Results 181 to 190 of about 33,030 (228)
The E3 ligase β-TRCP1 earmarks OTUD3 for destruction to fine-tune cGAS activation. [PDF]
J Biol ChemChen J, Sivashankar S, Wang Y, Liu P.
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Ubiquitin-Specific Proteases as Cancer Drug Targets
Future Oncology, 2011Ubiquitin-specific proteases are deubiquitinating enzymes involved in the removal of ubiquitin from specific protein substrates resulting in protein salvage from proteasome degradation, regulation of protein localization or activation. DNA alteration and overexpression in different cancer types, as well as involvement in many cancer-associated pathways,
Wolfgang Sippl, Frédéric Colland
exaly +3 more sources
Targeting ubiquitin specific proteases for drug discovery
Biochimie, 2008Deregulation of the ubiquitin-proteasome system has been implicated in the pathogenesis of many human diseases, including cancer, neurodegenerative disorders and viral diseases. The recent approval of the proteasome inhibitor bortezomib (Velcade) for the treatment of multiple myeloma and mantle cell lymphoma establishes this system as a valid target ...
Laurent Daviet, Frédéric Colland
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Activation Dynamics of Ubiquitin Specific Protease 7
2023ABSTRACT Ubiquitin-specific protease 7 (USP7) is a deubiquitinating enzyme responsible for the regulation of key human oncoproteins and tumor suppressors including Mdm2 and p53, respectively. Unlike other members of the USP family of proteases, the isolated catalytic domain of USP7 adopts an enzymatically inactive conformation that has ...
Gabrielle J. Valles +3 more
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The role of UBL domains in ubiquitin-specific proteases
Biochemical Society Transactions, 2012Ubiquitin conjugation and deconjugation provides a powerful signalling system to change the fate of its target enzymes. Ubiquitination levels are organized through a balance between ubiquitinating E1, E2 and E3 enzymes and deubiquitination by DUBs (deubiquitinating enzymes). These enzymes are tightly regulated to control their activity.
Alex C. Faesen +2 more
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Biochemical Pharmacology
Depression is one of the most common and debilitating mental disorders and one of the main causes of disability worldwide. Despite the progress made in the treatment of depression, approximately 20 %-40 % of patients with a major depressive episode do not show a clinical response to current antidepressant treatments. Approximately 85 % of patients with
Wei Guan
exaly +3 more sources
Depression is one of the most common and debilitating mental disorders and one of the main causes of disability worldwide. Despite the progress made in the treatment of depression, approximately 20 %-40 % of patients with a major depressive episode do not show a clinical response to current antidepressant treatments. Approximately 85 % of patients with
Wei Guan
exaly +3 more sources
UBP41 is a proapoptotic ubiquitin-specific protease.
Cancer research, 2003We have isolated Ubp41, a ubiquitin-specific protease, in a screen for proapoptoticgenes. We found that overexpression of Ubp41 is sufficient to elicit all features of apoptosis in human cells. In contrast, an enzymatically defective UBP41 mutant and homologous ubiquitin-processing protease family members did not significantly induce cell death ...
Gewies, A., Grimm, S.
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Exploring Ubiquitin-specific proteases as therapeutic targets in Glioblastoma
Pathology Research and PracticeGlioblastoma (GB) remains a formidable challenge and requires new treatment strategies. The vital part of the Ubiquitin-proteasome system (UPS) in cellular regulation has positioned it as a potentially crucial target in GB treatment, given its dysregulation oncolines.
Ehssan Moglad, Vijaya Paul Samuel
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The ubiquitin-specific protease USP28 is required for MYC stability
Nature Cell Biology, 2007The MYC proto-oncogene encodes a transcription factor that has been implicated in the genesis of many human tumours. Here, we used a bar-code short hairpin RNA (shRNA) screen to identify multiple genes that are required for MYC function. One of these genes encodes USP28, an ubiquitin-specific protease.
Nikita, Popov +8 more
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