Results 261 to 270 of about 596,162 (342)

GLS1 Orchestrates Exosome‐Mediated Tumor‐Endothelial Communication to Facilitate Angiogenesis

Advanced Science, EarlyView.
This study reveals a previously unappreciated, non‐metabolic function of GLS1 in the control of tumor angiogenesis via exosome‐mediated CAV1‐TNC signaling, indicating that therapeutic targeting of GLS1 may offer a dual benefit by simultaneously suppressing tumor metabolic activity and angiogenic processes in head and neck cancer. ABSTRACT Glutaminase 1
Jianqiang Yang, Zhenzhen Fu, Fanghui Chen, Soumya Vijaya Kumar, Fan Yang, Yaochao Zheng, Yunqi Li, Yao Yao, Nabil F. Saba, Yong Teng   +9 more
wiley   +1 more source

Mitophagy in bladder cancer: a double-edged sword in tumor progression and therapy. [PDF]

J Transl Med
Chen Q, Chen T, Gan L, Lu Y, Qian B.
europepmc   +1 more source

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Ubiquitin-Mediated Proteolysis as a Regulator of the Plant Defense-Growth Balance. [PDF]

Plants (Basel)
Gonçalves MF, Carneiro AK, Otero RM, Hemerly AS.   +3 more
europepmc   +1 more source

The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi‐Morbidity

AGING MEDICINE, EarlyView.
Exosomes transporting miRNAs play a crucial bidirectional regulatory role in the process of sarcopenia, both in natural aging and under various pathological conditions. ABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease ...
Bingyu Huang, Zhao Peng, Lin Kang
wiley   +1 more source

Correction for Jaen Maisonet et al., Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7). [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

HOS1-mediated both ubiquitination and nuclear-import are crucial to nitrate signaling. [PDF]

Front Mol Biosci
Xie LB, Yang XY, Zhang ZW, Tang XY, Yuan S.   +4 more
europepmc   +1 more source

USP10 deubiquitinase: Physiological function, diseases and therapeutic target (Review). [PDF]

Int J Mol Med
Zhang L, Sun H, Wang Z, Wang Z, Mu Q, Liu Y.   +5 more
europepmc   +1 more source

Cis or trans: a puzzle of Parkin activation mechanism. [PDF]

Essays Biochem
Sherawat M, Kumar A, Lenka DR, Kumar A.
europepmc   +1 more source

Novel Therapeutic Targets of Endothelial Inflammation in Acute Lung Injury and Acute Respiratory Distress Syndrome. [PDF]

J Respir Biol Transl Med
Su Y.
europepmc   +1 more source