Results 111 to 120 of about 7,340,584 (263)

MAM‐Localized MANF Counteracts Microinflammatory Stress to Attenuate Mitochondrial Dysfunction and Cataractogenesis in High Myopia

Advanced Science, EarlyView.
Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu, Hao Li, Ching Kang, Dongling Guo, Shuyu Liu, Jiaqi Meng, Zhiqian Huang, Yu Du, Xiangjia Zhu   +8 more
wiley   +1 more source

Regulation of SCF Ubiquitin Ligases by Jab1/Csn5 and the Cop9 Signalosome [PDF]

, 2006
SCF ubiquitin ligases regulate the ubiquitin-dependent proteolysis of a myriad of substrate proteins, including p27, Cyclin E, and IkBa. To further gain insight into SCF regulation and function, we purified SCF from mammalian cells and found the Cop9 ...
Cope, Gregory Allan
core   +1 more source

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Expression of yeast deubiquitination enzyme UBP1 analogues in E. coli

Microbial Cell Factories, 2005
Background It has been shown that proteins fused to ubiquitin undergo greater expression in E. coli and are easier to purify and renaturate than nonhybrid foreign proteins.
Chojnacka Luiza, Mikiewicz-Sygula Diana, Plucienniczak Grazyna, Mazurkiewicz-Pisarek Anna, Wojtowicz Anna, Lukasiewicz Natalia, Plucienniczak Andrzej   +6 more
doaj   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

Role of SUMO-1 modification in transcriptional activation [PDF]

, 2012
In unstimulated cells, the transcription factor NF-κB is held in the cytoplasm in an inactive state by IκB inhibitor proteins. Activation of NF--KB is mediated by signal induced degradation of IκBα via the ubiquitin proteasome-dependent pathway ...
Pinto Desterro, Maria Joana
core   +1 more source

Transcriptional Profile and Structural Conservation of SUMO-Specific Proteases in Schistosoma mansoni

Journal of Parasitology Research, 2012
Small ubiquitin-related modifier (SUMO) is involved in numerous cellular processes including protein localization, transcription, and cell cycle control.
Roberta Verciano Pereira, Fernanda Janku Cabral, Matheus de Souza Gomes, Liana Konovaloff Jannotti-Passos, William Castro-Borges, Renata Guerra-Sá   +5 more
doaj   +1 more source

Distinct ubiquitin binding modes exhibited by SH3 domains: Molecular determinants and functional implications [PDF]

, 2013
SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation.
Jerónimo Bravo (22727), Jose L Ortega Roldan, Jerónimo Bravo, Ana I. Azuaga, Casares Atienza, Salvador, Ringkjøbing Jensen, M, van Nuland, Nico A. J., Azuaga, AI, Malene Ringkjøbing Jensen, Buday, Laszlo, Azuaga, Ana I., Ortega Roldan, Jose L., Martin Blackledge, van Nuland, Nico a J, Martin Blackledge (204261), Cárdenes, N, Nuland, Nico A. J. van, Blackledge, M, Ringkjøbing Jensen, Malene, Azuaga, Ana I, Casares, S, Salvador Casares (69741), Jensen, Malene Ringkjøbing, Ortega-Roldán, José Luis, Casares, Salvador, Nico A. J. van Nuland (116707), Bravo, J, Ortega Roldan, Jose L, Van Nuland, NAJ, Bravo, Jerónimo, Jose L. Ortega Roldan (457421), Azuaga Fortes, Ana Isabel, Ana I. Azuaga (121437), Ortega-Roldan, Jose L., Nico A J van Nuland, Jose L. Ortega Roldan, Malene Ringkjøbing Jensen (204257), Nayra Cárdenes (457422), Cárdenes, Nayra, Nico A. J. Van Nul, Ana I Azuaga, Salvador Casares, Ortega Roldan, JL, Nayra Cárdenes, Blackledge, Martin   +44 more
core   +1 more source

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Unraveling the Mechanism of Action of Ubiquitin-Specific Protease 5 and Its Inhibitors in Tumors

Clinical Medicine Insights: Oncology
Ubiquitin-specific protease 5 (USP5), a member of the ubiquitin-specific proteases (USPs) family, functions by specifically removing ubiquitin chains from target proteins for stabilization and degrading unbound polyubiquitin chains to maintain a steady ...
Jie Wang, Shizhen Fang, Yang Jiang, Qingquan Hua   +3 more
doaj   +1 more source