Results 141 to 150 of about 7,309,904 (153)

Characterization of the Ubiquitin Specific Protease (USP) family members in the fast and slow muscle fibers from Chinese perch (Siniperca chuatsi)

Gene, 2018
Skeletal muscle atrophy results from fasting, disuse and other systemic diseases. Muscle atrophy is associated with increased muscle protein degradation via the Ubiquitin proteasome system (UPS). The Ubiquitin Specific Proteases (USPs), also known as deubiquitinating enzymes, regulates a wide variety of cellular processes in skeletal muscle.
FangLiang, Zhang, YuLong, Li, Lin, Chen, Jia, Cheng, Ping, Wu, WuYing, Chu, JianShe, Zhang   +6 more
openaire   +2 more sources

The role of ubiquitin‐specific protease 14 (USP14) in cell adhesion‐mediated drug resistance (CAM‐DR) of multiple myeloma cells

European Journal of Haematology, 2016
AbstractObjectiveCell adhesion‐mediated drug resistance (CAM‐DR) is one of the mechanisms underlying the drug resistance in multiple myeloma (MM). Ubiquitin‐specific protease 14 (USP14) is downregulated in the apoptotic model and upregulated in the adhesive model of MM.
Xiaohong, Xu, Jing, Liu, Chaoyan, Shen, Linlin, Ding, Fei, Zhong, Yu, Ouyang, Yuchan, Wang, Song, He   +7 more
openaire   +2 more sources

A ubiquitin specific protease (USP) network regulates wnt/β-catenin activity in myeloid leukemia cells

Blood
Abstract Canonical Wnt signalling is an important regulator of haematopoietic stem/progenitor cells (HSPC) and frequently dysregulated in myeloid neoplasms. Overexpression, overactivity or mislocalisation of the central mediator β-catenin has been reported in multiple acute myeloid leukaemia ...
Megan Wagstaff, Okan Sevim, Maddie Harrison, Brandon Coke, Allison Blair, Timothy Chevassut, Ethan Morgan, Rhys Morgan   +7 more
openaire   +1 more source

Abstract 3665: Insilco evaluation of multiple ubiquitin-specific protease 1 (USP1) inhibitors and selectivity profiling over other USPs using Alphafold

Cancer Research
Abstract DNA damage triggers cell signaling cascades that mediate repair. This signaling is frequently dysregulated in cancers. The proteins that mediate this signaling are potential targets for therapeutic intervention. Ubiquitin-specific protease 1 (USP1) is one such target, with small-molecule inhibitors already in clinical trials ...
Prashant Kashinath Bhavar, Uday Kumar Surampudi, Appaji Baburao Mandhare, Rupesh Chikhale   +3 more
openaire   +1 more source

Ubiquitin-specific proteases: Vital regulatory molecules in bone and bone-related diseases

International Immunopharmacology, 2023
Yingying Wu, Yi Xiong, Wenxin Luo
exaly  

Faculty Opinions recommendation of An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2016
openaire   +1 more source

Targeting ubiquitin specific proteases for drug discovery

Biochimie, 2008
Laurent Daviet
exaly  

Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics

Breast Cancer Research and Treatment, 2006
Hongying Zhou, Shishan Deng
exaly  

Ubiquitin-specific proteases as targets for anticancer drug therapies

2020
Carlos Lopez-Otin, José M P Freije, Diana Campos-Iglesias   +2 more
exaly  

Function and regulation of SUMO proteases

Nature Reviews Molecular Cell Biology, 2012
Mark Hochstrasser, Christopher M Hickey
exaly