Results 281 to 290 of about 525,256 (308)

Phocaeicola coprophilus‐Derived 6‐Methyluracil Attenuates Radiation‐Induced Intestinal Fibrosis by Suppressing the IDO1‐Kynurenine‐AHR Axis

Advanced Science, EarlyView.
IR‐induced dysbiosis depletes P. coprophilus and its metabolite 6‐methyluracil, leading to disinhibition of the IDO1‐Kyn‐AHR axis. This results in sustained fibroblast activation and collagen deposition, driving radiation induced intestinal fibrosis. ABSTRACT Therapeutic options for radiation‐induced intestinal fibrosis (RIF) remain limited. This study
Jiaxin Zhang, Zhen Wang, Shuang Li, Chao Luo, Han Li, Shengjie Ma, Pai Wang, Heshi Liu, Lijun Sun, Yue Yin, Weizhen Zhang, Quan Wang   +11 more
wiley   +1 more source

DNA double strand break repair: a model of specificity and complexity in SUMO signalling. [PDF]

Essays Biochem
Bhachoo JS, Garvin AJ.
europepmc   +1 more source

Regulation of the microprocessor by post-translational modifications. [PDF]

Front Cell Dev Biol
Leong KW, Chong MMW.
europepmc   +1 more source

Identification and characterization of a ubiquitin E3 RING ligase of the Chlamydia-like bacterium Simkania negevensis. [PDF]

PLoS Pathog
Hörner EM, Lachmayer V, Hermanns T, Moldovan A, Hofmann K, Kozjak-Pavlovic V.   +5 more
europepmc   +1 more source

Non-Histone Lysine Modifications in Tumor Microenvironment: Mechanisms and Therapeutic Opportunities. [PDF]

Int J Mol Sci
Sun K, Xiao S, Huang Q, Zhang S, Li Q, Hu C.   +5 more
europepmc   +1 more source

Discovery andOptimizationof Novel Tricyclic Ubiquitin-SpecificProtease 1 Inhibitors for the Treatment of BRCA-Mutated Breast Cancer

Tianning Xiong (16639670), Hong Yang (37298), Songwen Lin (1622227), Li Sheng (118074), Junpu Ge (21548152), Jinhua Wang (1506), Heng Xu (244639)   +6 more
openalex   +1 more source

Harnessing Ubiquitin-Proteasome System-Related Genes to Identify Subtypes of Bladder Cancer and Reveal Immune Landscape. [PDF]

Am J Mens Health
Shi G, Zhou X, Yang F, Wang T.
europepmc   +1 more source

The Interplay Between the Ubiquitin-Proteasome System and Oxidative Stress: A Future Perspective in Eye Diseases. [PDF]

Antioxidants (Basel)
Tundo GR, Zingale GA, Pandino I, Peroni E, Sbardella D, Bocedi A.   +5 more
europepmc   +1 more source

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An expanded lexicon for the ubiquitin code

Nature Reviews Molecular Cell Biology, 2022
Ivan Đikić, Brenda A Schulman
exaly  

Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism

Chemical Reviews, 2018
Laurent Cappadocia, Christopher D Lima
exaly