Results 281 to 290 of about 17,362,245 (308)

Ubiquitin–Proteasome System and mitochondria — Reciprocity

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011
Recently, sporadic links have been published between mitochondria - membrane-confined organelles - and the cytosolic ubiquitin-proteasome system (UPS) for removal of cellular proteins. For example, Fzo1, a mitochondrial outer membrane mitofusin was shown to be ubiquitinated by a ubiquitin ligase, Cdc53(MDM30), and degraded by the proteasome.
Nurit, Livnat-Levanon, Michael H, Glickman   +1 more
openaire   +2 more sources

Drug discovery in the ubiquitin–proteasome system

Nature Reviews Drug Discovery, 2006
Regulated protein turnover via the ubiquitin-proteasome system (UPS) underlies a wide variety of signalling pathways, from cell-cycle control and transcription to development. Recent evidence that pharmacological inhibition of the proteasome can be efficacious in the treatment of human cancers has set the stage for attempts to selectively inhibit the ...
Grzegorz, Nalepa, Mark, Rolfe, J Wade, Harper   +2 more
openaire   +2 more sources

Transcriptional Control and the Ubiquitin–Proteasome System

2008
Regulation of transcription is a critically important process that controls development, differentiation, and the maintenance of cellular homeostasis. Cells have evolved numerous mechanisms to keep gene transcription tightly in check, some of which involve the ubiquitin-proteasome system.
A, Leung, F, Geng, A, Daulny, G, Collins, P, Guzzardo, W P, Tansey   +5 more
openaire   +2 more sources

The role of ubiquitin–proteasome system in ageing

General and Comparative Endocrinology, 2011
Maintenance of cellular homeostasis influences ageing and it is determined by several factors, including efficient proteolysis of damaged proteins. The ubiquitin-proteasome system is the major protein degradation pathway in the cell. Specifically, the proteasome is responsible for clearance of abnormal, denatured or in general damaged proteins as well ...
openaire   +2 more sources

Out of Control: The Role of the Ubiquitin Proteasome System in Skeletal Muscle during Inflammation

Biomolecules, 2021
Jens Fielitz, Elke Krueger
exaly  

The Ubiquitin Conjugating Enzyme: An Important Ubiquitin Transfer Platform in Ubiquitin-Proteasome System

International Journal of Molecular Sciences, 2020
Xue Fu, Weigang Liu, Shantwana Ghimire   +2 more
exaly  

The ubiquitin–proteasome system links NADPH metabolism to ferroptosis

Trends in Cell Biology, 2023
Cheol-Sang Hwang, Yoontae Lee, Jihye Yang   +2 more
exaly  

The Ubiquitin–Proteasome System (UPS) and Viral Infection in Plants

Plants, 2022
Tarazi R, Maite F S Vaslin, Dania P Lobaina   +2 more
exaly  

Interplay between the Ubiquitin Proteasome System and Ubiquitin-Mediated Autophagy in Plants

Cells, 2020
Pingping Wang, Yanxiu Zhao
exaly  

Targeting the Ubiquitin-Proteasome System for Cancer Therapeutics by Small-Molecule Inhibitors

Cancers, 2021

exaly