Results 41 to 50 of about 63,885 (332)

The ubiquitin-proteasome system is required for African swine fever replication. [PDF]

PLoS ONE, 2017
Several viruses manipulate the ubiquitin-proteasome system (UPS) to initiate a productive infection. Determined viral proteins are able to change the host's ubiquitin machinery and some viruses even encode their own ubiquitinating or deubiquitinating ...
Lucía Barrado-Gil, Inmaculada Galindo, Diego Martínez-Alonso, Sergio Viedma, Covadonga Alonso   +4 more
doaj   +1 more source

Structural Diversity of Ubiquitin E3 Ligase

Molecules, 2021
The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes ...
Sachiko Toma-Fukai, Toshiyuki Shimizu
doaj   +1 more source

Two Ubiquitin-Conjugating Enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, Have Distinct Functions for Ubiquitination of Mitotic Cyclin

Molecular and Cellular Biology, 2003
Hiroaki Seino, Tsutomu Kishi, Hideo Nishitani, Fumiaki Yamao   +3 more
openalex   +2 more sources

Evidence for a particulate location of ubiquitin conjugates and ubiquitin-conjugating enzymes in rabbit brain.

Journal of Biological Chemistry, 1991
Conjugate ubiquitin was previously found in the nucleus, cytoplasm, and membranes of eukaryotic cells while the enzymes of the ubiquitin-conjugating system appear to be cytoplasmic. We have prepared the mitochondrial fraction from rabbit brain by discontinuous density gradient ultracentrifugation and by Western blotting, using a specific antibody ...
MAGNANI, MAURO, G. SERAFINI, ANTONELLI, ANTONELLA, M. MALATESTA, G. GAZZANELLI   +4 more
openaire   +5 more sources

An Allosteric Inhibitor of the Human Cdc34 Ubiquitin-Conjugating Enzyme [PDF]

Cell, 2011
In the ubiquitin-proteasome system (UPS), E2 enzymes mediate the conjugation of ubiquitin to substrates and thereby control protein stability and interactions. The E2 enzyme hCdc34 catalyzes the ubiquitination of hundreds of proteins in conjunction with the cullin-RING (CRL) superfamily of E3 enzymes.
Xiaojing Tang, Derek F. Ceccarelli, Joanna Koszela, Masoud Vedadi, Jeff Wrana, Shuichan Xu, Veronique Plantevin, Frank Mercurio, Dante Neculai, Dante Neculai, Sylvain Meloche, Abiodun A. Ogunjimi, Sirano Dhe-Paganon, Weilin Xie, David R. Webb, Antonia Lopez-Girona, Stephen Orlicky, Yang-Chieh Chou, Yang-Chieh Chou, Mike Tyers, Mike Tyers, Mike Tyers, Sarah Cox, Gregory A. Wasney, Abdallah Al-Hakim, Xaralabos Varelas, Daniel Durocher, Frank Sicheri, Frank Sicheri, Benoit Pelletier   +29 more
openaire   +3 more sources

Quantitative proteome dataset profiling of UBC4 and UBC5 deletion strains in Saccharomyces cerevisiae

Data in Brief, 2022
The Ubiquitin-Proteasome System (UPS) regulates many cellular processes in eukaryotic cells. Ubiquitylation by the UPS mainly directs proteins to proteasomal degradation, but it can also have non-degradative functions, such as regulating protein activity
Valentina Rossio, Joao A Paulo
doaj  

TULIP2: An Improved Method for the Identification of Ubiquitin E3-Specific Targets

Frontiers in Chemistry, 2019
Protein modification by Ubiquitin or Ubiquitin-like modifiers is mediated by an enzyme cascade composed of E1, E2, and E3 enzymes. E1s, or ubiquitin-activating enzymes, perform ubiquitin activation. Next, ubiquitin is transferred to ubiquitin-conjugating
Daniel Salas-Lloret, Giulia Agabitini, Román González-Prieto   +2 more
doaj   +1 more source

The HIP2~ubiquitin conjugate forms a non-compact monomeric thioester during di-ubiquitin synthesis. [PDF]

PLoS ONE, 2015
Polyubiquitination is a post-translational event used to control the degradation of damaged or unwanted proteins by modifying the target protein with a chain of ubiquitin molecules.
Benjamin W Cook, Kathryn R Barber, Brian H Shilton, Gary S Shaw   +3 more
doaj   +1 more source

Wheat germ-based protein libraries for the functional characterisation of the Arabidopsis E2 ubiquitin conjugating enzymes and the RING-type E3 ubiquitin ligase enzymes

BMC Plant Biology, 2015
BackgroundProtein ubiquitination is a ubiquitous mechanism in eukaryotes. In Arabidopsis, ubiquitin modification is mainly mediated by two ubiquitin activating enzymes (E1s), 37 ubiquitin conjugating enzymes (E2s), and more than 1300 predicted ubiquitin ...
Abdelaziz Ramadan, Keiichirou Nemoto, M. Seki, K. Shinozaki, H. Takeda, Hirotaka Takahashi, T. Sawasaki   +6 more
semanticscholar   +1 more source

UBE2G1 governs the destruction of cereblon neomorphic substrates

eLife, 2018
The cereblon modulating agents (CMs) including lenalidomide, pomalidomide and CC-220 repurpose the Cul4-RBX1-DDB1-CRBN (CRL4CRBN) E3 ubiquitin ligase complex to induce the degradation of specific neomorphic substrates via polyubiquitination in ...
Gang Lu, Stephanie Weng, Mary Matyskiela, Xinde Zheng, Wei Fang, Scott Wood, Christine Surka, Reina Mizukoshi, Chin-Chun Lu, Derek Mendy, In Sock Jang, Kai Wang, Mathieu Marella, Suzana Couto, Brian Cathers, James Carmichael, Philip Chamberlain, Mark Rolfe   +17 more
doaj   +1 more source