Distinct ubiquitin binding modes exhibited by SH3 domains: Molecular determinants and functional implications [PDF]
, 2013 SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation.
Jerónimo Bravo (22727) +52 more
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Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4 [PDF]
, 2014 The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response.
Simpson, P +15 more
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Contributions of ubiquitin- and PCNA-binding domains to the activity of Polymerase η in Saccharomyces cerevisiae [PDF]
, 2007 Bypassing of DNA lesions by damage-tolerant DNA polymerases depends on the interaction of these enzymes with the monoubiquitylated form of the replicative clamp protein, PCNA.
Bielen, Aleksandra B. +3 more
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In the family with ubiquitin [PDF]
The EMBO Reports, 2011 The Cold Spring Harbor meeting on 'The Ubiquitin Family', held in May 2011, brought together scientists from a wide range of fields under the umbrella of ubiquitin and ubiquitin-like protein structure, function and regulation.
Alexandru, Gabriela +2 more
openaire +4 more sources
Ubiquitin ligases and beyond [PDF]
, 2012 First paragraph (this article has no abstract): In a review published in 2004 [1] and that still repays reading today, Cecile Pickart traced the evolution of research on ubiquitination from its origins in the proteasomal degradation of proteins through ...
Robertson Miranda +5 more
core +1 more source
Ubiquitin-dependent and independent pathways of mitophagy.
, 2023 (A) Canonical ubiquitin-dependent mitophagy. In basal conditions, the PINK1 serine/threonine protein kinase precursor is targeted to healthy mitochondria thanks to its MTS, allowing its interaction with the TOMM complex and its import from the OMM to the
Jérémy Verbeke (5396666) +2 more
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BRCA1 is a histone-H2A-specific ubiquitin ligase [PDF]
, 2014 The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and for silencing at DNA satellite repeat regions. Despite its links to chromatin,
Donna L. Mallery +14 more
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Rsp5 Ubiquitin Ligase Is Required for Protein Trafficking in Saccharomyces cerevisiae COPI Mutants [PDF]
, 2012 Retrograde trafficking from the Golgi to the endoplasmic reticulum (ER) depends on the formation of vesicles coated with the multiprotein complex COPI.
Joanna Kaminska +11 more
core +3 more sources
The fanconi anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL [PDF]
, 2015 The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can lead to leukemia and bone marrow failure.
Howard, Mark J. +8 more
core +1 more source
Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]
, 2000 This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia +6 more
core +1 more source