Results 261 to 270 of about 353,107 (313)

Protein Modifications and Quality Control System: Target for Alzheimer's Disease Therapy. [PDF]

Int J Mol Sci
Sheikh AM, Yano S, Tabassum S, Bhuiya J, Nagai A.   +4 more
europepmc   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

K63-linked ubiquitylation of S2P-RNAPII regulates transcription in a DNAPK inter-dependent manner in response to double-strand breaks. [PDF]

Nucleic Acids Res
Pantazi V, Smith P, Pahi ZG, Katona M, Pap A, Darula Z, Fischer R, Vendrell I, Kessler BM, van Vugt MATM, D'Angiolella V, Pankotai T.   +11 more
europepmc   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source

Cosolutes Modulate Polyubiquitin Fibrillation. [PDF]

ACS Omega
Acharya K, Ainavarapu SRK, Das R.
europepmc   +1 more source

Post-translational modifications as a regulatory code for tau function in health and disease. [PDF]

Front Dement
Nordbeck AJ, Sharma B, Garcia CA, Tseng JH.   +3 more
europepmc   +1 more source

E3 ubiquitin ligase RNF40: Structure, function and its context‑dependent roles in tumorigenesis (Review). [PDF]

Oncol Rep
Wu Z, Yang H, Chen G, Zhao W, Bao B, Luv C, Zhu W, Liu F, Ai H, Li Z.   +9 more
europepmc   +1 more source

Ubiquitin E3 ligase MYCBP2 targets KIF14 and contributes to acute myeloid leukemia progression. [PDF]

J Biol Chem
Yao G, Yang Y, Chen C, Zheng B, Qiu T, Yang L, Hu M.   +6 more
europepmc   +1 more source

Polyglutamine-Expanded Ataxin-3 Accelerates CFTR Degradation Through K63-Linked Ubiquitination to Exacerbate Microglial Inflammation. [PDF]

ASN Neuro
Wang Z, Fan X, Bai B, Song M, Shi Y, Zhao Y, Xie P, Shi T, He C, Hu Y, Wu Q, Hou X.   +11 more
europepmc   +1 more source

Porcine Reproductive and Respiratory Syndrome Virus NSP8 Suppresses NF-κB Signaling by Hijacking Host UBE2K and IKKα. [PDF]

Viruses
Liu D, Yan Y, Fu X, Qin L, Ma J, Zhou H, Sun S, Li H, Dong W, Zhou J.   +9 more
europepmc   +1 more source