Results 51 to 60 of about 39,918 (341)

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry [PDF]

, 2014
Deubiquitylases (DUBs) are key regulators of the ubiquitin system which cleave ubiquitin moieties from proteins and polyubiquitin chains. Several DUBs have been implicated in various diseases and are attractive drug targets. We have developed a sensitive
A Iphofer, A Kovalenko, A van der Horst, AC Faesen, AK Al-Hakim, AM Oliveira, B Nicholson, C Kondapalli, C Reverdy, D Bungert, D Komander, D Komander, D Komander, DW Lee, E Graner, E Szajli, EW Harhaj, F Colland, F El Oualid, F Ikeda, FE Reyes-Turcu, G Nicastro, H Mistry, HB Kramer, J Chen, J Hemelaar, J Liang, J McCullough, JF McGouran, JW Pierce, K Keusekotten, K Saigoh, L Daviet, LC Dang, LV Pham, M Altun, M Colombo, M Karas, M Li, M Pulvino, MJ Clague, MJ Lee, MK Hospenthal, N Krishnan, NL Anderson, OW Huang, P Cohen, P Rufenacht, R Ekkebus, RA Horton, S Strickson, S Virdee, SD Sherrod, SJ Orcutt, SM Nijman, SM Nijman, SP Shah, TE Messick, TE Mevissen, U Hassiepen, Y Liu, Y Takano, Y Zhang   +62 more
core   +3 more sources

Cytosolic chaperones influence the fate of a toxin dislocated from the endoplasmic reticulum [PDF]

, 2008
The plant cytotoxin ricin enters target mammalian cells by receptor-mediated endocytosis and undergoes retrograde transport to the endoplasmic reticulum (ER).
Argent, Argent, Arndt, Brodsky, Brodsky, C. Rogon, Chaddock, Chen, Hudson, Hundley, H  hfeld, J. Hohfeld, J. M. Lord, J. P. Cook, L. M. Roberts, Lawson, Luders, Meacham, Meusser, Nakatsukasa, Nakatsukasa, P. J. Hart, P. Pietroni, R. A. Spooner, Rapak, Roe, Savino, Spooner, Urushitani, van Deurs, Wales, Wesche, Younger   +32 more
core   +4 more sources

Ubiquitin-Conjugating Enzyme OsUBC11 Affects the Development of Roots via Auxin Pathway

Rice, 2023
Rice has 48 ubiquitin-conjugating enzymes, and the functions of most of these enzymes have not been elucidated. In the present study, a T-DNA insertional mutant named R164, which exhibited a significant decrease in the length of primary and lateral roots,
Yunfei Han, Chuanzhong Zhang, Hanjing Sha, Xiaojing Wang, Yue Yu, Jia Liu, Guangxin Zhao, Jingying Wang, Guankai Qiu, Xingjian Xu, Jun Fang   +10 more
doaj   +1 more source

Mechanism and disease-association of E2 conjugating enzymes:lessons from UBE2T and UBE2L3 [PDF]

