Results 151 to 160 of about 187,561 (340)

MTCH2 Deficiency Promotes E2F4/TFRC‐Mediated Ferroptosis and Sensitizes Colorectal Cancer Liver Metastasis to Sorafenib

Advanced Science, EarlyView.
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing, Jiangbo Chen, Hao Hao, Xiaowen Qiao, Xinying Yang, Kai Weng, Jie Chen, Lin Song, Tianqi Liu, Yifan Hou, Tongkun Song, Yumeng Ran, Bo Chen, Hong Yang, Wei Zhao, Zaozao Wang, Jiabo Di, Beihai Jiang, Xiangqian Su   +18 more
wiley   +1 more source

Ligand binding directly stimulates ubiquitination of the inositol 1,4,5-trisphosphate receptor [PDF]

, 2000
Chang-Cheng Zhu, Richard J.H. Wojcikiewicz   +1 more
openalex   +2 more sources

Casein Kinase I-dependent Phosphorylation within a PEST Sequence and Ubiquitination at Nearby Lysines Signal Endocytosis of Yeast Uracil Permease [PDF]

, 2000
Christelle Marchal, Rosine Haguenauer‐Tsapis, Danièle Urban‐Grimal   +2 more
openalex   +1 more source

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Homodimer of Two F-box Proteins βTrCP1 or βTrCP2 Binds to IκBα for Signal-dependent Ubiquitination [PDF]

, 2000
Hiroshi Suzuki, Tomoki Chiba, Toshiaki Suzuki, Takashi Fujita, Tsuneo Ikenoue, Masao Omata, Kiyoshi Furuichi, Hisataka Shikama, Keiji Tanaka   +8 more
openalex   +1 more source

Intestinal Epithelial‐Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78‐mediated Endoplasmic Reticulum Stress

Advanced Science, EarlyView.
USP13 deficiency in intestinal epithelial cells aggravates DSS‐induced colitis by enhancing ER stress and apoptosis. USP13 interacts with GRP78 and reduces its K63‐linked ubiquitination to alleviate epithelial injury. Restoring USP13 expression or targeting the USP13‐GRP78 axis may represent a promising strategy for treating inflammatory bowel disease ...
Chenchen Qian, Chenghong Hu, Yong Xu, Wentao Xu, Zhe Wang, Wan Gan, Weiyang Tang, Lijiang Huang, Aleksandr V. Samorodov, Yi Wang   +9 more
wiley   +1 more source

Ubiquitin, ubiquitination and the ubiquitin-proteasome system in cancer [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
openaire   +2 more sources

Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1

Nature Communications
Ubiquitination, catalyzed usually by a three-enzyme cascade (E1, E2, E3), regulates various eukaryotic cellular processes. E3 ligases are the most critical components of this catalytic cascade, determining both substrate specificity and ...
Xiangwei Wu, Yunxiang Du, Lu-Jun Liang, Ruichao Ding, Tianyi Zhang, Hongyi Cai, Xiaolin Tian, Man Pan, Lei Liu   +8 more
doaj   +1 more source

Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling.

, 1993
Seijiro Mori, Carl‐Henrik Heldin, Lena Claesson‐Welsh   +2 more
openalex   +1 more source