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Modification of Proteins by Ubiquitin and Ubiquitin-Like Proteins
Annual Review of Cell and Developmental Biology, 2006Following the discovery of protein modification by the small, highly conserved ubiquitin polypeptide, a number of distinct ubiquitin-like proteins (Ubls) have been found to function as protein modifiers as well. These Ubls, which include SUMO, ISG15, Nedd8, and Atg8, function as critical regulators of many cellular processes, including transcription ...
Oliver, Kerscher +2 more
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Targeting the monocytic ubiquitin system with extracellular ubiquitin
Immunology & Cell Biology, 2006Recent findings suggest that extracellular ubiquitin has pleiotropic effects on host defence mechanisms, but its cellular mechanism of action is not yet understood. Using fluorescence and in vivo confocal microscopy, we observed uptake of N‐terminal fluorescein‐labelled ubiquitin into human PBMC and MonoMac 6 cells. Immunoblotting experiments indicated
Matthias, Majetschak +2 more
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Ubiquitin adenylate: structure and role in ubiquitin activation
Biochemistry, 1983The acid precipitate of the ubiquitin activating enzyme after reaction with ATP and ubiquitin contains one enzyme equivalent of ubiquitin adenylate in which the carboxyl-terminal glycine of ubiquitin and AMP are in an acyl-phosphate linkage. The recovered ubiquitin adenylate has the catalytic properties proposed for it as a reaction intermediate. Thus,
A L, Haas, J V, Warms, I A, Rose
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A ubiquitin and ubiquitin‐like protein spectral library
PROTEOMICS, 2010AbstractWe have developed and validated a ubiquitin (Ub) and ubiquitin‐like protein (Ubl) spectral library, consisting of 467 consensus spectra (320 unique peptides derived from autophagy‐related protein 8, F‐adjacent transcript 10, interferon‐stimulated gene 15 kDa protein, neural precursor cell expressed developmentally down‐regulated protein 8 ...
Srikumar, Tharan +3 more
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Structural insights into the catalysis and regulation of E3 ubiquitin ligases
Nature Reviews Molecular Cell Biology, 2016Danny T Huang, Lori Buetow
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Building and decoding ubiquitin chains for mitophagy
Nature Reviews Molecular Cell Biology, 2018Jin-Mi Heo +2 more
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