Results 51 to 60 of about 63,885 (332)
Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1
Antioxidants, 2023 Protein ubiquitination, which is catalyzed by ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin ligases, is a crucial post-translational modification to regulate numerous cellular functions in a spatio–temporal-specific manner ...
Daisuke Oikawa +2 more
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International Journal of Molecular Sciences, 2020 Owing to a sessile lifestyle in nature, plants are routinely faced with diverse hostile environments such as various abiotic and biotic stresses, which lead to accumulation of free radicals in cells, cell damage, protein denaturation, etc., causing ...
Weigang Liu +8 more
semanticscholar +1 more source
Erythrocyte Spectrin Is an E2 Ubiquitin Conjugating Enzyme
Biochemistry, 2001 The involvement of red blood cell spectrin in the ubiquitination process was studied. Spectrin was found to form two ubiquitin-associated derivatives, a DTT-sensitive ubiquitin adduct and a DTT-insensitive conjugate, characteristic intermediate and final products of the ubiquitination reaction cascade.
Jardine I +6 more
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Frontiers in Genetics, 2021 Notch signaling pathway plays crucial roles in animal development. Protein ubiquitination contributes to Notch signaling regulation by governing the stability and activity of major signaling components.
Fengchao Zhang +3 more
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Huntingtin Is Ubiquitinated and Interacts with a Specific Ubiquitin-conjugating Enzyme [PDF]
Journal of Biological Chemistry, 1996 Using the yeast two-hybrid system, we have identified a human ubiquitin-conjugating enzyme (hE2-25K) as a protein that interacts with the gene product for Huntington disease (HD) (Huntingtin). This protein has complete amino acid identity with the bovine E2-25K protein and has striking similarity to the UBC-1, -4 and -5 enzymes of Saccharomyces ...
Gang Xia +9 more
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Poxvirus Interactions with the Host Ubiquitin System
Pathogens, 2021 The ubiquitin system has emerged as a master regulator of many, if not all, cellular functions. With its large repertoire of conjugating and ligating enzymes, the ubiquitin system holds a unique mechanism to provide selectivity and specificity in ...
Sian Lant, Carlos Maluquer de Motes
doaj +1 more source
Mechanisms of Generating Polyubiquitin Chains of Different Topology
Cells, 2014 Ubiquitination is an important post-translational process involving attachment of the ubiquitin molecule to lysine residue/s on a substrate protein or on another ubiquitin molecule, leading to the formation of protein mono-, multi- or polyubiquitination.
Randy Suryadinata +3 more
doaj +1 more source
Interplay between the Ubiquitin Proteasome System and Ubiquitin-Mediated Autophagy in Plants
Cells, 2020 All eukaryotes rely on the ubiquitin-proteasome system (UPS) and autophagy to control the abundance of key regulatory proteins and maintain a healthy intracellular environment. In the UPS, damaged or superfluous proteins are ubiquitinated and degraded in
Tong Su +4 more
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A Yeast-Based Functional Assay to Study Plant N-Degron – N-Recognin Interactions
Frontiers in Plant Science, 2022 The N-degron pathway is a branch of the ubiquitin-proteasome system where amino-terminal residues serve as degradation signals. In a synthetic biology approach, we expressed ubiquitin ligase PRT6 and ubiquitin conjugating enzyme 2 (AtUBC2) from ...
Aida Kozlic +11 more
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Sequence of a Cloned Tomato Ubiquitin Conjugating Enzyme
Plant Physiology, 1993 Ubiquitin is a small, abundant protein that is seemingly present in a11 eukaryotic cells and that is covalently ligated to specific protein substrates via an ATP-dependent reaction. This ubiquitinous has been demonstrated to target proteins for subsequent cellular degradation.
Sarah Louise Barton +4 more
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