Results 251 to 260 of about 574,104 (383)
Spatiotemporal Supra‐LYTAC formation near cancerous membrane via CAIX‐targeting is achieved. As a result of generation of Supra‐LYTAC, POI trafficking into lysosome is significantly implemented for targeted protein degradation. Abstract Recently, targeted protein degradation (TPD) strategies have emerged as a promising solution to tackle undruggable ...
Dohyun Kim+6 more
wiley +1 more source
Auto-ubiquitination of ubiquitin-activating enzymes from chicken breast muscle [PDF]
J.E. Arnold, Wieland Gevers
openalex +1 more source
Ubiquitin-proteasome system in the different stages of dominantly inherited Alzheimer's disease. [PDF]
Liu H+36 more
europepmc +1 more source
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang+13 more
wiley +1 more source
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu+20 more
wiley +1 more source
Purification and characterization of a ubiquitin carrier protein kinase from HeLa cells. [PDF]
S. K. Kong, P Boon Chock
openalex +1 more source
Regulatory Roles of E3 Ubiquitin Ligases and Deubiquitinases in Bone. [PDF]
He H, Wang L, Xian B, Xia Y.
europepmc +1 more source
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong+9 more
wiley +1 more source
Ubiquitin-conjugating enzyme UBE2N modulates proteostasis in immunoproteasome-positive acute myeloid leukemia. [PDF]
Ishikawa C+12 more
europepmc +1 more source