Results 71 to 80 of about 7,340,584 (263)

The molecular basis for ubiquitin and ubiquitin-like specificities in bacterial effector proteases [PDF]

, 2016
Pathogenic bacteria rely on secreted effector proteins to manipulate host signaling pathways, often in creative ways. CE clan proteases, specific hydrolases for ubiquitin-like modifications (SUMO and NEDD8) in eukaryotes, reportedly serve as bacterial ...
Durkin, CH, Geurink, PP, Holden, DW, Pruneda, JN, Ovaa, H, Komander, D, Santhanam, B   +6 more
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs

Frontiers in Molecular Biosciences, 2021
Ubiquitin is a small protein at the heart of many cellular processes, and several different protein domains are known to recognize and bind ubiquitin. A common motif for interaction with ubiquitin is the Ubiquitin Interacting Motif (UIM), characterized ...
Matteo Lambrughi, Matteo Lambrughi, Emiliano Maiani, Burcu Aykac Fas, Gary S. Shaw, Birthe B. Kragelund, Kresten Lindorff-Larsen, Kaare Teilum, Gaetano Invernizzi, Elena Papaleo, Elena Papaleo   +10 more
doaj   +1 more source

Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]

, 2014
Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Viral deubiquitinating proteases and the promising strategies of their inhibition

Virus Research
Several viruses are now known to code for deubiquitinating proteases in their genomes. Ubiquitination is an essential post-translational modification of cellular substrates involved in many processes in the cell, including in innate immune signalling ...
Vera J.E. van Vliet, Anuradha De Silva, Brian L. Mark, Marjolein Kikkert   +3 more
doaj   +1 more source

Spotlights on ubiquitin-specific protease 12 (USP12) in diseases: from multifaceted roles to pathophysiological mechanisms

Journal of Translational Medicine, 2023
Ubiquitination is one of the most significant post-translational modifications that regulate almost all physiological processes like cell proliferation, autophagy, apoptosis, and cell cycle progression.
Kaiyi Niu, Yanlong Shi, Qingpeng Lv, Yizhu Wang, Jiping Chen, Wenning Zhang, Kung Feng, Yewei Zhang   +7 more
doaj   +1 more source

Epstein-Barr Virus Encodes Three Bona Fide Ubiquitin-Specific Proteases [PDF]

, 2008
Manipulation of the ubiquitin proteasome system (UPS) is emerging as a common theme in viral pathogenesis. Some viruses have been shown to encode functional homologs of UPS enzymes, suggesting that a systematic identification of these products may ...
Masucci, Maria G,, Gastaldello, Stefano, Hassink, Gerco, Haas, Juergen, Haas, Jürgen, Persson, Bengt, Lindsten, Kristina,, Hassink, Gerco,, Sompallae, Ramakrishna, Masucci, Maria G., Sompallae, Ramakrishna,, Gastadello, Stefano, Hildebrand, Sebastian,, Hildebrand, Sebastian, Persson, Bengt,, Zinin, Nikolay, Lindsten, Kristina, Zinin, Nikolay,   +17 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

The ubiquitin-specific protease USP8 deubiquitinates and stabilizes Cx43 [PDF]

Journal of Biological Chemistry, 2018
Connexin-43 (Cx43, also known as GJA1) is the most ubiquitously expressed connexin isoform in mammalian tissues. It forms intercellular gap junction (GJ) channels, enabling adjacent cells to communicate both electrically and metabolically. Cx43 is a short-lived protein which can be quickly degraded by the ubiquitin-dependent proteasomal, endolysosomal,
Jian, Sun, Qianwen, Hu, Hong, Peng, Cheng, Peng, Liheng, Zhou, Jinsong, Lu, Chuanxin, Huang   +6 more
openaire   +2 more sources