Results 231 to 240 of about 278,733 (404)

METTL14‐Induced M6A Methylation Increases G6pc Biosynthesis, Hepatic Glucose Production and Metabolic Disorders in Obesity

Advanced Science, EarlyView.
It is shown that obesity is associated with increases in hepatic METTL14 and m6A methylation of G6pc transcript. YTHDF1 and YTHDF3 bind to m6A‐marked G6pc mRNA to increase its synthesis. Hepatocyte‐specific deletion of Mettl14 decreases G6pc m6A methylation, G6pc biosynthesis, and G6pc‐mediated gluconeogenesis, alleviating glucose metabolic defects in ...
Qiantao Zheng, Xiao Zhong, Qianqian Kang, Zhiguo Zhang, Decheng Ren, Yong Liu, Liangyou Rui   +6 more
wiley   +1 more source

Ubiquitin-Dependent Signaling: The Role of Ubiquitination in the Response of Cells to Their Environment.

, 1999
Keith D. Wilkinson
openalex   +1 more source

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27 ^Kip1 by ubiquitination [PDF]

, 2000
Vladimir N. Podust, James E. Brownell, Tatiana Gladysheva, Rong-Shu Luo, Chun‐Hua Wang, Michael B. Coggins, Jacqueline W. Pierce, Eric S. Lightcap, Vincent Chau   +8 more
openalex   +1 more source

Ligand binding directly stimulates ubiquitination of the inositol 1,4,5-trisphosphate receptor [PDF]

, 2000
Chang-Cheng Zhu, Richard J.H. Wojcikiewicz   +1 more
openalex   +2 more sources

Ethylene‐Activated E3 Ubiquitin Ligase MdEAEL1 Promotes Apple Fruit Softening by Facilitating the Dissociation of Transcriptional Repressor Complexes

Advanced Science, EarlyView.
Ethylene‐activated MdEAEL1 mediates the disassembly of the MdZFP3‐MdTPL4‐MdHDA19 transcriptional repression complex, upregulating the histone acetylation levels in the promoter regions of cell wall degradation‐related genes, consequently promoting softening during storage.
Tong Li, Li Liu, Guangxin Yang, Yingcong Cai, Yingda Wang, Bowen Sun, Le Sun, Weiting Liu, Aide Wang   +8 more
wiley   +1 more source

Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination [PDF]

, 2000
Olivier Staub, Hugues Abriel, Pamela Plant, Toru Ishikawa, Voula Kanelis, R. Saleki, Jean-Daniel Horisberger, Laurent Schild, Daniela Rotin   +8 more
openalex   +1 more source

PRMT1‐Mediated SWI/SNF Complex Recruitment via SMARCC1 Drives IGF2BP2 Transcription to Enhance Carboplatin Resistance in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
PRMT1 drives carboplatin resistance and tumor progression in head and neck squamous cell carcinoma (HNSCC) through a novel, methyltransferase‐independent mechanism. It recruits the SWI/SNF complex to activate IGF2BP2, promoting tumor growth and carboplatin resistance. PBX2 upregulates PRMT1, reinforcing this pathway. This study uncovers a non‐catalytic
Shixian Liu, Wentao Zhang, Weiwei Liu, Zhao Ding, Ruijing Zhang, Yuefeng Han, Zihao Niu, Mengdie Zhang, Hui Li, Dapeng Li, Zixi Wang, Jie Peng, Yu Wu, Yanxun Han, Zihui Xie, Jing Wu, Liang Qin, Zhongdong Hu, Xu Chen, Yunlong Hu, Yehai Liu, Shiyin Ma, Xiaojun Zha   +22 more
wiley   +1 more source

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

, 1997
Olivier Staub
openalex   +2 more sources

Harnessing the Ubiquitination Machinery to Target the Degradation of Specific Cellular Proteins [PDF]

, 2000
Pengbo Zhou, Robert Bogacki, Lisa J. McReynolds, Peter M. Howley   +3 more
openalex   +1 more source

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source