Results 281 to 290 of about 574,104 (383)

PIP5K1A Suppresses Ferroptosis and Induces Sorafenib Resistance by Stabilizing NRF2 in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
Inducing ferroptosis is a promising strategy for combating tumor resistance. Upregulated PIP5K1A competes with NRF2 for KEAP1 binding, which decreases the ubiquitination degradation of NRF2 and promotes its nuclear translocation, thereby suppressing ferroptosis, and ultimately driving hepatocellular carcinoma (HCC) tumorigeneses and sorafenib ...
Mengzhou Guo   +9 more
wiley   +1 more source

TRIM22 promotes glioblastoma development by ubiquitinating Bcl-2. [PDF]

open access: yesMol Cell Oncol
Zhang J   +8 more
europepmc   +1 more source

K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2018
F. Ohtake   +3 more
semanticscholar   +1 more source

MdDSK2a‐Like‐MdMTA Module Functions in Apple Cold Response via Regulating ROS Detoxification and Cell Wall Deposition

open access: yesAdvanced Science, EarlyView.
Under cold stress, MdDSK2a‐like is degraded via the 26S proteasome pathway, thereby alleviating the degradation of MdMTA induced by the 26S proteasome and autophagy pathways mediated by MdDSK2a‐like. The accumulated MdMTA increases the m6A levels of cold‐responsive genes, thereby contributing to increased ROS detoxification, deposition of cell wall, as
Nan Hou   +18 more
wiley   +1 more source

Ubiquitin ligases in oncogenic transformation and cancer therapy

open access: yesNature Reviews. Cancer, 2017
D. Senft, Jianfei Qi, Z. Ronai
semanticscholar   +1 more source

Single‐Cell Transcriptome Reveals Aquaporin‐Mediated Carbon Nanosol‐Induced Growth Promotion of Plants

open access: yesAdvanced Science, EarlyView.
Carbon nanosol (CNS) exhibits rapid root penetration capacity, enhancing plant growth through boosting stomatal density and antioxidative enzyme activity. Single‐cell transcriptomic profiling uncovers cell type‐specific gene expression patterns and developmental trajectories during CNS‐mediated growth promotion.
Lingtong Cheng   +10 more
wiley   +1 more source

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