Results 151 to 160 of about 278,733 (404)

Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair. [PDF]

, 2014
Arsenic is a widespread environmental contaminant. However, the exact molecular mechanisms underlying the carcinogenic effects of arsenic remain incompletely understood.
Cai, Qian, Dai, Xiaoxia, Lin, Krystal, Paramasivam, Manikandan, Seidman, Michael M, Song, Jikui, Wang, Pengcheng, Wang, Yinsheng, Zhang, Fan   +8 more
core   +1 more source

Infammatory bowel disease-associated ubiquitin ligase RNF183 promotes lysosomal degradation of DR5 and TRAIL-induced caspase activation [PDF]

, 2019
Open access.金沢大学医薬保健研究域医学系journal ...
30580394, Atsushi Saito, Fumika Sakaue, Kazunori Imaizumi, Koji Matsuhisa, Masayuki Kaneko, Rie Asada, Takumi Okamoto, Yan Wu, Yuka Kimura, 齋藤 敦   +10 more
core   +2 more sources

The Regulation of Trace Metal Elements in Cancer Ferroptosis

Advanced Biology, EarlyView.
The induction of ferroptosis inhibits tumor growth, enhances anticancer efficacy, and overcomes drug resistance. Recent evidence shows nonferrous metal elements play a role in ferroptosis. This review focuses on how trace metals regulate ferroptosis processes like iron accumulation, lipid peroxidation, and antioxidant defense.
Xiaoyan Wang, Yuanyuan Xue, Lei Chang, Xuena Zhu, Wenjun Liu, Tingbo Liang   +5 more
wiley   +1 more source

Ubiquitinome Profiling Reveals the Landscape of Ubiquitination Regulation in Rice Young Panicles

Genomics, Proteomics & Bioinformatics, 2020
Ubiquitination, an essential post-transcriptional modification (PTM), plays a vital role in nearly every biological process, including development and growth.
Liya Zhu, Han Cheng, Guoqing Peng, Shuansuo Wang, Zhiguo Zhang, Erdong Ni, Xiangdong Fu, Chuxiong Zhuang, Zexian Liu, Hai Zhou   +9 more
doaj  

Histone ubiquitination and deubiquitination in transcription, DNA damage response, and cancer

Frontiers in Oncology, 2012
Histone post-transcriptional modifications play essential roles in regulation of all DNA related processes. Among them, histone ubiquitination has been discovered for more than three decades.
Jian eCao, Qin eYan
doaj   +1 more source

Crowding effects on the mechanical stability and unfolding pathways of Ubiquitin [PDF]

, 2008
The interior of cells is crowded thus making it important to assess the effects of macromolecules on the folding of proteins. Using the Self-Organized Polymer (SOP) model, which is a coarse-grained representation of polypeptide chains, we probe the mechanical stability of Ubiquitin (Ub) monomers and trimers ((Ub)$_3$) in the presence of monodisperse ...
arxiv   +1 more source

SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy

Autophagy, 2019
The ubiquitination of mitochondrial proteins labels damaged mitochondria for degradation through mitophagy. We recently developed an in vivo system in which mitophagy is slowed by inhibiting mitochondrial division through knockout of Dnm1l/Drp1, a ...
Tatsuya Yamada, T. Dawson, T. Yanagawa, M. Iijima, H. Sesaki   +4 more
semanticscholar   +1 more source

Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell development [PDF]

, 2016
Non-proteolytic ubiquitin signaling mediated by Lys63 ubiquitin chains plays a critical role in multiple pathways that are key to the development and activation of immune cells.
Aggarwal, Akira, Allman, Amanda Lopacinski, Anna C. Belkina, Baer, Banerji, Barbara S. Nikolajczyk, Bhoj, Bianchi, Bogdan Tanasa, Branigan, Cardamone, Cardamone, Cariappa, Carly T. Cederquist, Cederquist, Chen, Chen, Cheng, Chow, Chu, Chun, Cilloni, Ciriello, Claudia Lentucci, Compagno, Coornaert, Davis, DeFuria, Dengler, Diederichs, Dunne, Fabris, Fan, Flemming, Giltiay, Guo, Habelhah, Haslinger, Hayden, Ho, Holly E. Johnson, Honma, Horikawa, Ikeda, Iwai, Jakobsson, Jennifer Snyder-Cappione, Jiang, Jiang, Jin, Jin, Juang, Jumaa, Karin, Kato, Katz, Kobayashi, Kotecha, Landmann, Langmead, Lee, Lee, Li, Lino, Liu, M. Dafne Cardamone, Malynn, Marchant, Maspero, Michelle Chan, Minegishi, Moran, Nagy, Notley, Ochiai, Oeckinghaus, Ori, Panda, Pappu, Peng, Peng, Pickart, Pillai, Popovic, Pruneda, Pugh, Pulvino, Qiu, Rickert, Ruland, Saito, Sanyal, Sato, Schmidt-Supprian, Shah, Sherry Prasad, Skaug, Spain, Stefano Monti, Stephens, Stringer, Sun, Sun, Szydlowski, Tavares, Toubal, Touma, Valentina Perissi, Venteclef, Wang, Wasserman, Weigert, Wiener, Witt, Wu, Yamamoto, Yang, Yao, Zhang, Zhang, Zhang   +122 more
core   +1 more source

A Universal Biomimetic Approach for Making Artificial Antigen‐Presenting Cells for T Cell Activation

Advanced Functional Materials, EarlyView.
This study shows a biomimetic silica microcapsule (SMC) fabrication method under mild conditions for making artificial antigen‐presenting cells (aAPCs). Inspired by marine biomineralization, peptide‐mediated biosilicification enables silica shell formation on emulsion templates. The resulting SMCs possess a core–shell structure, controlled fluorescence
Fei Hou, Supun Ranaweera, Xiangke Li, Ruirui Qiao, Yue Hui, Chun‐Xia Zhao   +5 more
wiley   +1 more source

SCUD: Saccharomyces Cerevisiae Ubiquitination Database

BMC Genomics, 2008
Background Ubiquitination is an important post-translational modification involved in diverse biological processes. Therefore, genomewide representation of the ubiquitination system for a species is important. Description SCUD is a web-based database for
Jung Jin Woo, Lee Minho, Lee Won-Chul, Kim Kwang Pyo, Kim Dongsup   +4 more
doaj   +1 more source