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Studies of the Ubiquitin Proteasome System
Current Protocols in Cell Biology, 2006AbstractA concept that has arisen over the last decade is that proteins can, in general, be covalently modified by polypeptides, resulting in alterations in their fate and function. The first‐identified and most well studied of these modifying polypeptides is ubiquitin.
Kevin L, Lorick +4 more
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The ubiquitin–proteasome system in cardiomyopathies
Current Opinion in Cardiology, 2011Fine equilibrium between protein synthesis and protein degradation is essential for cell survival and function. After initial synthesis, membrane and secretory proteins are modified, folded, and assembled in the endoplasmic reticulum, whereas other proteins are synthesized and processed in the cytosol.
Saskia, Schlossarek, Lucie, Carrier
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Ubiquitin–Proteasome System in Spermatogenesis
2014Spermatogenesis represents a complex succession of cell division and differentiation events resulting in the continuous formation of spermatozoa. Such a complex program requires precise expression of enzymes and structural proteins which is effected not only by regulation of gene transcription and translation, but also by targeted protein degradation ...
Rohini, Bose +3 more
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Drug Discovery in the Ubiquitin–Proteasome System
Nature Reviews Drug Discovery, 2006Regulated protein turnover via the ubiquitin-proteasome system (UPS) underlies a wide variety of signalling pathways, from cell-cycle control and transcription to development. Recent evidence that pharmacological inhibition of the proteasome can be efficacious in the treatment of human cancers has set the stage for attempts to selectively inhibit the ...
Grzegorz Nalepa +2 more
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Autophagy and Ubiquitin-Proteasome System
2019Millions of protein molecules are synthesized per minute in each cell, and simultaneously, millions of protein molecules are degraded. Mutated and misfolded newly synthesized proteins are rapidly degraded to prevent the toxicity caused by the accumulation of these protein fragments.
Yan, Wang, Wei-Dong, Le
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Proteotoxic Stress and the Ubiquitin Proteasome System
Seminars in Cell and Developmental BiologyThe ubiquitin proteasome system maintains protein homeostasis by regulating the breakdown of misfolded proteins, thereby preventing misfolded protein aggregates. The efficient elimination is vital for preventing damage to the cell by misfolded proteins, known as proteotoxic stress.
Rachel Kandel, Sonya E Neal
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Ubiquitin–Proteasome System and mitochondria — Reciprocity
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2011Recently, sporadic links have been published between mitochondria - membrane-confined organelles - and the cytosolic ubiquitin-proteasome system (UPS) for removal of cellular proteins. For example, Fzo1, a mitochondrial outer membrane mitofusin was shown to be ubiquitinated by a ubiquitin ligase, Cdc53(MDM30), and degraded by the proteasome.
Nurit, Livnat-Levanon +1 more
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The role of ubiquitin–proteasome system in ageing
General and Comparative Endocrinology, 2011Maintenance of cellular homeostasis influences ageing and it is determined by several factors, including efficient proteolysis of damaged proteins. The ubiquitin-proteasome system is the major protein degradation pathway in the cell. Specifically, the proteasome is responsible for clearance of abnormal, denatured or in general damaged proteins as well ...
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Transgenic manipulation of the ubiquitin–proteasome system
Essays in Biochemistry, 2005The transgenic approach has been used in model systems from yeast to mammals to address basic research questions, and to achieve agricultural, pharmaceutical or industrial objectives. In basic research, transgenic organisms have generated novel observations that could not have been obtained otherwise. This chapter concentrates on the use of transgenics
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The Ubiquitin–Proteasome System Links NADPH Metabolism to Ferroptosis
Trends in Cell Biology, 2023Cheol-Sang Hwang +2 more
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