D Vuzman, DM Duda, DM Duda, DW Leung, ES Zimmerman, ET Powers, F Bernassola, F Tama, F. Gisou van der Goot, FU Hartl, G Bussi, G Moncalian, G Swaminathan, G Wu, H Daub, H Dinkel, H Dou, H Shimizu, H Zhu, HC van Leeuwen, HE Niessen, HJ Dyson, HM Berman, I Szymkiewicz, I von Ossowski, J Liu, J Ma, J Prilusky, JC Rosenbaum, JH Fong, JM Huibregtse, K Peng, K Suhre, L Aravind, L Yang, LM Iakoucheva, M Christen, M Cormont, M Fuxreiter, M Fuxreiter, M Guharoy, M Hochstrasser, M Kanehisa, M Kanehisa, M Kanehisa, M Vidal, M Zhao, MA McCoy, Mainak Guharoy, MD Petroski, MD Petroski, ME Sowa, N Foray, N Mathias, N Zheng, P Tompa, P Tompa, P Tompa, P Tompa, P Tompa, Pallab Bhowmick, PE Ryan, PE Wright, Peter Tompa, PW Hildebrand, R Kiss, RG Smock, Rita Pancsa, RJ Deshaies, S Fishbain, S Vucetic, S Wiesner, SC Kales, SJ Demarest, SJ van Wijk, T Hagai, T Inobe, T Mittag, T Ravid, U Emekli, VN Uversky, W Humphrey, W Li, WY Mark, X Zhong, Y Haupt, Y Sheng, Y Xie, Z Dosztanyi, Z Dosztanyi, Z Dosztanyi   +104 more
core   +14 more sources

Targeting neddylation E2s: a novel therapeutic strategy in cancer

Journal of Hematology & Oncology, 2021
Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F (UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part in posttranslational modification and change the activity of target proteins.
Yi-Chao Zheng, Yan-Jia Guo, Bo Wang, Chong Wang, M. A. A. Mamun, Ya Gao, Hong-Min Liu   +6 more
doaj   +1 more source

Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate [PDF]

Biochemistry, 2011
Ubiquitination of proteins provides a powerful and versatile post-translational signal in the eukaryotic cell. The formation of a thioester bond between ubiquitin (Ub) and the active site of a ubiquitin-conjugating enzyme (E2) is critical for the transfer of Ub to substrates. Assembly of a functional ubiquitin ligase (E3) complex poised for Ub transfer
Jonathan N, Pruneda, Kate E, Stoll, Laura J, Bolton, Peter S, Brzovic, Rachel E, Klevit   +4 more
openaire   +2 more sources

Mechanism and Disease Association With a Ubiquitin Conjugating E2 Enzyme: UBE2L3

Frontiers in Immunology, 2022
Ubiquitin conjugating enzyme E2 is an important component of the post-translational protein ubiquitination pathway, which mediates the transfer of activated ubiquitin to substrate proteins.
Xiaoxia Zhang, Xiaoxia Zhang, Chengdong Huo, Chengdong Huo, Yating Liu, Ruiliang Su, Yang Zhao, Yumin Li   +7 more
doaj   +1 more source

Robust high-throughput assays to assess discrete steps in ubiquitination and related cascades

BMC Molecular and Cell Biology, 2020
Background Ubiquitination and ubiquitin-like protein post-translational modifications play an enormous number of roles in cellular processes. These modifications are constituted of multistep reaction cascades.
Gabriel Fenteany, Paras Gaur, Gaurav Sharma, Lajos Pintér, Ernő Kiss, Lajos Haracska   +5 more
doaj   +1 more source