Results 181 to 190 of about 98,327 (230)

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Stress responses induced by perturbation of the ubiquitin-proteasome system. [PDF]

Trends Biochem Sci
Rai M, Hunt LC, Demontis F.
europepmc   +1 more source

Association between serum bicarbonate and low mid‐upper arm circumference in patients with non‐dialysis‐dependent chronic kidney disease: A cross‐sectional study

Nutrition in Clinical Practice, EarlyView.
Abstract Background Although previous experimental studies showed that metabolic acidosis promoted muscle catabolism and impaired protein synthesis, few epidemiological studies reported an independent association between serum bicarbonate levels and muscle atrophy in patients with chronic kidney disease (CKD).
Nobuhisa Morimoto, Shintaro Mandai, Tamami Fujiki, Fumiaki Ando, Takayasu Mori, Koichiro Susa, Shotaro Naito, Eisei Sohara, Tatsuhiko Anzai, Kunihiko Takahashi, Wataru Akita, Akihito Ohta, Shinichi Uchida, Soichiro Iimori   +13 more
wiley   +1 more source

A DUF3455 domain‐containing protein promotes Ustilaginoidea virens infection and functions as a plant immune elicitor

New Plant Protection, EarlyView.
The fungal effector UvDUF1 from Ustilaginoidea virens not only promotes infection but also acts as a plant immunity elicitor, inducing broad‐spectrum disease resistance in rice and Nicotiana benthamiana. These results reveal its potential as a novel target for sustainable crop protection strategies.
Shuchen Wang, Wen Zhang, Wenyue Zheng, Qian Zhang, Mina Yu, Junjie Yu, Huijuan Cao, Xiayan Pan, Zhongqiang Qi, Yan Du, Rongsheng Zhang, Yunpeng Wang, Yongfeng Liu, Tianqiao Song   +13 more
wiley   +1 more source

Combating Malaria: Targeting the Ubiquitin-Proteasome System to Conquer Drug Resistance. [PDF]

Trop Med Infect Dis
Sanaullah B, Truong NV, Nguyen TK, Han ET.   +3 more
europepmc   +1 more source

Design and Synthesis of Polyamine‐Proteolysis Targeting Chimera Conjugates for Histone Deacetylase (HDAC) Degradation with Enhanced Cellular Uptake

ChemistryOpen, EarlyView.
In this article, proteolysis targeting chimeras (PROTACs) bearing a polyamine linker capable of crossing cancer cell membranes via the polyamine transport system are synthesized and evaluated. The results provide valuable insights for the design of PROTACs with enhanced cellular uptake efficiency.
Yanran Liu, Wentian Chen, Yanwei Shang, Chaonan Tang, Xianming Zeng, Jun Li, Wenting Du   +6 more
wiley   +1 more source

Mechanistic Insights and Therapeutic Potentials of Ubiquitin-Proteasome System in Non-Small Cell Lung Cancer. [PDF]

Cell Prolif
Zhou G, Tan J, Zhang P, Zhou Z, Zhang L, Zhang Z.   +5 more
europepmc   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Molecular mechanisms and potential targeting strategies of ubiquitin‑proteasome system‑mediated PD‑1/PD‑L1 ubiquitination in tumor immune suppression (Review). [PDF]

Oncol Rep
Gu LH, Guo A, Ding YY, Wang XJ, Zhang HX, Duan WL, Zhang BG.   +6 more
europepmc   +1 more source

Clinicopathological characteristics of patients with inoperable non‐small cell lung cancer harboring circulating NRF2 pathway mutations

The Journal of Pathology, EarlyView.
Abstract Lung cancer is the leading cause of global cancer‐related morbidity and mortality, with tobacco smoking as its strongest risk factor. Nuclear factor erythroid 2‐related factor 2 (NRF2) is a redox‐regulated transcription factor frequently dysregulated in non‐small cell lung cancer (NSCLC), leading to aggressive disease and resistance to therapy.
Jouni Härkönen, Satu Tiainen, Jouni Kujala, Linnea Muhonen, Ponnuswamy Mohanasundaram, Tuomas Tikkanen, Ina Pöhner, Tommi Patinen, Simone Adinolfi, Juha P Väyrynen, Päivi Auvinen, Arto Mannermaa, Petri Pölönen, Tuomas Rauramaa, Anna‐Liisa Levonen   +14 more
wiley   +1 more source