Results 231 to 240 of about 308,731 (375)

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Positive feedback regulation between USP8 and Hippo/YAP axis drives triple-negative breast cancer progression. [PDF]

Cell Death Dis
Li X, Yang P, Wang T, Su P, Zhang C, Fangyu S, Yang H, Zhu J, Tan X, Zhuang T.   +9 more
europepmc   +1 more source

Highly specific intracellular ubiquitination of a small molecule [PDF]

Weicheng Li, Enrique Garcia-Rivera, Dylan C. Mitchell, Joel M. Chick, Micah Maetani, Rohit Bhadoria, John M. Knapp, Ryosuke Misu, Geoffrey M. Matthews, Ryosuke Shirasaki, Ricardo De Matos Simoes, Vasanthi S. Viswanathan, John L. Pulice, Matthew G. Rees, Jennifer A. Roth, Steven P. Gygi, Constantine S. Mitsiades, Cigall Kadoch, Stuart L. Schreiber, J.M. Ostrem   +19 more
openalex   +1 more source

Ubiquitin [PDF]

, 2020
openaire   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

MYC-driven TRIM27 upregulation promotes prostate cancer progression by enhancing CANX ubiquitination and activating PI3K/AKT signaling. [PDF]

Funct Integr Genomics
Wang Z, Ning J, Xu L, Cheng F.
europepmc   +1 more source

FBXO3-mediated DUSP9 ubiquitination reprograms MAPK signaling to eradicate tyrosine kinase inhibitor-resistant CML stem cells [PDF]

Xudong Li, Shiyu Zuo, B. Zhang, Zhenghua Huang, Rongfeng Xu, Mengjia Li, Hong Huang, Yaomei Wang, Yongping Song, Baijun Fang, Bian Zhilei, Wei Li   +11 more
openalex   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Cbl promotes MyD88 ubiquitin-mediated degradation in macrophages via phosphorylation and calcium mobilization. [PDF]

Front Immunol
Zhang Y, Wang D, Huang J, Wang Z, Zhu J, Lyu F, Jiang Z.   +6 more
europepmc   +1 more source

Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis [PDF]

, 2006
Laurence Abrami, Stephen H. Leppla, Gijs R. van den Brink   +2 more
openalex   +1 more source