Results 231 to 240 of about 18,434,088 (294)

Benchmarking In-Cell Proteomics for Profiling Neuroblastoma Cell Differentiation and the Ubiquitin-Proteasome System. [PDF]

J Proteome Res
Moafian Z, Marino MJ, Yu Y, Zhuang Z.
europepmc   +1 more source

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source

Dysregulation of the ubiquitin-proteasome system in von Hippel-Lindau syndrome: molecular insights and clinical perspectives. [PDF]

Clin Exp Med
Bi Y, Wang R, Li L, Wang L, Chen X, Nie X, Meng J, Cai S.   +7 more
europepmc   +1 more source

Lactylation of HSC70 Impairs Chaperone‐Mediated Autophagy to Promote Pyrin Inflammasome‐Dependent PANoptosis in Macrophages During Sepsis

Advanced Science, EarlyView.
In sepsis, lactate accumulation drives HSC70 K561 lactylation, which impairs chaperone‐mediated autophagy and blocks CUX1 degradation. Accumulated CUX1 transcriptionally upregulates Pyrin, triggering PANoptosis in macrophages and exacerbating inflammatory storm and organ injury.
Ying Chen, Yan Zhang, Pei Wang, Jiamin Ma, Xinru Zhao, Yi Li, Zhenghao Deng, Xueqing Meng, Jiali Zhu, Liangfang Yao, Jinbao Li   +10 more
wiley   +1 more source

Ubiquitin Proteasome System Components, RAD23A and USP13, Modulate TDP-43 Solubility and Neuronal Toxicity. [PDF]

J Neurosci
Dalton C, Mojsilovic-Petrovic J, Safren N, Snoznik C, Gebis KK, Wang YZ, Sutter AB, Lamitina T, Savas JN, Kalb RG.   +9 more
europepmc   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source

The ubiquitin-proteasome system: A potential target for the MASLD. [PDF]

Acta Pharm Sin B
Liu Y, Qian M, Li Y, Dong X, Wu Y, Yuan T, Ma J, Yang B, Zhu H, He Q.   +9 more
europepmc   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +1 more source

The transcription factor ANAC017 links mitochondrial retrograde signaling with the ubiquitin-proteasome system to control mitochondrial function in Arabidopsis. [PDF]

Plant Commun
Zhao Y, Ogden M, Pan R, Hu J, Persson S, Murcha MW, Shou H, Wang Y, Khan GA, Whelan J.   +9 more
europepmc   +1 more source

Ein Ruthenium(CAAC‐5)‐Olefin‐Metathese‐Katalysator für die Biokonjugation

Angewandte Chemie, EarlyView.
Die Instabilität von Rutheniumkatalysatoren in wässrigen Lösungen schränkt die Olefinmetathese in biologischen Medien ein. Es wird über einen Ru(CAAC‐5)‐Komplex berichtet, der unter biologisch relevanten Bedingungen aktiv bleibt und die Biokonjugation mit Proteinen, Peptiden und einem künstlichen Metalloenzym ermöglicht.
Damian Alexander Graf, Mikhail Boym, María Álvarez, Tsvetan Kardashliev, Thomas R. Ward   +4 more
wiley   +1 more source