Results 301 to 310 of about 574,104 (383)

Heterogeneity in the structure of the ubiquitin conjugates of human alpha globin.

, 1994
Joseph R. Shaeffer
openalex   +1 more source

Conformational dynamics of the bacterial E3 ligase SspH1

Kennedy CR, Esposito D, House D, Rittinger K.   +3 more
europepmc   +1 more source

Correction to "TRIM25 mutation (p.C168*), coding for an E3 ubiquitin ligase, is a cause of early-onset autosomal dominant dementia with amyloid load and Parkinsonism." [PDF]

Alzheimers Dement
europepmc   +1 more source

Activity-based protein profiling reveals both canonical and novel ubiquitin pathway enzymes in Plasmodium. [PDF]

PLoS Pathog
Smith C, Hajisadeghian M, van Noort GJVH, Deery MJ, Pinto-Fernández A, Kessler BM, Artavanis-Tsakonas K.   +6 more
europepmc   +1 more source

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou   +7 more
wiley   +1 more source

The role of ubiquitination and deubiquitination in the pathogenesis of non-alcoholic fatty liver disease. [PDF]

Front Immunol
Zhang L, Liu S, Zhao Q, Liu X, Zhang Q, Liu M, Zhao W.   +6 more
europepmc   +1 more source

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

Identification and validation of USP15 and CUL2 as ubiquitination related biomarker in chronic obstructive pulmonary disease. [PDF]

Hereditas
Sun S, Zhang Z, Zhao H.
europepmc   +1 more source

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

CXXC5 is a ubiquitinated protein and is degraded by the ubiquitin-proteasome pathway. [PDF]

Protein Sci
Ayten H, Toker P, Turan Duman G, Olgun ÇE, Demiralay ÖD, Bınarcı B, Güpür G, Yaşar P, Akman HB, Haberkant P, Muyan M.   +10 more
europepmc   +1 more source