Results 281 to 290 of about 519,123 (352)

The deubiquitinating enzyme Cezanne stabilizes BRCA1 by counteracting APC/C and Ube2S-dependent Lys11-linked ubiquitination. [PDF]

PLoS Biol
Wang L, Wu X, Paul A, Yao J, Wang B.
europepmc   +1 more source

ZDHHC2‐Dependent Palmitoylation Dictates Ferroptosis and Castration Sensitivity in Prostate Cancer via Controlling ACSL4 Degradation and Lipid Peroxidation

Advanced Science, EarlyView.
Our study reveals a novel mechanism by which palmitoylation regulates ferroptosis and enzalutamide resistance in prostate cancer. Under enzalutamide resistance, the FOXA1/CXXC5/TET2 complex induces aberrant upregulation of ZDHHC2, which subsequently suppresses ferroptosis by mediating S‐palmitoylation of USP19 and degradation of ACSL4 protein in CRPC ...
Shuai Shao, Wei Li, Yulong Hong, Ruijiang Zeng, Liang Zhu, Lu Yi, Yuan Li, Yinhuai Wang, Haojie Huang, Xuewen Jiang, Xin Jin   +10 more
wiley   +1 more source

Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size. [PDF]

Am J Physiol Cell Physiol
Baehr LM, Oliveira de Sousa LG, Goodman CA, Sharples AP, Waddell DS, Bodine SC, Hughes DC.   +6 more
europepmc   +1 more source

Evolutionary Divergence of an Ethylene‐Responsive Transcriptional Cascade Governs a Dose‐Dependent Balance between Cotton Fiber Length and Strength

Advanced Science, EarlyView.
A tunable, ethylene‐responsive cascade governing the dose‐dependent balance between fiber length and strength is unveiled. Elevated ethylene strengthens modern tetraploid cotton (G. hirsutum) fibers but elongates those of its diploid ancestor (G. arboreum). This phenotypic switch is traced to an evolutionary functional inversion of a conserved EIN3‐ERF‐
Jie Zhang, Mengli Yu, Yuling Guo, Jie Li, Gailing Gu, Ghulam Hussain, Shuya Ma, Fuguang Li, Hongwei Xue, Zhaoen Yang, Zuoren Yang   +10 more
wiley   +1 more source

Molecular mechanisms and potential targeting strategies of ubiquitin‑proteasome system‑mediated PD‑1/PD‑L1 ubiquitination in tumor immune suppression (Review). [PDF]

Oncol Rep
Gu LH, Guo A, Ding YY, Wang XJ, Zhang HX, Duan WL, Zhang BG.   +6 more
europepmc   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

UBR5: A New Player in Protein Quality Control for Skeletal Muscle Growth and Remodeling. [PDF]

Exerc Sport Sci Rev
Hughes DC, Bodine SC.
europepmc   +1 more source

USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage

Advanced Science, EarlyView.
This study reveals that the deubiquitinase USP11 stabilizes PGAM5, triggering neurotoxic astrocyte transformation after intracerebral hemorrhage. PGAM5 promotes mPTP opening and Drp1 dephosphorylation, synergistically amplifying mtDNA leakage into the cytosol and leading to cGAS–STING hyperactivation.
Jiaqing He, Zijuan Qin, Yaning Cai, Haixiao Liu, Tinghao Wang, Qing Hu, Yanni Xu, Pan Yang, Xun Wu, Yan Qu, Wei Guo   +10 more
wiley   +1 more source

Small-molecule degron mimetics for targeted protein degradation. [PDF]

Essays Biochem
Liu X.
europepmc   +1 more source

GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy

Advanced Science, EarlyView.
Uterine Gsk3b knockout impairs decidual cell terminal differentiation by causing lipid droplet accumulation. GSK3β phosphorylates RNF213 to promote its lysosomal degradation, thereby enhancing lipolysis. The released fatty acids undergo β‐oxidation to generate acetyl‐CoA, which modulates histone acetylation and regulates decidual cell terminal ...
Peiran Wang, Yedong Tang, Xueling Zhao, Yu Ni, Hualan Zhou, Enhao Zhang, Gaizhen Li, Han Cai, Yinan Wang, James R. Woodgett, Wenbo Deng, Haibin Wang, Zhongxian Lu, Haili Bao, Shuangbo Kong   +14 more
wiley   +1 more source