Results 121 to 130 of about 278,733 (404)

Quantitative Analysis of Ubiquitinated Proteins in Human Pituitary and Pituitary Adenoma Tissues

Frontiers in Endocrinology, 2019
Protein ubiquitination is an important post-translational modification that is associated with multiple diseases, including pituitary adenomas (PAs). Protein ubiquitination profiling in human pituitary and PAs remains unknown.
Shehua Qian, Shehua Qian, Shehua Qian, Xiaohan Zhan, Xiaohan Zhan, Xiaohan Zhan, Miaolong Lu, Miaolong Lu, Miaolong Lu, Na Li, Na Li, Na Li, Ying Long, Ying Long, Ying Long, Xuejun Li, Dominic M. Desiderio, Xianquan Zhan, Xianquan Zhan, Xianquan Zhan, Xianquan Zhan   +20 more
doaj   +1 more source

Mechanisms underlying linear ubiquitination and implications in tumorigenesis and drug discovery

Cell Communication and Signaling, 2023
Linear ubiquitination is a distinct type of ubiquitination that involves attaching a head-to-tail polyubiquitin chain to a substrate protein. Early studies found that linear ubiquitin chains are essential for the TNFα- and IL-1-mediated NF-κB signaling ...
Jack Li, Sijin Liu, Shitao Li
doaj   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Translesion synthesis in mammalian cells [PDF]

, 2006
DNA damage blocks the progression of the replication fork. In order to circumvent the damaged bases, cells employ specialized low stringency DNA polymerases, which are able to carry out translesion synthesis (TLS) past different types of damage. The five
Alan R. Lehmann, Avkin, Avkin, Bienko, Garg, Gibbs, Gibbs, Gibbs, Guo, Haracska, Hoege, Huang, Johnson, Kannouche, Kannouche, King, Lehmann, Lemontt, Ling, Maher, Masutani, Masutani, McCulloch, Murakumo, Nair, Nakajima, Nelson, Nelson, Nelson, Ogi, Ohmori, Pages, Stelter, Tissier, Vidal, Watanabe   +35 more
core   +2 more sources

Uncovering Ubiquitin and Ubiquitin-like Signaling Networks

Chemical Reviews, 2011
Proteomes are significantly more complex than genomes and transcriptomes due to protein processing and extensive post-translational modification (PTM) of proteins. Hundreds of different modifications exist. Release 66 of the RESID database(1) (http://www.ebi.ac.uk/RESID/) contains 559 different modifications, including small chemical modifications such
openaire   +4 more sources

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

Dipole-dipole interactions in protein-protein complexes: a quantum mechanical study of the ubiquitin-Dsk2 complex [PDF]

arXiv, 2013
Quantum mechanical calculations are performed on the proteins that constitute the ubiquitin-Dsk2 complex whose atomic structure has been experimentally determined by NMR spectroscopy (PDB id 1WR1). The results indicate that the dipole moment vectors of the two proteins are aligned in a head-to-tail orientation while forming and angle of ~130{\deg ...
arxiv  

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination

Science, 2018
Regulation of RAS by ubiquitination The protein LZTR1 is mutated in human cancers and developmental diseases. Work from two groups now converges to implicate the protein in regulating signaling by the small guanosine triphosphatase RAS.
M. Steklov, Silvia Pandolfi, M. Baietti, A. Batiuk, P. Carai, P. Najm, Mingzhen Zhang, Hyunbum Jang, Fabrizio Renzi, Yanyan Cai, L. A. Asbagh, Tibor J. Pastor, M. D. Troyer, Michal Simicek, Enrico Radaelli, H. Brems, Eric Legius, Jan Tavernier, Kris Gevaert, Francis Impens, L. Messiaen, L. Messiaen, Ruth Nussinov, Ruth Nussinov, Stephane Heymans, Stephane Heymans, S. Eyckerman, A. Sablina   +27 more
semanticscholar   +1 more source

RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA

Nature Communications, 2020
MAVS and MITA are essential adaptor proteins mediating innate antiviral immune responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays dual roles in response to RNA or DNA virus infections by catalyzing distinct types of ...
Zhi-Dong Zhang, Tianchen Xiong, Shu-Qi Yao, M. Wei, Ming Chen, Dandan Lin, Bo Zhong   +6 more
semanticscholar   +1 more source

A role for chromatin remodellers in replication of damaged DNA [PDF]

, 2011
In eukaryotic cells, replication past damaged sites in DNA is regulated by the ubiquitination of proliferating cell nuclear antigen (PCNA). Little is known about how this process is affected by chromatin structure.
Chambers, Anna L, Downs, Jessica A, Lehmann, Alan R, Niimi, Atsuko   +3 more
core   +2 more sources