, 2016
Ubiquitin signalling is a fundamental eukaryotic regulatory system, controlling diverse cellular functions. A cascade of E1, E2, and E3 enzymes is required for assembly of distinct signals, whereas an array of deubiquitinases and ubiquitin-binding ...
Alfano, Ali, Alpi, Alpi, Alter, Arno F. Alpi, Benirschke, Berndsen, Bogliolo, Boisson, Boisson, Brzovic, Buetow, Burroughs, Cantor, Ceccaldi, Charan, Chaugule, Chiu, Chong, Christensen, Christensen, Ciccia, Clague, Clague, Cole, Cook, Corson, Das, Das, Dawson, Devine, Dorsman, Dou, Dou, Dove, Dubois, Duda, Duxin, Eddins, Eletr, Eletr, Enchev, Fiesel, Flotho, Franke, Galanty, Gao, Garaycoechea, Garcia-Higuera, Gateva, Geisler, Gerlach, Grishin, Hamilton, Han, Hao, Hasebe, Hatakeyama, Heideker, Helen Walden, Hibbert, Hinks, Hira, Hodson, Hodson, Hu, Huang, Huang, Husnjak, Iguchi, Ikeda, Jin, Jostins, Juang, Kamadurai, Kane, Kar, Kazlauskaite, Kelsall, Kelsall, Kim, Kirisako, Kitada, Kondapalli, Koyano, Kulathu, Kumar, Kumar, Kumari, Langevin, Lechtenberg, Lewis, Li, Li, Li, Ling, Liu, Lobitz, Lopez-Martinez, Lorenz, Loveday, Mace, Machida, Mackay, Markson, Maure, McGinty, Meetei, Meetei, Meetei, Meindl, Metzger, Metzger, Michelle, Middleton, Mosedale, Mulder, Nakada, Nascimento, Nuber, Orozco, Page, Pao, Parker, Peltzer, Pelzer, Perkins, Petroski, Pickart, Plechanovová, Pontel, Pruneda, Pruneda, Rahman, Rajendra, Ravid, Rickard, Rickman, Rodrigo-Brenni, Rodrigo-Brenni, Ronchi, Rosado, Roy, Saha, Sarcevic, Scheffner, Schulman, Schumacher, Shchebet, Sheng, Sims, Singh, Sloper-Mould, Smogorzewska, Spratt, Spratt, Stahl, Stewart, Stieglitz, Streich, Sun, Tatham, Tokunaga, Trempe, Tsoi, Turco, Ueki, Valimberti, van Wijk, van Wijk, Viduth Chaugule, Virts, Vittal, Voutsadakis, Wang, Wang, Wang, Wauer, Wen, Wenzel, Wickliffe, Wiener, Windheim, Wood, Wooster, Xu, Yan, Yang, Yin, Yu, Zhang, Ziemba   +192 more
core   +5 more sources

Genome-Wide Identification, Phylogenetic and Expression Analyses of the Ubiquitin-Conjugating Enzyme Gene Family in Maize.

PLoS ONE, 2015
BackgroundUbiquitination is a post-translation modification where ubiquitin is attached to a substrate. Ubiquitin-conjugating enzymes (E2s) play a major role in the ubiquitin transfer pathway, as well as a variety of functions in plant biological ...
Dengwei Jue, Xuelian Sang, Shengqiao Lu, Chen Dong, Qiufang Zhao, Hongliang Chen, Liqiang Jia   +6 more
doaj   +1 more source

How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]

, 2017
Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias, Mukherjee, Shaeri, Schlaermann, Philipp   +2 more
core   +2 more sources

Ubiquitin- and ubiquitin-like proteins-conjugating enzymes (E2s) in breast cancer [PDF]

, 2018
Breast cancer is the most common malignancy in women and a significant cause of morbidity and mortality. Sub-types of breast cancer defined by the expression of steroid hormones and Her2/Neu oncogene have distinct prognosis and undergo different ...
Voutsadakis, Ioannis
core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

A quantitative assay to monitor HSV-1 ICP0 ubiquitin ligase activity in vitro [PDF]

, 2015
The ubiquitin–proteasome system is an essential cellular process that plays a fundamental role in the regulation of protein stability. This pathway is tightly controlled by a sequential cascade of enzymatic steps that culminates in the formation of a ...
Boutell, Chris, Davido, David J.
core   +2 more sources

Determinants of Functionality in the Ubiquitin Conjugating Enzyme Family [PDF]

Structure, 2004
The E2 enzymes are key enzymes in the ubiquitin and ubiquitin-like protein ligation pathways. To understand the functionality of the different E2 enzymes, we analyzed 190 protein sequences and 211 structures and electrostatic potentials. Key findings include: The ScUbc1 orthologs are defined by a C-terminal UBA domain. An N-terminal sequence motif that
Winn, Peter J., Religa, Tomasz L., Battey, James N.D., Banerjee, Amit, Wade, Rebecca C.   +4 more
openaire   +2 more sources