Results 31 to 40 of about 596,162 (342)
SALL1 Modulates CBX4 Stability, Nuclear Bodies, and Regulation of Target Genes
Frontiers in Cell and Developmental Biology, 2021 Development is orchestrated through a complex interplay of multiple transcription factors. The comprehension of this interplay will help us to understand developmental processes.
Immacolata Giordano +15 more
doaj +1 more source
Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins [PDF]
, 2008 Background: The delivery of ubiquitinated proteins to the proteasome for degradation is a key step in the regulation of the ubiquitin-proteasome pathway, yet the mechanisms underlying this step are not understood in detail.
Deshaies, Raymond J. +6 more
core +6 more sources
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Nature, 2015 Protein aggregates and damaged organelles are tagged with ubiquitin chains to trigger selective autophagy. To initiate mitophagy, the ubiquitin kinase PINK1 phosphorylates ubiquitin to activate the ubiquitin ligase parkin, which builds ubiquitin chains ...
M. Lazarou +8 more
semanticscholar +1 more source
Sugar-Recognizing Ubiquitin Ligases: Action Mechanisms and Physiology
Frontiers in Physiology, 2019 F-box proteins, the substrate recognition subunits of SKP1–CUL1–F-box protein (SCF) E3 ubiquitin ligase complexes, play crucial roles in various cellular events mediated by ubiquitination.
Yukiko Yoshida +2 more
doaj +1 more source
Development of an Individualized Ubiquitin Prognostic Signature for Clear Cell Renal Cell Carcinoma
Frontiers in Cell and Developmental Biology, 2021 Clear cell renal cell carcinoma (ccRCC) is a common tumor type in genitourinary system and has a poor prognosis. Ubiquitin dependent modification systems have been reported in a variety of malignancies and have influenced tumor genesis and progression ...
Yue Wu +23 more
doaj +1 more source
Slx5/Slx8-dependent ubiquitin hotspots on chromatin contribute to stress tolerance [PDF]
, 2019 Chromatin is a highly regulated environment, and protein association with chromatin is often controlled by post-translational modifications and the corresponding enzymatic machinery.
Habermann, B. +6 more
core +3 more sources
Emerging functions of branched ubiquitin chains
Cell Discovery, 2021 Ubiquitylation is a critical post-translational modification that controls a wide variety of processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different cellular functions and control the stability, activity ...
Michael E. French +2 more
semanticscholar +1 more source
Asian Journal of Andrology, 2015 In this experimental prospective study, we aimed to analyze the effect of transient scrotal hyperthermia on the male reproductive organs, from the perspective of sperm parameters, semen plasma biochemical markers, and oxidative stress, to evaluate ...
Meng Rao +6 more
doaj +1 more source
A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation. [PDF]
, 2015 Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes.
Caddick, S +4 more
core +1 more source
Ubiquitination accomplished: E1 and E2 enzymes were not necessary [PDF]
, 2016 Qiu et al. (2016) show that a mono-ADP-ribosyltransferase, SdeA, from Legionella pneumophila catalyzes ADP-ribosylation of ubiquitin, allowing SdeA to modify substrate with ubiquitin in the absence of E1 and E2 ...
Huang, Danny T., Nakasone, Mark
core +1 more source