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How the ubiquitin–proteasome system controls transcription [PDF]
Nature Reviews Molecular Cell Biology, 2003 Gene transcription and ubiquitin-mediated proteolysis are two processes that have seemingly nothing in common: transcription is the first step in the life of any protein and proteolysis the last. Despite the disparate nature of these processes, a growing
William Tansey, Tansey William P
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The ubiquitin–proteasome system in cardiomyopathies
Current Opinion in Cardiology, 2011Fine equilibrium between protein synthesis and protein degradation is essential for cell survival and function. After initial synthesis, membrane and secretory proteins are modified, folded, and assembled in the endoplasmic reticulum, whereas other proteins are synthesized and processed in the cytosol.
Saskia, Schlossarek, Lucie, Carrier
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Ubiquitin–Proteasome System in Spermatogenesis
2014Spermatogenesis represents a complex succession of cell division and differentiation events resulting in the continuous formation of spermatozoa. Such a complex program requires precise expression of enzymes and structural proteins which is effected not only by regulation of gene transcription and translation, but also by targeted protein degradation ...
Rohini, Bose +3 more
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Autophagy and Ubiquitin-Proteasome System
2019Millions of protein molecules are synthesized per minute in each cell, and simultaneously, millions of protein molecules are degraded. Mutated and misfolded newly synthesized proteins are rapidly degraded to prevent the toxicity caused by the accumulation of these protein fragments.
Yan, Wang, Wei-Dong, Le
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Ubiquitin–Proteasome System and mitochondria — Reciprocity
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011Recently, sporadic links have been published between mitochondria - membrane-confined organelles - and the cytosolic ubiquitin-proteasome system (UPS) for removal of cellular proteins. For example, Fzo1, a mitochondrial outer membrane mitofusin was shown to be ubiquitinated by a ubiquitin ligase, Cdc53(MDM30), and degraded by the proteasome.
Nurit, Livnat-Levanon +1 more
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The role of ubiquitin–proteasome system in ageing
General and Comparative Endocrinology, 2011Maintenance of cellular homeostasis influences ageing and it is determined by several factors, including efficient proteolysis of damaged proteins. The ubiquitin-proteasome system is the major protein degradation pathway in the cell. Specifically, the proteasome is responsible for clearance of abnormal, denatured or in general damaged proteins as well ...
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Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy
Open Biology, 2021Hamidreza Pazoki-Toroudi +2 more
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