Results 191 to 200 of about 274,920 (356)

JP2 and JCN Crosstalk Abrogate MURF1-Mediated JCN Ubiquitination and Degradation in Cardiomyocytes. [PDF]

JACC Basic Transl Sci
Ji X, Huang Y, Wang J, Dong Z, Ni R, Su Z, Zheng D, Fan GC, Jones DL, Song LS, Chakrabarti S, Song J, Su Z, Peng T.   +13 more
europepmc   +1 more source

Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy [PDF]

, 2017
Mengjie Hu, Qiang Luo, Gulimiran Alitongbieke, Shuyi Chong, Chenting Xu, Lei Xie, Xiaohui Chen, Duo Zhang, Yuqi Zhou, Zhaokai Wang, Xiaohong Ye, Lijun Cai, Fang Zhang, Huibin Chen, Fuquan Jiang, Hui Fang, Shanjun Yang, Jie Liu, María T. Diaz‐Meco, Ying Su, Hu Zhou, Jorge Moscat, Xiangzhi Lin, Xiao-kun Zhang   +23 more
openalex   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

A tale of dual role: HECT‑type E3 ubiquitin ligase mechanisms in liver diseases (Review). [PDF]

Int J Mol Med
Li T, Chen H, Zhao P, Yin C, Song Z.
europepmc   +1 more source

Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis [PDF]

, 2006
Laurence Abrami, Stephen H. Leppla, F. Gisou van der Goot   +2 more
openalex   +1 more source

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source

The role of ubiquitination in the pathogenesis of atrial fibrillation: mechanisms and therapeutic implications. [PDF]

Front Pharmacol
Runtian Z, Xing G, You S, Zimeng S, Wenqiang H, Likun C, Qingrun M, Jingquan Z.   +7 more
europepmc   +1 more source

RNF111-Dependent Neddylation Activates DNA Damage-Induced Ubiquitination [PDF]

, 2013
Teng Ma, Yibin Chen, Feng Zhang, Chao-Yie Yang, Shaomeng Wang, Xiaochun Yu   +5 more
openalex   +1 more source

PRMT5/Sohlh2/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The cover image shows that vascular endothelial cells play an important role in lung metastasis of TNBC. Endothelial Sohlh2 acts as a gatekeeper against TNBC lung metastasis by limiting endothelial activation and tumor cell passage. PRMT5 reduces Sohlh2 stability, weakening this protective barrier.
Ruihong Zhang, Fengqin Wang, Lanlan Liu, Qi Zhang, Xiaoning Huo, Yanhui Nan, Yanli Dong, Yunling Xiao, Jing Hao   +8 more
wiley   +1 more source

Updates on the role of TRIM proteins in AIDS: molecular mechanisms and potential for interventions. [PDF]

Front Immunol
Chen J, Chen S, Xu Y, Wang X, Jiang M.
europepmc   +1 more source