Results 11 to 20 of about 596,162 (342)
An expanded lexicon for the ubiquitin code
Nature Reviews Molecular Cell Biology, 2022 Recent studies have expanded our understanding of the mechanisms and functions of ubiquitylation. Pathogens rewrite ubiquitylation to promote infection through unconventional ubiquitylation involving lipids and sugars, and structural studies have ...
Ivan Đikić, Brenda A Schulman
exaly +2 more sources
International Journal of Molecular Sciences, 2018 Ever since the discovery of ubiquitin in 1975[...].
N. Nakamura
semanticscholar +3 more sources
Cell Research, 2016 Protein ubiquitination is a dynamic multifaceted post-translational modification involved in nearly all aspects of eukaryotic biology. Once attached to a substrate, the 76-amino acid protein ubiquitin is subjected to further modifications, creating a ...
Kirby N. Swatek, D. Komander
semanticscholar +3 more sources
Function and regulation of cullin–RING ubiquitin ligases
Nature Reviews Molecular Cell Biology, 2005 Raymond J Deshaies
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Distinct ubiquitin binding modes exhibited by SH3 domains: Molecular determinants and functional implications [PDF]
, 2013 SH3 domains constitute a new type of ubiquitin-binding domains. We previously showed that the third SH3 domain (SH3-C) of CD2AP binds ubiquitin in an alternative orientation.
Azuaga, Ana I. +8 more
core +16 more sources
Structural insights into the catalysis and regulation of E3 ubiquitin ligases
Nature Reviews Molecular Cell Biology, 2016 Lori Buetow, Danny T Huang
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The unifying catalytic mechanism of the RING-between-RING E3 ubiquitin ligase family
Nature Communications, 2023 RBR E3 ubiquitin ligases utilise a 2-step catalytic mechanism previously defined for only few of the RBR family members. Here, the authors examine the poorly studied RBRs HOIL-1 and RNF216 to define general principles of RBR catalysis and regulation and ...
Xiangyi S. Wang +6 more
doaj +1 more source
Cracking the Ubiquitin Code: The Ubiquitin Toolbox [PDF]
Current Issues in Molecular Biology, 2019 Ubiquitination, a post-translational modification, regulates a vast array of fundamental biological processes with dysregulation of the dedicated enzymes giving rise to pathologies such as cancer and neurodegenerative diseases. Assembly and its ensuing removal of this post-translational modification, determining a large variety of biological functions,
Mulder, M.P.C., Witting, K.F., Ovaa, H.
openaire +3 more sources
Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]
, 2012 Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone +2 more
core +2 more sources
The Ubiquitin Ligase SIAH2 Negatively Regulates Glucocorticoid Receptor Activity and Abundance
Biomedicines, 2020 Glucocorticoids are clinically essential drugs used routinely to control inflammation. However, a host of metabolic side effects manifests upon usage beyond a few days.
Susan J. Burke +7 more
doaj +1 more source