Results 251 to 260 of about 519,123 (352)

RNF114, a RING E3 ligase that reads and extends the hybrid ADP-ribose-ubiquitin signal. [PDF]

EMBO J
Middleton AJ, Day CL.
europepmc   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

MARCH2-mediated Lys63-linked polyubiquitination promotes metastasis by modulating the catalytic activity of TGF-β type I receptor. [PDF]

Cell Death Dis
Tae K, Cho SW, Lee S, Heo D, Cha HS, Lee DY, Oh E, Choi M, Shin D, Yang S, Lee C, Choi CY.   +11 more
europepmc   +1 more source

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, EarlyView.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source

Mechanistic basis for the opposing effects of H2A and H2B ubiquitination on nucleosome stability and dynamics. [PDF]

Epigenetics Chromatin
Baweja L, Wereszczynski J.
europepmc   +1 more source

UBE2S drives elongation of K11-linked ubiquitin chains by the Anaphase-Promoting Complex

, 2010
Tao Wu, Yifat Merbl, Ying Huo, Jennifer L. Gallop, Amit Tzur, Marc W. Kirschner   +5 more
openalex   +1 more source

The Genetic Wiring of Plant Trichomes: From Initiation to Fate Specification

Advanced Science, EarlyView.
Plant trichomes are not just simple hairs but metabolic powerhouses shaped by complex genetic programs. While the MYB‐bHLH‐WD40 module is well studied in Arabidopsis, recent findings reveal that HD‐Zip IV transcription factors drive multicellular and glandular trichome development through dose‐dependent mechanisms.
Meng Li, Yuanbo Huang, Yadi Du, Shuang Wu   +3 more
wiley   +1 more source

Evolutionary conservation of ubiquitin-like protein urmylation as revealed by URM1 gene shuffle from archaea to yeast. [PDF]

Commun Biol
Zupfer K, Kaduhr L, Bessler L, Helm M, Schaffrath R.   +4 more
europepmc   +1 more source

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

Advanced Science, EarlyView.
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang, Xiaoyu Chen, Shengpeng Shao, Xue Liang, Jun Xu, Yi Sun, Xiufang Xiong, Yongchao Zhao   +10 more
wiley   +1 more source

The Ubiquitin-Proteasome System in Hepatitis B Virus Infection and Hepatocarcinogenesis: Viral Manipulation and Therapeutic Targets. [PDF]

J Microbiol Biotechnol
Han J, Kim KH, Seo SU.
europepmc   +1 more source