Results 51 to 60 of about 383,830 (310)

Ubiquitin-proteasome dependent mitochondrial protein quality control [PDF]

, 2014
Dysfunctional mitochondria cause many neurodegenerative disorders and with aging in general, mechanisms of mitochondrial quality control are essential for cellular function.
Benischke, Anne-Sophie
core   +1 more source

The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress

eLife, 2013
Secretory cargo that cannot fold properly in the ER are selectively targeted for removal by a well-studied ER-associated degradation pathway, or ERAD.
Yingying Zhao, Jason A MacGurn, Max Liu, Scott Emr   +3 more
doaj   +1 more source

Ubiquitin System [PDF]

International Journal of Molecular Sciences, 2018
Ever since the discovery of ubiquitin in 1975[...]
openaire   +2 more sources

A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection

eLife, 2014
Virus-host interactions drive a remarkable diversity of immune responses and countermeasures. We found that two RNA viruses with broad host ranges, vesicular stomatitis virus (VSV) and Sindbis virus (SINV), are completely restricted in their replication ...
Don B Gammon, Sophie Duraffour, Daniel K Rozelle, Heidi Hehnly, Rita Sharma, Michael E Sparks, Cara C West, Ying Chen, James J Moresco, Graciela Andrei, John H Connor, Darryl Conte Jr., Dawn E Gundersen-Rindal, William L Marshall, John R Yates, Neal Silverman, Craig C Mello   +16 more
doaj   +1 more source

The Drosophila F-box protein Fbxl7 binds to the protocadherin Fat and regulates Dachs localization and Hippo signaling

eLife, 2014
The Drosophila protocadherin Fat (Ft) regulates growth, planar cell polarity (PCP) and proximodistal patterning. A key downstream component of Ft signaling is the atypical myosin Dachs (D).
Justin A Bosch, Taryn M Sumabat, Yassi Hafezi, Brett J Pellock, Kevin D Gandhi, Iswar K Hariharan   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

DNA polymerase α/primase extraction from chromatin by VCP/p97 restricts ATR activation during unperturbed DNA replication

Nature Communications
The replication stress response is an essential pathway that deals with the obstacles that halt the progression of DNA replication forks even during an unperturbed S phase.
Sara Rodríguez-Acebes, Rodrigo Martín-Rufo, Alicia Gómez-Moya, Scott B. Churcher, Alejandro Fernández-Llorente, Guillermo de la Vega-Barranco, Alejandra Perona, Pilar Oroz, Elena Martín-Doncel, Luis Ignacio Toledo, Juan Méndez, Emilio Lecona   +11 more
doaj   +1 more source

Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis

eLife, 2014
Linear Ubiquitin chain Assembly Complex (LUBAC) is an E3 ligase complex that generates linear ubiquitin chains and is important for tumour necrosis factor (TNF) signaling activation.
Snehlata Kumari, Younes Redouane, Jaime Lopez-Mosqueda, Ryoko Shiraishi, Malgorzata Romanowska, Stefan Lutzmayer, Jan Kuiper, Conception Martinez, Ivan Dikic, Manolis Pasparakis, Fumiyo Ikeda   +10 more
doaj   +1 more source

A Ubiquitin-like Protein Unleashes Ubiquitin Ligases [PDF]

Cell, 2008
Modification of cullin-RING ubiquitin ligases by the ubiquitin-like molecule Nedd8 promotes substrate ubiquitination. A crystal structure of a cullin modified by Nedd8 recently reported in Cell (Duda et al., 2008) and a biochemical study in Molecular Cell (Saha and Deshaies, 2008) reveal the dramatic impact on the ligase machinery by conjugation of ...
Saifee, Nabiha Huq, Zheng, Ning
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source