Results 51 to 60 of about 376,415 (308)
Ubiquitin-dependent and independent pathways of mitophagy.
, 2023 (A) Canonical ubiquitin-dependent mitophagy. In basal conditions, the PINK1 serine/threonine protein kinase precursor is targeted to healthy mitochondria thanks to its MTS, allowing its interaction with the TOMM complex and its import from the OMM to the
Jérémy Verbeke (5396666) +2 more
core +1 more source
Cells, 2019 Ubiquitin is a highly conserved small eukaryotic protein. It is generated by proteolytic cleavage of precursor proteins in which it is fused either to itself, constituting a polyubiquitin precursor of head-to-tail monomers, or as a single N-terminal ...
Sara Martín-Villanueva +3 more
doaj +1 more source
Pharmaceuticals, 2021 Background: The mTOR signaling pathway is inactivated by AMPK’s tumor-suppressing function. It is recognized that ubiquitin conjugating enzyme 2O (UBE2O), which directly targets AMPK for ubiquitination and degradation, is intensified in human cancers ...
Jae-Heon Kim +12 more
doaj +1 more source
Multiple C-terminal Lysine residues target p53 for ubiquitin-proteasome-mediated degradation [PDF]
, 2000 This work was supported by the Medical Research Council, the Biotechnology and Biological Research Council, and the Cancer Research Campaign. D.P.L. is a Gibb fellow of the Cancer Research Campaign.In normal cells, p53 is maintained at a low level by ...
Lain, Sonia +6 more
core +1 more source
Cells, 2014 The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small
Jamie J. L. Williams +2 more
doaj +1 more source
Ubiquitination drives COPI priming and Golgi SNARE localization
eLife, 2022 Deciphering mechanisms controlling SNARE localization within the Golgi complex is crucial to understanding protein trafficking patterns within the secretory pathway.
Swapneeta S Date +10 more
doaj +1 more source
The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. [PDF]
, 2014 p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53 pathway, little is known about the mechanisms of proteasomal recognition of ubiquitinated p53 and
J Das +11 more
core +1 more source
eLife, 2014 The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, such as control of growth and ...
Weiping Wang, Tao Wu, Marc W Kirschner
doaj +1 more source
Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations
eLife, 2022 The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors (TFs) (e.g., c-Myc, c-Jun, and Notch).
H Nayanga Thirimanne +10 more
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The fanconi anemia DNA repair pathway is regulated by an interaction between ubiquitin and the E2-like fold domain of FANCL [PDF]
, 2015 The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can lead to leukemia and bone marrow failure.
Howard, Mark J. +8 more
core +1 more source