Results 41 to 50 of about 353,107 (313)
Cells, 2014 The realisation that unregulated activation of the Janus kinase–signal transducer and activator of transcription (JAK–STAT) pathway is a key driver of a wide range of diseases has identified its components as targets for therapeutic intervention by small
Jamie J. L. Williams +2 more
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Ubiquitination drives COPI priming and Golgi SNARE localization
eLife, 2022 Deciphering mechanisms controlling SNARE localization within the Golgi complex is crucial to understanding protein trafficking patterns within the secretory pathway.
Swapneeta S Date +10 more
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The degradation of p53 and its major E3 ligase Mdm2 is differentially dependent on the proteasomal ubiquitin receptor S5a. [PDF]
, 2014 p53 and its major E3 ligase Mdm2 are both ubiquitinated and targeted to the proteasome for degradation. Despite the importance of this in regulating the p53 pathway, little is known about the mechanisms of proteasomal recognition of ubiquitinated p53 and
J Das +11 more
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eLife, 2014 The primary cilium has an important role in signaling; defects in structure are associated with a variety of human diseases. Much of the most basic biology of this organelle is poorly understood, even basic mechanisms, such as control of growth and ...
Weiping Wang, Tao Wu, Marc W Kirschner
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Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations
eLife, 2022 The Fbw7 ubiquitin ligase targets many proteins for proteasomal degradation, which include oncogenic transcription factors (TFs) (e.g., c-Myc, c-Jun, and Notch).
H Nayanga Thirimanne +10 more
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International Journal of Molecular Sciences, 2018 Ever since the discovery of ubiquitin in 1975[...]
openaire +2 more sources
eLife, 2013 Secretory cargo that cannot fold properly in the ER are selectively targeted for removal by a well-studied ER-associated degradation pathway, or ERAD.
Yingying Zhao +3 more
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A single vertebrate DNA virus protein disarms invertebrate immunity to RNA virus infection
eLife, 2014 Virus-host interactions drive a remarkable diversity of immune responses and countermeasures. We found that two RNA viruses with broad host ranges, vesicular stomatitis virus (VSV) and Sindbis virus (SINV), are completely restricted in their replication ...
Don B Gammon +16 more
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, 2012 First paragraph (this article has no abstract): In a review published in 2004 [1] and that still repays reading today, Cecile Pickart traced the evolution of research on ubiquitination from its origins in the proteasomal degradation of proteins through ...
Robertson Miranda +5 more
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eLife, 2014 The Drosophila protocadherin Fat (Ft) regulates growth, planar cell polarity (PCP) and proximodistal patterning. A key downstream component of Ft signaling is the atypical myosin Dachs (D).
Justin A Bosch +5 more
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