Results 131 to 140 of about 98,327 (230)

A Spatiotemporally Controlled Nanoplatform for Photothermal BRD4 Degradation Enables Synergistic Cancer Immunotherapy

Advanced Science, EarlyView.
A GSH‐responsive MOF nanoplatform acts as a Photothermolysis‐Targeting Conjugate (PTTAC). Through sophisticated step‐wise nuclear delivery, it enables NIR‐II light‐triggered photothermal degradation of BRD4. This precise strategy induces robust immunogenic cell death (ICD) and powerfully synergizes with anti‐PD‐L1 blockade to elicit a potent systemic ...
Luyi Wang, Jiasha Wu, Rui Ji, Sufeng Qiang, Yulin Shen, Yan Zuo, Shiqin Jian, Siyao Liu, Fusheng Xu, Honggang Hu, Xiaochun Hu   +10 more
wiley   +1 more source

Modulation of the tumor microenvironment by the ubiquitin-proteasome system in colorectal cancer. [PDF]

J Transl Med
Wang X, Ren Y, Song R, Liu J, Zhou Y, Yang S, Liu Y, Lei Y, Zhao X.   +8 more
europepmc   +1 more source

Cholesterol Promotes Lung Adenocarcinoma Brain Metastasis by Stabilizing EGFR Protein to Drive EMT, Metabolic Reprogramming, and Premetastatic Niche Formation

Advanced Science, EarlyView.
Cholesterol is revealed as a multitasking fuel for lung adenocarcinoma brain metastasis: it locks EGFR at the membrane to sustain AKT/NF‐κB–driven glycolysis and EMT, loosens the blood–brain barrier by promoting Claudin‐5 loss, and rewires microglia through IL‐4R lipid‐raft–JAK1/STAT6 signaling.
Ying Chen, Xiaoteng Cui, Xinyi Shi, Xu Yang, Yujing Cao, Haolin LI, Qi Zhan, Qixue Wang, Ang Li, Qihong Cheng, Yunfei Wang, Junhu Zhou, MingJie Wang, Chunsheng Kang, Xiaomin Liu   +14 more
wiley   +1 more source

Versatile roles of inositol hexakisphosphate in the ubiquitin-proteasome system. [PDF]

Essays Biochem
Rusnac DV, Zheng N, Xie X.
europepmc   +1 more source

A Novel GmSIN1‐GmRNF1a‐GmCSN5a Module Determines Soybean Salt Tolerance and Yield Under Saline Soil Conditions

Advanced Science, EarlyView.
Soybean production is severely threatened by salt stress. This study reveals that the GmSIN1‐GmRNF1a‐GmCSN5a module enhances salt tolerance by stabilizing the GmSIN1 protein. GmRNF1a acts as an E3 ligase to ubiquitinate GmSIN1 for degradation, a process inhibited by GmCSN5a.
Jinlong Xu, Mengqi Shan, Xinxin Yang, Rongmei Zhao, Mengke Zhang, Guohua Bao, Lili Wang, Mingru Li, Wenjiao Zhi, Muzi Wang, Tianshi Liu, Xiaojian Zheng, Wenyu Zheng, Qing Lu, Shuo Li, Fengning Xiang   +15 more
wiley   +1 more source

Targeting the Ubiquitin-Proteasome System in Atrial Fibrillation: Mechanistic Insights and Translational Perspectives. [PDF]

Curr Issues Mol Biol
Huang R, Pu Z, Chen Z.
europepmc   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

The ubiquitin-proteasome system in Alzheimer's disease: mechanism of action and current status of treatment. [PDF]

Front Aging Neurosci
Jia S, Li Q, Rui X, Qin W, Zhang W, Dou J, Zhang X.   +6 more
europepmc   +1 more source

Editorial: The ubiquitin-proteasome system and cellular signaling: mechanisms and regulatory roles in cancer and infectious diseases. [PDF]

Front Cell Dev Biol
Islam S, Hussain A, Alam A, Ansari MO, Saeed H, Khan S.   +5 more
europepmc   +1 more source

The ubiquitin-proteasome system in circadian regulation. [PDF]

Front Neurosci
Costanzo KM, Prifti MV, Todi SV, Mohan RD.   +3 more
europepmc   +1 more source