Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate [PDF]
Biochemistry, 2011 Ubiquitination of proteins provides a powerful and versatile post-translational signal in the eukaryotic cell. The formation of a thioester bond between ubiquitin (Ub) and the active site of a ubiquitin-conjugating enzyme (E2) is critical for the transfer of Ub to substrates. Assembly of a functional ubiquitin ligase (E3) complex poised for Ub transfer
Jonathan N, Pruneda +4 more
openaire +2 more sources
Generation and physiological roles of linear ubiquitin chains [PDF]
, 2012 Ubiquitination now ranks with phosphorylation as one of the best-studied post-translational modifications of proteins with broad regulatory roles across all of biology.
Iwai Kazuhiro +11 more
core +1 more source
SUV39 SET domains mediate crosstalk of heterochromatic histone marks
eLife, 2021 The SUV39 class of methyltransferase enzymes deposits histone H3 lysine 9 di- and trimethylation (H3K9me2/3), the hallmark of constitutive heterochromatin.
Alessandro Stirpe +7 more
doaj +1 more source
The Ubiquitination Machinery of the Ubiquitin System [PDF]
The Arabidopsis Book, 2014 The protein ubiquitin is a covalent modifier of proteins, including itself. The ubiquitin system encompasses the enzymes required for catalysing attachment of ubiquitin to substrates as well as proteins that bind to ubiquitinated proteins leading them to their final fate.
openaire +4 more sources
BRCA1 is a histone-H2A-specific ubiquitin ligase [PDF]
, 2014 The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and for silencing at DNA satellite repeat regions. Despite its links to chromatin,
Donna L. Mallery +15 more
core +1 more source
Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase η in Saccharomyces cerevisiae [PDF]
, 2007 Bypassing of DNA lesions by damage-tolerant DNA polymerases depends on the interaction of these enzymes with the monoubiquitylated form of the replicative clamp protein, PCNA.
Bielen, Aleksandra B. +3 more
core +1 more source
Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation [PDF]
, 2012 Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately ...
Amanda Denuc +14 more
core +2 more sources
Profiling Ubiquitin Chain Specificity and Topology Using Di-ubiquitin Probes [PDF]
, 2021 Ubiquitin chains of specific linkages are assembled by ubiquitin conjugating enzymes (E2s) and ubiquitin ligases (E3s) to encode unique signals in the cell.
Zhou, Han
core +1 more source
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes
Frontiers in Cell and Developmental Biology, 2021 Development is orchestrated through a complex interplay of multiple transcription factors. The comprehension of this interplay will help us to understand developmental processes.
Immacolata Giordano +15 more
doaj +1 more source
Ubiquitin ligases and beyond [PDF]
, 2012 First paragraph (this article has no abstract): In a review published in 2004 [1] and that still repays reading today, Cecile Pickart traced the evolution of research on ubiquitination from its origins in the proteasomal degradation of proteins through ...
Robertson Miranda +5 more
core +1 more source