Results 261 to 270 of about 164,141 (292)
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Autophagy and Ubiquitin-Proteasome System
2019Millions of protein molecules are synthesized per minute in each cell, and simultaneously, millions of protein molecules are degraded. Mutated and misfolded newly synthesized proteins are rapidly degraded to prevent the toxicity caused by the accumulation of these protein fragments.
Yan, Wang, Wei-Dong, Le
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Drug discovery in the ubiquitin–proteasome system
Nature Reviews Drug Discovery, 2006Regulated protein turnover via the ubiquitin-proteasome system (UPS) underlies a wide variety of signalling pathways, from cell-cycle control and transcription to development. Recent evidence that pharmacological inhibition of the proteasome can be efficacious in the treatment of human cancers has set the stage for attempts to selectively inhibit the ...
Grzegorz Nalepa, J Wade Harper
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Proteotoxic stress and the ubiquitin proteasome system
Seminars in Cell and Developmental BiologyThe ubiquitin proteasome system maintains protein homeostasis by regulating the breakdown of misfolded proteins, thereby preventing misfolded protein aggregates. The efficient elimination is vital for preventing damage to the cell by misfolded proteins, known as proteotoxic stress.
Rachel Kandel +2 more
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Ubiquitin–Proteasome System and mitochondria — Reciprocity
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011Recently, sporadic links have been published between mitochondria - membrane-confined organelles - and the cytosolic ubiquitin-proteasome system (UPS) for removal of cellular proteins. For example, Fzo1, a mitochondrial outer membrane mitofusin was shown to be ubiquitinated by a ubiquitin ligase, Cdc53(MDM30), and degraded by the proteasome.
Nurit, Livnat-Levanon +1 more
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Transcriptional Control and the Ubiquitin–Proteasome System
2008Regulation of transcription is a critically important process that controls development, differentiation, and the maintenance of cellular homeostasis. Cells have evolved numerous mechanisms to keep gene transcription tightly in check, some of which involve the ubiquitin-proteasome system.
A, Leung +5 more
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The role of ubiquitin–proteasome system in ageing
General and Comparative Endocrinology, 2011Maintenance of cellular homeostasis influences ageing and it is determined by several factors, including efficient proteolysis of damaged proteins. The ubiquitin-proteasome system is the major protein degradation pathway in the cell. Specifically, the proteasome is responsible for clearance of abnormal, denatured or in general damaged proteins as well ...
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Ubiquitin–proteasome system and the role of its inhibitors in cancer therapy
Open Biology, 2021Beheshteh Sohrabi +2 more
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The ubiquitin–proteasome system links NADPH metabolism to ferroptosis
Trends in Cell Biology, 2023Jihye Yang +2 more
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