Results 211 to 220 of about 274,920 (356)

AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis

, 2019
Tzu-Chi Chen, Jian‐Ying Chuang, Chiung-Yuan Ko, Tzu‐Jen Kao, Pei-Yu Yang, Chun-Hui Yu, Mingsheng Liu, Siou-Lian Hu, Yu-Ting Tsai, Hardy Chan, Wen‐Chang Chang, Tsung‐I Hsu   +11 more
openalex   +1 more source

Minireview: Ubiquitination-regulated G Protein-Coupled Receptor Signaling and Trafficking [PDF]

, 2013
Verónica Alonso, Peter A. Friedman
openalex   +1 more source

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

OTUB1 stabilizes PRRSV matrix protein through a non-canonical deubiquitination mechanism to promote viral replication. [PDF]

J Virol
Liu B, Liang W, Li X, Jiang S, Shi Z, Liu N, Zhu R, Dong X, Zhou H, Zhou B, Cui J.   +10 more
europepmc   +1 more source

Celastrol suppresses mTOR signaling by altering its association with chaperones and inducing its ubiquitination in breast cancer cells

, 2018
Weiying Zhou, Xiaoli Li, Xintong Yao, Duanfang Zhou, Liangyuan Long   +4 more
openalex   +2 more sources

How could Parkin-mediated ubiquitination of mitofusin promote mitophagy? [PDF]

, 2010
Elena Ziviani, Alexander J. Whitworth
openalex   +1 more source

Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants

Advanced Science, EarlyView.
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
wiley   +1 more source

Advances in protein ubiquitination modification and immune evasion of breast cancer. [PDF]

Front Cell Dev Biol
Wu Y, Jin J, Cheng X, Fu Z, Xie H.
europepmc   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

HIV Replication in CD4+ T Lymphocytes in the Presence and Absence of Follicular Dendritic Cells: Inhibition of Replication Mediated by α-1-Antitrypsin through Altered IκBα Ubiquitination [PDF]

, 2011
Xueyuan Zhou, Leland Shapiro, Gilbert W. Fellingham, Barry M. Willardson, Gregory F. Burton   +4 more
openalex   +1 more source