Results 241 to 250 of about 164,141 (292)

Commentary: The ubiquitin-proteasome system in the tumor immune microenvironment: a key force in combination therapy. [PDF]

Front Immunol
Zhang L, Jia L, Wang L, Yuan W, Shi X.
europepmc   +1 more source

The ribosome‐associated complex regulates cytosolic translation upon mitoprotein‐induced stress

The FEBS Journal, EarlyView.
Defects in mitochondrial protein import trigger a stress response. The contribution of translation regulation to such a response is only partially understood. We demonstrate that the deletion of mitochondrial surface proteins (TOM70/TOM71) leads to defects in mitochondrial biogenesis and slow growth.
Jiaxin Qian, Annika Nutz, Katja Hansen, Lea Bertgen, Mirita Franz‐Wachtel, Boris Macek, Johannes M. Herrmann, Doron Rapaport   +7 more
wiley   +1 more source

The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders. [PDF]

Neurosci Bull
Liu X, Wang W, Nie Q, Liu X, Sun L, Ma Q, Zhang J, Wei Y.   +7 more
europepmc   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Ubiquitin-proteasome system dysregulation in FAM111B-related poikiloderma and phenotypic spectrum expansion: new case reports and long-term follow-up. [PDF]

EBioMedicine
Vignard V, Maillasson M, Bigot A, Küry S, Besnard T, Broly M, Guého A, Com E, Davis E, Deb W, Florenceau L, Sobriel K, Ménard G, Gardie B, Goldenberg A, Porrmann J, Richardson R, Ruffier L, Hadj-Rabia S, Bézieau S, Barbarot S, Ebstein F, Mercier S.   +22 more
europepmc   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

Interferon-induced PARP14-mediated ADP-ribosylation in p62 bodies requires the ubiquitin-proteasome system. [PDF]

EMBO J
Raja R, Biswas B, Abraham R, Wang Y, Chang CY, Hendriks IA, Buch-Larsen SC, Liu H, Yang X, Wang C, Vu H, Hamacher-Brady A, Cai D, Leung AKL.   +13 more
europepmc   +1 more source

NDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration. [PDF]

Mol Brain
Hoshino T, Mukai A, Yamashita H, Misawa H, Urushitani M, Tashiro Y, Matsuzawa SI, Takahashi R.   +7 more
europepmc   +1 more source

Targeting the ubiquitin-proteasome system: a novel therapeutic strategy for neuroblastoma. [PDF]

Front Oncol
He Y, Wang J, Xiao T.
europepmc   +1 more source

Regulation of ubiquitin-proteasome system and its relative pathways in pancreatic adenocarcinoma. [PDF]

Bioimpacts
Shateri Amiri B, Naserranjbar M, Mirhaji A, Hejrati A, Hejrati L, Aliabadi F.   +5 more
europepmc   +1 more source