Results 231 to 240 of about 187,561 (340)

Ubiquitin [PDF]

, 2018
openaire   +1 more source

Protein post-translational modifications in serine synthetic pathway: functions and molecular mechanisms. [PDF]

Cell Commun Signal
Shu M, Liu Y, Wang J.
europepmc   +1 more source

Mitigating Cell Cycle Effects in Multi‐Omics Data: Solutions and Analytical Frameworks

Advanced Science, EarlyView.
The study highlights the cell‐cycle effects on multi‐omics analysis attributed to varying cell cycle compositions across cell types. To minimize the influence, we propose RTD correction in CNV calling with a high S‐phase ratio, and phase comparison in chromatin accessibility, DNA methylation, and transcriptomics.
Rui Nie, Caihong Zheng, Likun Ren, Yue Teng, Yaoyu Sun, Lifei Wang, Junya Li, Jun Cai   +7 more
wiley   +1 more source

Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents [PDF]

, 2001
Tomomi Inoue, Rory Geyer, Zhong Yu, Carl G. Maki   +3 more
openalex   +1 more source

Tumor Small Extracellular Vesicle‐Transmitted LncRNA CATED Promotes Platinum‐Resistance in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Overcoming platinum resistance in high‐grade serous ovarian cancer (HGSOC) is critical for improving outcomes. This study identifies lncRNA CATED, elevated in platinum‐resistant small extracellular vesicles (sEVs) and tumors, which drives cisplatin resistance by enhancing DHX36 SUMOylation, boosting RAP1A translation, and activating MAPK signaling ...
Yi Liu, Hanyuan Liu, Chenchen Zhu, Yan Yang, Zhen Shen, Ge Shan, Liang Chen, Ying Zhou   +7 more
wiley   +1 more source

TRIM22 promotes glioblastoma development by ubiquitinating Bcl-2. [PDF]

Mol Cell Oncol
Zhang J, Chen Y, Wang G, Huang H, Liu Y, Huang J, Shao J, Jiao J, Cheng C.   +8 more
europepmc   +1 more source

Akt Enhances Mdm2-mediated Ubiquitination and Degradation of p53 [PDF]

, 2002
Yoko Ogawara, Shohei Kishishita, Toshiyuki Obata, Yuko Isazawa, Toshiaki Suzuki, Keiji Tanaka, Norihisa Masuyama, Yukiko Gotoh   +7 more
openalex   +1 more source

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source

E3 ubiquitin-protein ligase CBL inhibits non-small cell lung cancer progression via ubiquitination and degradation of KDR. [PDF]

Cell Div
Tu Z, Shen Y, Li H.
europepmc   +1 more source

Sperm ubiquitination in patients with dysplasia of the fibrous sheath [PDF]

, 2002
Vanesa Y. Rawe
openalex   +1 more source