Results 211 to 220 of about 169,475 (267)

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Updates on the role of TRIM proteins in AIDS: molecular mechanisms and potential for interventions. [PDF]

Front Immunol
Chen J, Chen S, Xu Y, Wang X, Jiang M.
europepmc   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Regulation of HPV-16 infection by ubiquitination of the L1 major capsid protein. [PDF]

J Virol
Trejo-Cerro O, Bergant Marušič M, Wlodarczyk P, Repnik U, Lovšin N, Myers MP, Garcea RL, Banks L, Broniarczyk J.   +8 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

E3 ubiquitin ligases in neurodegenerative diseases. [PDF]

Mil Med Res
Hou DL, Ho J, Guan T, Dong XX, Zeng L, Sanders LH, Wu YC, Tan EK, Zhou ZD.   +8 more
europepmc   +1 more source

mGem: Cut4/Apc1 and its prion form at the cross roads of cell cycle regulation, heterochromatin organization, RNAi, stress response, and evolution. [PDF]

mBio
Sharma S, Singh J.
europepmc   +1 more source

Multiple Regulatory Mechanisms of Post-Translational Modifications and Therapeutic Potential of Mitotic Catastrophe. [PDF]

Int J Mol Sci
Zhang QY, Chen X, Li SK, Cao LZ, Wang SY, He YJ, Zhang XL, Liu JW, Liu XF.   +8 more
europepmc   +1 more source

Deubiquitinase YOD1 Inhibition Suppresses DEX- and Denervation-Induced Muscle Atrophy Through MAFbx Destabilization. [PDF]

J Cachexia Sarcopenia Muscle
Chae J, Woo SM, Seo SU, Yook S, Cho HJ, Lee JY, Min KJ, Park J, Ryu D, Kwon TK.   +9 more
europepmc   +1 more source

Crosstalk and reciprocal regulation of phosphorylation and ubiquitination mediated by receptor-like kinases and U-box E3 ligases during plant growth and environmental stress responses. [PDF]

Plant Commun
Li G, Peng Y, Sun M, Qin Z, Dai S.
europepmc   +1 more source