Results 51 to 60 of about 596,162 (342)
Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation [PDF]
, 2018 The E3 ligase parkin ubiquitinates outer mitochondrial membrane proteins during oxidative stress and is linked to early-onset Parkinson’s disease. Parkin is autoinhibited but is activated by the kinase PINK1 that phosphorylates ubiquitin leading to ...
Aguirre, Jacob D. +9 more
core +1 more source
Ubiquitin signaling in cell cycle control and tumorigenesis
Cell Death and Differentiation, 2020 Cell cycle progression is a tightly regulated process by which DNA replicates and cell reproduces. The major driving force underlying cell cycle progression is the sequential activation of cyclin-dependent kinases (CDKs), which is achieved in part by the
Fabin Dang, Li Nie, Wenyi Wei
semanticscholar +1 more source
Cells, 2019 The ubiquitin proteasome system (UPS) plays an important role in regulating numerous cellular processes, and a dysfunctional UPS is thought to contribute to motor neuron disease.
Monique Bax +12 more
doaj +1 more source
Resolving the Complexity of Ubiquitin Networks
Frontiers in Molecular Biosciences, 2020 Ubiquitination regulates nearly all cellular processes by coordinated activity of ubiquitin writers (E1, E2, and E3 enzymes), erasers (deubiquitinating enzymes) and readers (proteins that recognize ubiquitinated proteins by their ubiquitin-binding ...
Katarzyna Kliza, Koraljka Husnjak
doaj +1 more source
Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities [PDF]
, 2014 E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success.
Adams J. +31 more
core +5 more sources
Cells, 2019 Ubiquitin is a highly conserved small eukaryotic protein. It is generated by proteolytic cleavage of precursor proteins in which it is fused either to itself, constituting a polyubiquitin precursor of head-to-tail monomers, or as a single N-terminal ...
Sara Martín-Villanueva +3 more
doaj +1 more source
Pharmaceuticals, 2021 Background: The mTOR signaling pathway is inactivated by AMPK’s tumor-suppressing function. It is recognized that ubiquitin conjugating enzyme 2O (UBE2O), which directly targets AMPK for ubiquitination and degradation, is intensified in human cancers ...
Jae-Heon Kim +12 more
doaj +1 more source
MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells [PDF]
, 2018 Dendritic cells (DCs) produce major histocompatibility complex II (MHCII) in large amounts to function as professional antigen presenting cells. Paradoxically, DCs also ubiquitinate and degrade MHCII in a constitutive manner.
Anderson +54 more
core +2 more sources
Cells, 2014 The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small
Jamie J. L. Williams +2 more
doaj +1 more source
Ubiquitination drives COPI priming and Golgi SNARE localization
eLife, 2022 Deciphering mechanisms controlling SNARE localization within the Golgi complex is crucial to understanding protein trafficking patterns within the secretory pathway.
Swapneeta S Date +10 more
doaj +1 more source