Results 341 to 350 of about 278,733 (404)

Insights into the potential role of BMSCs-exo delivered USP14 on SIRT1 deubiquitination in Staphylococcus aureus-induced model of osteomyelitis. [PDF]

J Orthop Surg Res
Yu J, Yang M, Jin Y, Yang K, Yang H.
europepmc   +1 more source

Chromenone derivatives as CRM1 Inhibitors for Targeting Glioblastoma

ChemBioChem, Accepted Article.
Glioblastoma (GBM) is one of the most aggressive and deadly cancers. Due to the complexity and redundancy within signaling networks in GBM, targeted inhibitors of specific pathways have shown only limited success. The nuclear export receptor Chromosome Region Maintenance 1 (CRM1) has recently emerged as a promising therapeutic target, as its inhibition
Wolfgang Link, Salvatore Princiotto, Lucía Jiménez, Lucía Domínguez, João G. N. Sequeira, Cristiana Mourato, Alba Orea-Soufi, Bruno Santos, Sabrina Dallavalle, Miguel Machuqueiro, Bibiana I. Ferreira   +10 more
wiley   +1 more source

c-Cbl Is Involved in Met Signaling in B Cells and Mediates Hepatocyte Growth Factor-Induced Receptor Ubiquitination

, 2002
Taher E.I. Taher, Esther P.M. Tjin, Esther A. Beuling, Jannie Borst, Marcel Spaargaren, Steven T. Pals   +5 more
openalex   +1 more source

Post-Translational Modifications in Multiple Myeloma: Mechanisms of Drug Resistance and Therapeutic Opportunities. [PDF]

Biomolecules
Hu S, Xu J, Cui W, Jin H, Wang X, Maimaitiyiming Y.   +5 more
europepmc   +1 more source

Advancing the Exploration of the Ubiquitin‐like Protein FUBI with Synthetic Chemical Tools

ChemBioChem, Accepted Article.
The Ubiquitin‐like protein FUBI is encoded in humans by the FAU gene, whose down‐regulation in prostate, ovarian and breast cancer is significantly associated with poor prognosis. Despite its implications in disease progression, the regulatory mechanisms orchestrated by FUBI remain elusive. To address this knowledge gap, we developed a linear synthetic
Francesca D'Amico, Cami Talavera Ormeño, Shivanganie Poeran, Jimmy Akkermans, Rayman T.N. Tjokrodirijo, Bharath Sampadi, Peter van Veelen, Aysegul Sapmaz, Monique Priscilla Catharina Mulder   +8 more
wiley   +1 more source

Chromatin-associated cullin-RING E3 ubiquitin ligases: keeping transcriptionally active NF-κB in check. [PDF]

Front Immunol
Gong M, Luo J, Liang Q, Liu Y, Zheng Y, Yang XD.   +5 more
europepmc   +1 more source

Conformational Switch in the Alpha‐Synuclein C‐Terminal Domain Directs Its Fibril Polymorphs

Chemistry – A European Journal, EarlyView.
The conformational state of the C‐terminal domain determines the fibril morphology of full‐length wild‐type alpha‐synuclein: high C‐terminus flexibility promotes twisted fibrils, while partial C‐terminal folding drives the assembly of rod‐like fibrils.
Cesar Aguirre, Yohei Miyanoiri, Masatomo So, Hajime Tamaki, Takahiro Maruno, Junko Doi, Nan Wang, Keiichi Yamaguchi, Kichitaro Nakajima, Yu Yamamori, Hiroko Inoura, Chi‐Jing Choong, Keita Kakuda, Takahiro Ajiki, Yasuyoshi Kimura, Tatsuhiko Ozono, Kousuke Baba, Seiichi Nagano, Yoshitaka Nagai, Hirotsugu Ogi, Susumu Uchiyama, Yoh Matsuki, Kentaro Tomii, Yuji Goto, Kensuke Ikenaka, Hideki Mochizuki   +25 more
wiley   +1 more source

Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment. [PDF]

Cell Death Discov
Yang X, Liu Y, Cao J, Wu C, Tang L, Bian W, Chen Y, Yu L, Wu Y, Li S, Shen Y, Xia J, Du J.   +12 more
europepmc   +1 more source

Late‐Stage Intermolecular O‐Peptidylation Protocol Enabled by Sequential Acyl Transfer on Thiol‐Incorporated Threonine Followed by Desulfurization

Chemistry – A European Journal, EarlyView.
The late‐stage intermolecular O‐acylation of the threonine (Thr) side chain was accomplished by reacting thiol‐incorporated Thr with a peptide thioester in open air. The thioester, which contained the volatile trifluoroethanethiol, facilitated the formation of S,O‐diacyl peptides.
Daiki Sato, Rika Ota, Chiho Shinozaki, Masaya Denda, Akira Otaka   +4 more
wiley   +1 more source

Transcriptomics-based exploration of ubiquitination-related biomarkers and potential molecular mechanisms in laryngeal squamous cell carcinoma. [PDF]

BMC Med Genomics
Chen Q, Wu Z, Ma Y.
europepmc   +1 more source